Article
Neurosciences
Yuan Cheng, Ruru Chen, Bowen Su, Guimin Zhang, Yutian Sun, Pengying An, Yue Fang, Yifan Zhang, Ye Shan, Etienne de Villers-Sidani, Yunfeng Wang, Xiaoming Zhou
Summary: Antidepressants can have negative effects on auditory processing, worsening psychiatric symptoms. These drugs can affect auditory memory, cortical neuron response, and perineuronal nets. Pairing drug treatment with enriched sound exposure can help alleviate these effects. These findings are important for understanding the impact of antidepressants on hearing and developing new treatment strategies for psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Michael S. Borland, Elizabeth P. Buell, Jonathan R. Riley, Alan M. Carroll, Nicole A. Moreno, Pryanka Sharma, Katelyn M. Grasse, John M. Buell, Michael P. Kilgard, Crystal T. Engineer
Summary: Pairing sound contrasts with VNS can significantly influence neural activity in the auditory pathway, leading to increased response strength and discriminability. However, pairing VNS with only one sound does not have the same effect on neural responses. Understanding the impact of different sound contrasts and neural activity patterns on plasticity could have important clinical implications for treating auditory processing disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Alexa J. Denton, Ariel Finberg, Peter E. Ashman, Nathalie B. Bencie, Tricia Scaglione, Brianna Kuzbyt, Fred F. Telischi, Rahul Mittal, Adrien A. Eshraghi
Summary: This paper discusses the application of rTMS in treating tinnitus and reviews the impact of different protocols on efficacy. Most studies show significant efficacy of rTMS in treating tinnitus, but further research is needed to support its clinical use.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Zheng Gan, Han Li, Paul Naser, Yechao Han, Linette Liqi Tan, Manfred J. Oswald, Rohini Kuner
Summary: Non-invasive, repetitive direct anodal current transcranial stimulation of the prefrontal cortex exerted long-lasting analgesic effects in mice with neuropathic pain, reversing established allodynia and affecting basal activity and responsiveness of distant areas. The study provides valuable insights into the neural mechanisms of prefrontal tDCS in neuropathic pain, highlighting the potential for non-invasive transcranial stimulation paradigms to achieve pain relief in chronic states.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Katharina S. Rufener, Christian Wienke, Alena Salanje, Aiden Haghikia, Tino Zaehle
Summary: This study investigates the effects of pairing tones with transcutaneous auricular vagus nerve stimulation (taVNS) on auditory processing. Results show that taVNS can modulate auditory processing in healthy individuals, suggesting potential applications in auditory disorders.
Review
Audiology & Speech-Language Pathology
Yvette Grootjans, Gabriel Byczynski, Sven Vanneste
Summary: This article reviews the application of non-invasive brain stimulation techniques in auditory perceptual learning. Research has found a correlation between auditory perceptual learning and synaptic plasticity mechanism, as well as the functional organization of the primary auditory cortex and frequency discrimination ability. However, the use of non-invasive brain stimulation in auditory perceptual learning still faces challenges.
Article
Neurosciences
Karita E. Ojala, Matthias Staib, Samuel Gerster, Christian C. Ruff, Dominik R. Bach
Summary: This study investigated the potential of noninvasive neural stimulation on the human sensory cortex in inhibiting aversive memory. The results showed that threat memory was attenuated in the experimental group compared with the control group after overnight consolidation. This suggests that noninvasive targeted stimulation of the sensory cortex may provide a new avenue for interfering with aversive memories in humans.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Akane Matsumura, Yohei Ishishita, Kenji Ibayashi, Yoshiyuki Onuki, Kensuke Kawai, Hirokazu Takahashi
Summary: The study found that VNS may strengthen the FF pathway through the cholinergic system and attenuate the FB pathway through the noradrenergic system in the auditory cortex. This modulation of cortical gain through VNS-induced neuromodulatory system sheds new light on the effects of VNS on auditory processing.
Article
Neurosciences
Bingmin Luo, Jing Li, Jingpeng Liu, Funi Li, Miaoqing Gu, Haoran Xiao, Shujun Lei, Zhongju Xiao
Summary: The brain regions responsible for the formation of auditory threat memory and perceptual decisions remain uncertain. This study used chemogenetic and optogenetic manipulations to investigate the roles of different brain regions in threat memory learning. The results suggest that the temporal association cortex plays a crucial role in auditory threat memory formation, with inputs from A1, A2, and MGm.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Ying Zhu, Feng Xu, Dewen Lu, Peijing Rong, Jiafei Cheng, Miaomiao Li, Yaoyao Gong, Chao Sun, Wei Wei, Lin Lin, Jiande D. Z. Chen
Summary: This study found that transcutaneous auricular vagal nerve stimulation has therapeutic potential for functional dyspepsia by improving gastric accommodation and slow waves through enhancing vagal efferent activity, leading to alleviation of dyspeptic symptoms, anxiety, and depression.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
M. Leitzke, S. Schimpf, M. Altrock, P. Schonknecht, S. Bischoff, H. Schubert, D. Hoyer, R. Bauer, S. Olbrich
Summary: Electrical stimulation of the gastric wall may shift the sympathetic-vagal balance towards parasympathetic predominance, as indicated by a decrease in sympathetic dominance marker nLF (from 58.00 to 25.52) and an increase in vagal dominance marker nHF (from 41.48 to 74.16). During gastric electrical stimulation, there was no difference in heart rate compared to baseline.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Psychiatry
Chun-Hung Chang, Wen-Lung Wang, Yu-Hui Shieh, Han-Yuan Peng, Chen-Syuan Ho, Hsin-Chi Tsai
Summary: This study reports the case of a 62-year-old male patient with treatment-refractory tinnitus and depression who significantly improved after undergoing low-frequency rTMS over the right-side dorsolateral prefrontal cortex and left auditory cortex area. The findings suggest that sequential stimulation of multiple brain regions using low-frequency rTMS may have clinical benefits for patients with tinnitus and depression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Ashley L. Garrett, Jason Burch, Yue Zhang, Haojia Li, Krishna M. Sundar, Robert J. Farney
Summary: This retrospective study compared standard AASM criteria with alternative criteria to better measure sleep-disordered breathing induced by VNS and assessed clinically relevant outcome variables and response to positive airway pressure therapy. The study found that the AASM scoring criteria significantly underestimated the degree of respiratory disturbances caused by VNS, and VNS events were not associated with increased arousals or significant hypoxemia. PAP therapy was ineffective in treating this population.
Article
Cardiac & Cardiovascular Systems
Yanqiu Lai, Xiaoya Zhou, Fuding Guo, Xiaoxing Jin, Guannan Meng, Liping Zhou, Hu Chen, Zhihao Liu, Lilei Yu, Hong Jiang
Summary: Transcutaneous vagal nerve stimulation (tVNS) plays a cardio-protective role in preventing doxorubicin (DOX)-induced cardiotoxicity by rebalancing autonomic tone and reducing cardiac damage. tVNS also regulates immune system genes involved in the underlying mechanisms.
CARDIOVASCULAR RESEARCH
(2022)
Review
Physiology
Lindsea C. Booth, Baagavi Saseetharan, Clive N. May, Song T. Yao
Summary: Patients with heart failure have varying results with vagal nerve stimulation. This review focuses on the targeting of specific cardiac-projecting vagal fibers as a potential treatment for heart failure.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Clinical Neurology
David T. Pruitt, Tanya T. Danaphongse, Megan Lutchman, Nishi Patel, Priyanka Reddy, Vanesse Wang, Anjana Parashar, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: The study found that moderate-intensity VNS paired with rehabilitation training maximizes recovery of motor function in models of ischemic stroke. VNS at 0.8 mA was beneficial for functional recovery, while VNS at 0.4 mA and 1.6 mA were not sufficient to improve recovery compared to equivalent rehabilitation without VNS.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Behavioral Sciences
Michael J. Darrow, Tabarak M. Mian, Miranda Torres, Zainab Haider, Tanya Danaphongse, Armin Seyedahmadi, Robert L. Rennaker, Seth A. Hays, Michael P. Kilgard
Summary: Combining VNS with tactile rehabilitation significantly improves the recovery of somatosensory and motor function after neurological injury. The specific components of the tactile rehabilitation paired with VNS play a crucial role in determining the degree of recovery.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Robert A. Morrison, Tanya T. Danaphongse, Stephanie T. Abe, Madison E. Stevens, Vikram Ezhil, Armin Seyedahmadi, Katherine S. Adcock, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: The study found that moderate intensity VNS can enhance motor cortex plasticity in rats, while replacing half of moderate intensity stimulation with high intensity VNS can block this enhancement, and reinstating plasticity can be achieved by removing high intensity stimulation and using only 50 pairings of moderate intensity VNS.
Article
Neurosciences
Rimenez R. Souza, Nicole M. Robertson, Christa K. McIntyre, Robert L. Rennaker, Seth A. Hays, Michael P. Kilgard
Summary: Studies in rodents show that a specific range of VNS intensities enhances extinction learning and reduces conditioned fear. The intensity of 0.8 mA VNS has shown significant effects in pairing with extinction training, suggesting it may be the optimal choice for using VNS as an adjuvant in exposure therapies for PTSD.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Robert A. Morrison, Stephanie T. Abe, Tanya Danaphongse, Vikram Ezhil, Armaan Somaney, Katherine S. Adcock, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: Vagus nerve stimulation (VNS) enhances synaptic plasticity during motor rehabilitation, and common pharmaceuticals at clinically relevant doses are unlikely to negatively impact the efficacy of VNS therapy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Katherine S. Adcock, Tanya Danaphongse, Sarah Jacob, Harshini Rallapalli, Miranda Torres, Zainab Haider, Armin Seyedahmadi, Robert A. Morrison, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: VNS therapy fails to improve somatosensory or motor function recovery in the forelimb after radial nerve injury, indicating that pain may limit the efficacy of this treatment.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Gia Valles, Jessica L. L. Huebschman, Elsbeth Chow, Corinne Kelly, Yuhong Guo, Laura N. N. Smith
Summary: Intravenous self-administration is a behavioral method used in animal models to study the reinforcing effects of drug abuse. It provides valuable insight into the neurobiological basis of addiction and the development of substance abuse disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Rimenez R. Souza, Mark B. Powers, Robert L. Rennaker, Christa K. McIntyre, Seth A. Hays, Michael P. Kilgard
Summary: Studies have shown that vagus nerve stimulation (VNS) enhances extinction learning in rodent models. Pairing VNS with the conditioned stimulus or delivering continuous stimulation throughout extinction can promote the greatest reduction in conditioned fear.
SCIENTIFIC REPORTS
(2022)
Article
Health Policy & Services
David T. Pruitt, Y. -Nhy Duong-Nguyen, Eric C. Meyers, Joseph D. Epperson, Joel M. Wright, Rachael A. Hudson, Jane G. Wigginton, Robert L. L. Rennaker, Seth A. Hays, Michael P. Kilgard
Summary: Stroke is a leading cause of chronic motor disability, but patients often face barriers in accessing optimal rehabilitative care. To address this, a system called RePlay was developed to facilitate at-home rehabilitative exercises in a gameplay environment using consumer technology. A feasibility study found that RePlay has the potential to increase engagement in rehabilitative exercises and improve overall patient outcomes.
GAMES FOR HEALTH JOURNAL
(2023)
Article
Clinical Neurology
Seth A. Hays, Robert L. Rennaker II, Michael P. Kilgard
Summary: Vagus nerve stimulation (VNS) is a bioelectronic therapy that has shown promise in stroke recovery and other domains. This study explores the underlying concepts of VNS therapy and examines the conditions that may affect its efficacy. The mechanisms of implanted VNS, stimulation parameters, pharmacological manipulations, accompanying comorbidities, and concurrent training are discussed in relation to the effectiveness of VNS therapy.
