Article
Clinical Neurology
Max Wuehr, Josefine Eder, Aram Keywan, Klaus Jahn
Summary: In patients with bilateral vestibulopathy, imperceptible noisy galvanic vestibular stimulation (nGVS) has been found to improve impaired vestibular motion perception, especially in patients with poor baseline perceptual performance. This non-invasive vestibular noise stimulation offers a potential approach to target spatial memory, orientation, and navigation impairments associated with bilateral vestibulopathy.
JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Ruth McLaren, Paul F. Smith, Rachael L. Taylor, Imran Khan Niazi, Denise Taylor
Summary: The objective of this scoping review is to summarize and report on the parameters of noisy galvanic vestibular stimulation (nGVS) that have been used to improve postural control. The study identified key nGVS parameters and evaluated their importance and influence on postural control. The results showed that various nGVS parameters, including noise waveform, amplitude, frequency band, duration of stimulation, amplitude optimization method, electrode size and composition, and electrode skin interface, have been used to augment postural control.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Max Wuehr, Josefine Eder, Silvy Kellerer, Tamara Amberger, Klaus Jahn
Summary: Previous studies have shown that treatment with low-intensity noisy galvanic vestibular stimulation (nGVS) can reduce imbalance in patients with bilateral vestibulopathy (BVP). This study aims to elucidate the potential mechanisms underlying this therapeutic effect and found that more than half of the patients showed significant improvements in postural balance compatible with stochastic resonance (SR) when treated with nGVS.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Junji Nakamura, Yohei Okada, Tomoyuki Shiozaki, Hiroaki Tanaka, Kozo Ueta, Koki Ikuno, Shu Morioka, Koji Shomoto
Summary: The vestibulospinal tract (VST) is essential for controlling antigravity muscles on the same side of the body, and the balance between the left and right VST excitability is crucial for human postural control. This study investigated the reliability and laterality of using galvanic vestibular stimulation (GVS) to increase the soleus H-reflex in healthy adults, finding no significant difference in the degree of facilitation between the left and right sides, and a moderate positive correlation with the mediolateral position of the center of pressure during standing postural control.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Max Wuehr, Eva Eilles, Magdalena Lindner, Maximilian Grosch, Roswitha Beck, Sibylle Ziegler, Andreas Zwergal
Summary: This study investigates the neurophysiological and neuroanatomical mechanisms underlying the therapeutic effects of low-intensity noisy galvanic vestibular stimulation (nGVS) on postural deficits in patients with bilateral vestibular loss (BVL). The results demonstrate that nGVS modulates regional brain activation patterns and improves posture deficits in BVL patients, particularly in the early stages of recovery. The study also reveals the link between stimulation-induced locomotor improvements and brain activity responses.
Article
Neurosciences
Max Wuehr, Florian Schmidmeier, Sabrina Katzdobler, Urban M. Fietzek, Johannes Levin, Andreas Zwergal
Summary: This study found that low-intensity noisy galvanic vestibular stimulation (nGVS) can improve postural instability in patients with advanced Parkinson's disease, and this therapeutic effect may involve stochastic resonance (SR). The beneficial effect was more pronounced in patients with more advanced disease stages and imbalance.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Chemistry, Analytical
Bulmaro A. Valdes, Kim Lajoie, Daniel S. Marigold, Carlo Menon
Summary: Noisy galvanic vestibular stimulation (nGVS) can improve motor, sensory, and cognitive behaviors, with potential cortical effects detectable through functional near-infrared spectroscopy (fNIRS) technology. In this study, subthreshold nGVS was found to elicit a greater deoxygenated hemoglobin (HbR) response in the left BA40 cortical region, suggesting fNIRS may be useful for understanding the effects of nGVS on the brain.
Article
Neurosciences
Tomoyuki Shiozaki, Yohei Okada, Junji Nakamura, Kozo Ueta, Hiroaki Tanaka, Mako Moritani, Tadashi Kitahara
Summary: We conducted a study on healthy young adults, examining the changes in LVST excitability and postural control following dynamic balance intervention. The results showed a correlation between increased LVST excitability and improved postural stability.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Audiology & Speech-Language Pathology
Martin Hitier, Yan-Feng Zhang, Go Sato, Stephane Besnard, Yiwen Zheng, Paul F. Smith
Summary: This study demonstrates the importance of vestibular information for hippocampal function and spatial memory, showing that stimulation of the same vestibular sensor can activate different specific areas in the hippocampus. The results suggest bilateral input to the hippocampus, with a high level of redundancy in the representation of vestibular information.
Article
Multidisciplinary Sciences
Kelci B. Hannan, Makina K. Todd, Nicole J. Pearson, Patrick A. Forbes, Christopher J. Dakin
Summary: The study investigates the attenuation mechanisms in decreasing vestibular gain due to noise added using supra-threshold random-waveform galvanic vestibular stimulation (GVS). Results show that first stimulus exposure caused a decrease in gain during standing, and attenuation only recommenced during walking with stimulation, suggesting two mechanisms of attenuation one associated with first stimulus exposure and another task-specific, may act to decrease vestibulomotor gain.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Po-Yin Chen, Ying-Chun Jheng, Chien-Chih Wang, Shih-En Huang, Ting-Hua Yang, Po-Cheng Hsu, Chia-Hua Kuo, Yi-Ying Lin, Wei-Yi Lai, Chung-Lan Kao
Summary: This study aimed to investigate the effects of noisy galvanic vestibular stimulation (nGVS) on healthy and bilateral vestibular hypofunction (BVH) participants in different walking conditions. The results showed that nGVS effectively reduced walking deviations for BVH patients in light conditions and decreased lateral deviation for both healthy and BVH participants in dark conditions. The C/P ratio significantly decreased for BVH participants during 2 Hz head yaw walking in light conditions.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Akiyoshi Matsugi, Koji Nagino, Tomoyuki Shiozaki, Yohei Okada, Nobuhiko Mori, Junji Nakamura, Shinya Douchi, Kosuke Oku, Kiyoshi Nagano, Yoshiki Tamaru
Summary: This study aimed to investigate the effects of noisy galvanic vestibular stimulation (nGVS) on arterial pressure (AP) and heart rate during static supine and whole-body tilting in healthy elderly individuals. The results showed that nGVS did not significantly impact MAP and RR interval variability, and there was no evidence to support the occurrence of pain, vertigo/dizziness, or discomfort with nGVS in this population.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Monica del Carmen Alvarado-Navarrete, Adriana C. Pliego-Carrillo, Claudia Ivette Ledesma-Ramirez, Carlos A. Cuellar
Summary: Understanding the interaction between neural elements in the spinal cord affected by vestibular input is important for understanding movement execution in different conditions. This study investigated the effects of Galvanic Vestibular Stimulation (GVS) on the post-activation depression (P-AD) of the H-reflex in healthy subjects. The results showed that GVS increased excitability of the vestibulospinal pathway, but did not alter the neural inhibitory mechanism present in P-AD.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Sage O. Sherman, Anna Jonsen, Quinlan Lewis, Michael Schlittenhart, Daniel Szafir, Torin K. Clark, Allison P. Anderson
Summary: This study evaluated the long-term impacts and acceptability of repeated auditory white noise and noisy galvanic vestibular stimulation on operational learning and behavioral health. The results showed that repeatedly administering sensory noise does not improve long-term operational learning performance or affect behavioral health. The use of noise stimulation in this context was found to be acceptable.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Josefine Eder, Silvy Kellerer, Tamara Amberger, Aram Keywan, Julia Dlugaiczyk, Max Wuehr, Klaus Jahn
Summary: There is no synergistic treatment effect when noisy galvanic vestibular stimulation (nGVS) is combined with vestibular rehabilitation training (VRT) in patients with bilateral vestibulopathy (BVP). However, nGVS may be used as a complementary therapeutic option during postural activities in daily life.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Katrin Rauen, Claudia B. Spaeni, Maria Carmela Tartaglia, Maria Teresa Ferretti, Lara Reichelt, Philipp Probst, Barbara Schaepers, Friedemann Mueller, Klaus Jahn, Nikolaus Plesnila
Summary: This study found that older females are more likely to be affected after TBI, reporting more moderate HRQoL outcomes. Cognitive, self-perception, and emotional issues have a negative impact on HRQoL for older females.
Article
Clinical Neurology
Roman Schniepp, Anna Huppert, Julian Decker, Fabian Schenkel, Cornelia Schlick, Atal Rasoul, Marianne Dieterich, Thomas Brandt, Klaus Jahn, Max Wuehr
Summary: The study evaluated the predictive validity of multimodal clinical assessment outcomes and quantitative measures for fall-risk estimation in patients with neurological gait disorders. Results showed that falls and fall-related injuries are a significant health issue in these patients. Fall history taking and instrument-based measures of gait and mobility are important for predicting fall status, frequency, and severity in patients at risk of falling.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
S. M. Stoecklein, M. Brandlhuber, S. S. Lause, A. Pomschar, K. Jahn, R. Schniepp, N. Alperin, B. Ertl-Wagner
Summary: This study investigates craniospinal cerebrospinal fluid (CSF) flow rates in patients with normal pressure hydrocephalus using phase-contrast MR imaging. The results show that the maximal systolic CSF flow rate is significantly decreased in patients with normal pressure hydrocephalus compared to healthy controls, suggesting a reduced compliance of the spinal CSF spaces and an ineffective spinal CSF buffer function.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Neurosciences
Roman Schniepp, Anna Huppert, Julian Decker, Fabian Schenkel, Marianne Dieterich, Thomas Brandt, Max Wuehr
Summary: This cohort study evaluated the predictive validity of clinical assessment and quantitative measures for fall-risk estimation in patients with cerebellar ataxia. The results showed that fall status and frequency could be reliably predicted, and clinical scoring and mobility measures contributed unique information for predicting fall severity.
Letter
Clinical Neurology
Aram Keywan, Gharam Yassin, Klaus Jahn, Max Wuehr
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lutz Schnabel, Max Wuehr, Anna Huppert, Stanislav Bardins, Thomas Brandt, Doreen Huppert
Summary: The visual contribution to the perceptual and postural vertical decreases with age in children, with the youngest age group showing the greatest effects and the oldest age group exhibiting the highest susceptibility to motion sickness.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Haike Dietrich, Cauchy Pradhan, Felix Heidger, Roman Schniepp, Max Wuehr
Summary: This study found that ocular-motor deficits in patients with downbeat nystagmus (DBN) were attenuated and nystagmus frequency was reduced during walking. This suggests that ocular-motor control disturbances are selectively suppressed during locomotion in DBN.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Josefine Eder, Silvy Kellerer, Tamara Amberger, Aram Keywan, Julia Dlugaiczyk, Max Wuehr, Klaus Jahn
Summary: There is no synergistic treatment effect when noisy galvanic vestibular stimulation (nGVS) is combined with vestibular rehabilitation training (VRT) in patients with bilateral vestibulopathy (BVP). However, nGVS may be used as a complementary therapeutic option during postural activities in daily life.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
M. Wuehr, J. Decker, F. Schenkel, K. Jahn, R. Schniepp
Summary: This study aimed to investigate the impact of postural and ocular-motor deficits on daily activity and risk of falling in patients with bilateral vestibular hypofunction (BVH). The results showed that patients with BVH exhibited impairments in daily activity and were at a higher risk of falling. Classificatory models based on various assessments accurately predicted the risk of falling. Therefore, measuring daily mobility can supplement standard clinical assessment and improve the identification of patients at risk of falling in BVH.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Stephanie Schmidle, Alexandra Charlotte de Crignis, Manuela Stuerzer, Joachim Hermsdoerfer, Klaus Jahn, Carmen Krewer
Summary: Posturography is an objective method to interpret postural control systematically. This study aimed to investigate the influence of different stance widths on a set of parameters in healthy older adults. Results showed that outcomes acquired in self-selected stance width provide comparable results to standardized stance widths of 20 and 30 cm.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Tina I. Tsai, Julia Dlugaiczyk, Stanislav Bardins, Doreen Huppert, Thomas Brandt, Max Wuehr
Summary: Healthy humans exhibit different combinations of nonpathological, synkinetic gaze-associated movements with aural, facial, and/or masticatory muscles during different types of voluntary and reflexive horizontal eye movements. The manifestations of these collective phenomena are strongest during large-scale horizontal saccades and accompanied by a detectable horizontal chin movement. Auricular muscle activations occur equally on both sides, whereas the activation of facial and masticatory muscles is predominantly ipsilateral (in regard to gaze direction).
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Max Wuehr, Florian Schmidmeier, Sabrina Katzdobler, Urban M. Fietzek, Johannes Levin, Andreas Zwergal
Summary: This study found that low-intensity noisy galvanic vestibular stimulation (nGVS) can improve postural instability in patients with advanced Parkinson's disease, and this therapeutic effect may involve stochastic resonance (SR). The beneficial effect was more pronounced in patients with more advanced disease stages and imbalance.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Rehabilitation
Jeannine Bergmann, Carmen Krewer, Friedemann Mueller, Klaus Jahn
Summary: The German version of SRP demonstrates excellent reliability and validity in patients with neurological disorders, providing a useful tool for assessing retropulsion. The SRP showed a wide range of scores and good correlations with other clinical balance scales.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Engineering, Biomedical
Chiara Hoehler, Emilio Trigili, Davide Astarita, Joachim Hermsdoerfer, Klaus Jahn, Carmen Krewer
Summary: Hybrid neuroprostheses, including robots and electrical stimulation, have shown positive effects on upper limb recovery after stroke, with long-lasting benefits. Among the 32 identified hybrid systems, the majority are exoskeleton devices that actively reinforce movement. The combination of Functional Electrical Stimulation and robotic components can target different levels of impairment and improve upper limb function.
