Article
Psychiatry
Lennart Christopher Schiwy, Caroline Garcia Forlim, Djo Juliette Fischer, Simone Kuehn, Maxi Becker, Juergen Gallinat
Summary: Cognitive deficits in schizophrenia and schizoaffective disorder are associated with aberrant functional connectivity in the default mode network (DMN) and salience network (SN). This study found that dysfunctional connectivity within the SN is important for cognitive deficits in psychosis, while connectivity in the DMN remains unchanged.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Fengqiong Yu, Huihua Fang, Junfeng Zhang, Zhihao Wang, Hui Ai, Veronica P. Y. Kwok, Ya Fang, Yaru Guo, Xin Wang, Chunyan Zhu, Yuejia Luo, Pengfei Xu, Kai Wang
Summary: This study shows that brain functional connectivity, especially the connectivity of the salience network (SN), frontoparietal network (FPN), and default mode network (DMN), can specifically predict individualized consummatory anhedonia in MDD. These findings suggest the potential of functional connectomes for the diagnosis and prognosis of anhedonia in MDD and other disorders.
DEPRESSION AND ANXIETY
(2022)
Article
Psychology, Clinical
Fengmei Fan, Shuping Tan, Junchao Huang, Song Chen, Hongzhen Fan, Zhiren Wang, Chiang-Shan R. Li, Yunlong Tan
Summary: This study found that patients with schizophrenia exhibit deficits in functional connectivity within the default mode network subsystems. These deficits are present in both early-stage and recurrent patients, suggesting that they may be trait-like characteristics. The findings suggest that these connectivity deficits may be useful for early diagnosis, and that dysfunction in the medial temporal lobe may play a crucial role in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Bo Zhou, Xuejiao Dou, Wei Wang, Hongxiang Yao, Feng Feng, Pan Wang, Zhengyi Yang, Ningyu An, Bing Liu, Xi Zhang, Yong Liu
Summary: This study found abnormalities in the connectivity of the default mode network in patients with aMCI and AD, and these abnormalities were correlated with the cognitive abilities of the patients. There was also structural-functional decoupling between certain components of the network.
Article
Clinical Neurology
Thamires Naela Cardoso Magalhaes, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Silva, Brunno Machado de Campos, Thiago Junqueira Ribeiro de Rezende, Liara Rizzi, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthazar
Summary: This study found that structural connectivity alterations, but not functional connectivity changes, may differentiate individuals with amnestic mild cognitive impairment with altered amyloid who will evolve to Alzheimer's disease dementia.
Article
Neurosciences
Matthew A. Cormie, Batu Kaya, Georgia E. Hadjis, Pedram Mouseli, Massieh Moayedi
Summary: The insula and the cingulate are key brain regions involved in processing affective, cognitive, and interoceptive stimuli. Using ultra-high field 7T diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), this study investigated the structural connectivity (SC) and functional connectivity (FC) between insula and cingulate subregions. The findings suggest strong connections between posterior INS and posterior MCC, and a potential mediating structure between the anterior insula and anterior mid-cingulate cortex.
Article
Psychology, Clinical
Andrea Wiglesworth, Conner A. Falke, Mark Fiecas, Monica Luciana, Kathryn R. Cullen, Bonnie Klimes-Dougan
Summary: This study explores the neural correlates of suicide ideation in children and identifies aberrant functioning in the default mode network (DMN) as a potential mechanism. These findings have important implications for suicide prevention efforts.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Ji-Yoon Lee, Chi-Hyun Choi, Minkyung Park, Sunyoung Park, Jung-Seok Choi
Summary: The study compared EEG source functional connectivity between patients with IGD and healthy controls, finding hyper-connectivities within the DMN and RSN in IGD patients. Additionally, a negative correlation was observed between the severity of IGD symptoms and gaming time with EEG source connectivity.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Adriana K. Cushnie, Wei Tang, Sarah R. Heilbronner
Summary: Human neuroimaging has revealed large-scale functional networks in the cerebral cortex consisting of functionally correlated brain regions. The salience network (SN) plays a crucial role in addiction and is disrupted in individuals with addiction. Although there is growing evidence on the SN and addiction, there are still unknowns and limitations in human neuroimaging studies. Translating human functional networks to nonhuman animals provides opportunities to investigate circuit-level mechanisms and the perturbation of the SN sheds light on functional cortical networks and addiction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Kim, Xi Zhu, Yiming A. Zhao, Sophie R. Bell, Philip Gehrman, Daniel Cohen, D. P. E. Devanand, Terry Goldberg, Seonjoo Lee
Summary: There is an interaction between sleep disturbance and Aβ burden in the altered resting state functional connectivity (rsFC) in older adults. Sleep disturbance is associated with hyperconnectivity in the Salience Network (SN) only in the presence of Aβ burden. Identifying and treating sleep problems in individuals with AD pathology may help prevent further disease progression.
MOLECULAR PSYCHIATRY
(2023)
Article
Neuroimaging
Yuqun Zhang, Yuan Yang, Xiaomin Xu, Yonggui Yuan
Summary: Research has shown a correlation between asthma and neural activity in brain circuits, particularly in the salience network (SN). Asthmatic patients display altered connections within the SN and increased connectivity with other brain regions such as the default mode network (DMN) and executive control network (ECN). Furthermore, neural activity in asthmatic patients may be associated with depressive symptoms, indicating a potential link between asthma, brain function, and mental health.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Psychiatry
Nooshin Javaheripour, Meng Li, Tara Chand, Axel Krug, Tilo Kircher, Udo Dannlowski, Igor Nenadic, J. Paul Hamilton, Matthew D. Sacchet, Ian H. Gotlib, Henrik Walter, Thomas Frodl, Simone Grimm, Ben J. Harrison, Christian Robert Wolf, Sebastian Olbrich, Guido van Wingen, Lukas Pezawas, Gordon Parker, Matthew P. Hyett, Philipp G. Saemann, Tim Hahn, Olaf Steinstraeter, Andreas Jansen, Dilara Yuksel, Robin Kaempe, Christopher G. Davey, Bernhard Meyer, Lucie Bartova, Ilona Croy, Martin Walter, Gerd Wagner
Summary: This study investigated functional alterations in MDD patients, finding significant hypoconnectivity within SMN and SN networks, as well as between various networks. Differences in network organization were observed, with MDD patients showing lower network segregation in SMN. Although medicated patients had lower FC within certain networks, network organization differences were not significant between medicated and unmedicated groups, suggesting that network organization of cortical networks may be a more stable neuroimaging marker for MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Mingqia Wang, Xiaoyu Chen, Yiru Hu, Yangling Zhou, Chengyu Wang, Wei Zheng, Weijian Liu, Xiaofeng Lan, Yuping Ning, Bin Zhang
Summary: This study explored changes in resting-state functional connectivity of the Hb in responders and nonresponders diagnosed with unipolar or bipolar depression before and after ketamine treatment. Results suggest that ketamine may exert its antidepressant efficacy through downregulation of aberrant habenular functional connectivity with parts of the default mode network.
DEPRESSION AND ANXIETY
(2022)
Article
Neurosciences
Xiaomei Li, Haitao Chen, Yannan Hu, Ryan J. Larsen, Bradley P. Sutton, Nancy L. McElwain, Wei Gao
Summary: Early functioning of neural networks is likely important for flexible switching in social interactions. The association between infants' neural networks at 3 months and their ability to engage in social interactions at 6 months was examined. Results showed that neural connectivity at 3 months predicted greater dyadic flexibility at 6 months.
Article
Clinical Neurology
Florian Holub, Roxana Petri, Julian Schiel, Bernd Feige, Martin K. Rutter, Sandra Tamm, Dieter Riemann, Simon D. Kyle, Kai Spiegelhalder
Summary: This study investigates the associations between insomnia symptoms and resting-state functional connectivity at the whole-brain level using a large sample size. The results suggest that frequent insomnia symptoms are associated with altered functional connectivity between brain networks, which may contribute to dysfunctional affective and cognitive processing and impaired sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Clinical
Debo Dong, Dezhong Yao, Yulin Wang, Seok-Jun Hong, Sarah Genon, Fei Xin, Kyesam Jung, Hui He, Xuebin Chang, Mingjun Duan, Boris C. Bernhardt, Daniel S. Margulies, Jorge Sepulcre, Simon B. Eickhoff, Cheng Luo
Summary: This study investigated the pathological interaction of sensory and cognitive function in schizophrenia and its relationship to system-level imbalance. The results revealed a compression of the cortical hierarchy organization, leading to a diminished separation between sensory and cognitive systems. Furthermore, the analysis showed reduced connectivity within unimodal regions and increased connectivity between unimodal regions and other areas. These findings suggest that disruptions in the somatosensory-motor system and inefficient integration of sensory information contribute to high-level cognitive deficits in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Yun Qin, Sipei Li, Dezhong Yao, Cheng Luo
Summary: In this study, abnormal connections in the subcortical-cortical pathway in IGE were examined using resting-state fMRI data, with a focus on the dynamics and causal relationship among these interactions. Key regions representing abnormal functional network connectivity in this circuit were identified as the thalamus and precuneus. The results also indicated a causal effect of the connectivity between the precuneus and adjacent regions on the dysfunction of the thalamocortical circuit, while the connection between the striatum and thalamus played a modulatory role in epilepsy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Wei Li, Yuchao Jiang, Yingjie Qin, Xiuli Li, Du Lei, Heng Zhang, Ding Lei, Dezhong Yao, Cheng Luo, Qiyong Gong, Dong Zhou, Dongmei An
Summary: This study explored the resting state networks (RSNs) alterations in patients with unilateral mesial temporal lobe epilepsy (mTLE) before and after surgery. The results showed that before surgery, there was decreased functional connectivity in the visual network and basal ganglia network, while after surgery, the basal ganglia network further decreased but the sensorimotor network and dorsal attention network increased. Successful surgery may lead to RSNs reorganization.
Article
Neurosciences
Yuchao Jiang, Wei Li, Yingjie Qin, Le Zhang, Xin Tong, Fenglai Xiao, Sisi Jiang, Yunfang Li, Qiyong Gong, Dong Zhou, Dongmei An, Dezhong Yao, Cheng Luo
Summary: This study used T1-weighted and T2-weighted MRI to investigate the myelination changes in temporal lobe epilepsy (TLE) patients. The mSCN analysis showed decreased myelination in frontotemporal regions, amygdala, and thalamus in both patient groups compared to healthy controls. Left TLE patients also had lower myelination in left medial temporal regions. The findings suggest that myelination alterations in TLE are related to epileptic seizures.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Changyue Hou, Sisi Jiang, Mei Liu, Hechun Li, Lang Zhang, Mingjun Duan, Gang Yao, Hui He, Dezhong Yao, Cheng Luo
Summary: This study investigates the spatiotemporal dynamics of schizophrenia and its relationship with psychiatric symptoms. A total of 98 patients with schizophrenia underwent resting-state functional magnetic resonance imaging, and the variations in functional connectivity density were evaluated. The findings show that patients exhibit altered temporal and spatial variations in different brain networks, and the variations in perceptual and attentional systems are associated with symptom severity. Moreover, the differences between patients and healthy subjects are related to the densities of dopamine, serotonin and mu-opioid receptors, as well as the densities of serotonin reuptake transporter, dopamine transporter, and dopamine synthesis capacity. Overall, this study highlights the importance of brain dynamics in understanding the pathological mechanism of schizophrenia.
Article
Neurosciences
Yun Qin, Sisi Jiang, Siwei Xiong, Sipei Li, Qiankun Fu, Lili Yang, Peishan Du, Cheng Luo, Dezhong Yao
Summary: In this study, the features of theta oscillations and the functional interactions among activation/deactivation networks during the n-back working memory (WM) task were examined in patients with idiopathic generalized epilepsy (IGE) using simultaneous EEG-fMRI. The results showed enhanced frontal theta power and increased activations in high-load WM tasks in IGE patients, as well as decreased counteraction between the activation network and deactivation network. These findings suggest the important role of the interactions between activation and deactivation networks in WM processing and provide insights into the pathophysiological mechanism of cognitive dysfunction in generalized epilepsy.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Psychology, Clinical
Narges Naghibi, Nadia Jahangiri, Reza Khosrowabadi, Claudia R. R. Eickhoff, Simon B. B. Eickhoff, Jennifer T. T. Coull, Masoud Tahmasian
Summary: Time is a pervasive element in our internal and external experiences. Despite decades of research, there is still no unified understanding of the neural substrates of time. This study conducted a meta-analysis of neuroimaging papers to explore the activation patterns related to duration processing.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Neurosciences
Xi Chen, Zian Wang, Hao Jiang, Yu Meng, Hongmei Wang, You Li, Kaijun Xu, Jiazhong Yang, Cheng Luo
Summary: This study is the first to use MRI before and after intensive flight training to investigate the effectiveness of flight training in civil flying cadets. The results showed that flight training enhanced the degree centrality values of the prefrontal and occipital cortices, which may be related to cognitive function.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Mortaza Afshani, Ahmad Mahmoudi-Aznaveh, Khadijeh Noori, Masoumeh Rostampour, Mojtaba Zarei, Kai Spiegelhalder, Habibolah Khazaie, Masoud Tahmasian
Summary: Insomnia disorder (ID) is a prevalent mental illness with various subtypes. This study found that multimodal whole-brain neuroimaging measurements can better discriminate different subtypes of ID from each other and healthy subjects compared to unimodal approaches. These preliminary findings provide evidence for further research on the mechanism of each subtype and personalized treatments for ID in the future.
Article
Medicine, General & Internal
Sisi Jiang, Huan Huang, Jingyu Zhou, Hechun Li, Mingjun Duan, Dezhong Yao, Cheng Luo
Summary: This study aimed to explore the progressive trajectories of patterns of dysfunction after diagnosis in patients with schizophrenia. Five stage-specific phenotypes were identified, and dysfunctions shifted from primary and subcortical regions to higher-order cortices. Genetic factors related to neurodevelopmental and neurodegenerative processes were found to be relevant to schizophrenia progression, suggesting potential targets for interventions.
Review
Clinical Neurology
Debora Meneo, Fateme Samea, Masoud Tahmasian, Chiara Baglioni
Summary: Theoretical models of insomnia disorder recognise the importance of emotional factors in its maintenance. Impaired sleep quality is closely associated with difficulties in regulating emotions, reduced positive affect, and increased negative affect. While there is little evidence for a bi-directional association between affective states and sleep, initial research suggests that high variability in positive affect has a negative impact on sleep. Further investigation is needed on the affective experience of insomnia disorder patients, with a focus on multiple sampling of affect throughout the day and week. Understanding the interplay between emotional processes and sleep alterations may improve tailored treatments for insomnia disorder.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Yuling Luo, Debo Dong, Huan Huang, Jingyu Zhou, Xiaojun Zuo, Jian Hu, Hui He, Sisi Jiang, Mingjun Duan, Dezhong Yao, Cheng Luo
Summary: This study proposes a research framework that combines multimodal meta-analysis and genetic/molecular architecture to solve the consistency in neuroimaging biomarkers of schizophrenia and their link to molecular genetics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Jungwoo Kang, Rita Bertani, Kausar Raheel, Matthew Soteriou, Jan Rosenzweig, Antonio Valentin, Peter J. Goadsby, Masoud Tahmasian, Rosalyn Moran, Katarina Ilic, Adam Ockelford, Ivana Rosenzweig
Summary: In this study, the presence and nature of visuo-spatial impressions in dreams of congenitally blind individuals were investigated. It was found that congenitally blind people had a higher presence of auditory, haptic, olfactory, and gustatory sensation in their dreams compared to sighted individuals. Interestingly, some congenitally blind subjects also reported oneiric visual imagery, contradicting previous studies and raising questions about the underlying neuro-mechanisms.
Article
Clinical Neurology
Haonan Pei, Shuai Ma, Wei Yan, Zetao Liu, Yuehan Wang, Zhihuan Yang, Qifu Li, Dezhong Yao, Sisi Jiang, Cheng Luo, Liang Yu
Summary: This study found that untreated patients with generalized tonic-clonic seizures have disturbances in large-scale network structure and function, which are alleviated by antiseizure medication. The effects of medication are more noticeable in the functional network, while structural alterations exist both before and after treatment.
Article
Clinical Neurology
Julian E. Schiel, Sandra Tamm, Florian Holub, Roxana Petri, Hassan S. Dashti, Katharina Domschke, Bernd Feige, Matthew O. Goodman, Samuel E. Jones, Jacqueline M. Lane, Pietro-Luca Ratti, David W. Ray, Susan Redline, Dieter Riemann, Martin K. Rutter, Richa Saxena, Claire E. Sexton, Masoud Tahmasian, Heming Wang, Michael N. Weedon, Antoine Weihs, Simon D. Kyle, Kai Spiegelhalder
Summary: Investigating associations between sleep health and grey matter volume in over 33,000 individuals, the study found that insomnia symptoms do not directly affect brain morphometry. Long sleep duration was associated with larger grey matter volume of basal ganglia substructures, possibly indicating early stage sleep apnoea in old age. The importance of sleep health in future morbidity and mortality is highlighted.
BRAIN COMMUNICATIONS
(2023)