Article
Oncology
Xiaojun Ren, Yingli Fu, Zhongshan Liu, Xia Lin, Ling Qiu, Yunfeng Li, Hanyang Li, Yuqi Bai, Tiejun Wang
Summary: This study evaluated the efficacy and toxicity of image-guided high-dose rate (HDR) interstitial brachytherapy (ISBT) for the reirradiation of cervical cancer within a previously irradiated area. The results showed a complete response rate of 56.5% after reirradiation, with decreasing post-relapse survival rates over time. Urinary and rectal toxicity were significant, but manageable. Tumor volume, treatment-free interval, tumor invasion organ number, and local control were important prognostic factors for overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jun Itami, Naoya Murakami, Miho Watanabe, Shuhei Sekii, Takahiro Kasamatsu, Shingo Kato, Hisako Hirowatari, Hitoshi Ikushima, Ken Ando, Tatsuya Ohno, Hiroyuki Okamoto, Kae Okuma, Hiroshi Igaki
Summary: Three-dimensional image-guided brachytherapy has shown significant progress in the treatment of cervical cancer, as the traditional Manchester method cannot deliver an adequate dose. Hybrid brachytherapy, which combines interstitial and intracavitary techniques, has been proven to improve local control rates and can be performed safely and effectively.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Alina Emiliana Sturdza, Johannes Knoth
Summary: Image-guided brachytherapy is an effective method for treating locally advanced cervical cancer, allowing for precise targeting and minimal harm to organs at risk.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Health Care Sciences & Services
Angel Becerra-Bolanos, Miriam Jimenez-Gil, Mario Federico, Yurena Dominguez-Diaz, Lucia Valencia, Aurelio Rodriguez-Perez
Summary: High-dose-rate brachytherapy (HDR) is commonly used for locally advanced uterine cervical cancer, but pain during the procedure remains a concern. In this retrospective study, data from 172 patients were analyzed to evaluate pain incidence and intensity during HDR. The results showed that 18.2% of patients experienced moderate pain, and 43.3% required analgesic rescue. Patients receiving major opioids reported worse pain control. The number of needles inserted did not affect postoperative pain assessment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Derek Liu, Shayantonee Tupor, Jaskaran Singh, Trey Chernoff, Nelson Leong, Evgeny Sadikov, Asim Amjad, Sandra Zilles
Summary: In this study, a deep learning model was developed for automated catheter reconstruction and its performance was investigated. The model achieved promising results on a large clinical dataset but faced challenges such as ultrasound artifacts and image degradation.
Review
Oncology
Aiping Wen, Xianliang Wang, Bingjie Wang, Chuanjun Yan, Jingyue Luo, Pei Wang, Jie Li
Summary: High-dose-rate brachytherapy is an essential treatment for cervical cancer. Comparisons between 60Co and 192Ir sources for HDR BT have shown that 60Co can be a feasible alternative to 192Ir, with the treatment being safe and effective.
Article
Oncology
Leonel Varela Cagetti, Laurence Gonzague-Casabianca, Christophe Zemmour, Eric Lambaudie, Gilles Houvenaeghel, Magalie Provansal, Renaud Sabatier, Laura Sabiani, Guillaume Blache, Camille Jauffret, Marjorie Ferre, Hugues Mailleux, Maria Paciencia, Agnes Tallet
Summary: The study analyzed the clinical outcomes and safety of preoperative HDR IGABT followed by MIS in early-stage cervical cancer patients, showing high local control and reduced rates of lymph-vascular space invasion.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Asma Sarwar, Narinder Lalli, Gemma Eminowicz
Summary: This study retrospectively analyzed patients with cervical cancer who underwent MRI-guided brachytherapy and interstitial needle treatment. It found that radiation dose to the ureters can cause toxicity. Re-optimization of treatment plans effectively reduced ureter dose and decreased dose to other organs in patients planned with MRI.
Article
Oncology
Umesh Mahantshetty, Lavanya Gurram, Sabheen Bushra, Yogesh Ghadi, Dheera Aravindakshan, John Paul, Vinod Hande, Avinash Pilar, Supriya Chopra, Jaya Ghosh, T. S. Shylasree, Palak Popat, Nilesh Sable, Amita Maheswari, Sudeep Gupta
Summary: The study evaluated the feasibility and safety of SA-MF, HDR IGABT for cervical cancer. The results showed promising dosimetric parameters and clinical outcomes in 95% of patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biology
Hitoshi Maemoto, Takuto Ogura, Takafumi Toita, Takuro Ariga, Seiji Hashimoto, Yuka Kawakami, Kazuki Ishikawa, Shota Takehara, Joichi Heianna, Wataru Kudaka, Yoichi Aoki, Akihiro Nishie
Summary: In CT-based image-guided brachytherapy for cervical cancer, pretreatment oral administration of a small dose of gastrografin achieved moderate efficacy for enhancing and contouring the small intestine close to the uterus/adnexa.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Oncology
Haruka Uezono, Kayoko Tsujino, Yuko Inoue, Akifumi Kajihara, Mitsuru Marudai, Ryosuke Bessho, Shuhei Sekii, Hikaru Kubota, Satoshi Yamaguchi, Yosuke Ota
Summary: This study retrospectively analyzed the optimal primary tumor dose for cervical cancer treatment using computed tomography-based image-guided brachytherapy. The results showed that HR CTV D90% ≥75 Gy was significantly associated with favorable local control.
Article
Oncology
Primoz Petric, Jacob C. Lindegaard, Alina Sturdza, Lars Fokdal, Kathrin Kirchheiner, Li T. Tan, Maximilian P. Schmid, Christine Haie-Meder, Ina M. Juergenliemk-Schulz, Erik van Limbergen, Peter Hoskin, Charles Gillham, Ekkasit Tharavichitkul, Umesh Mahantshetty, Elena Villafranca, Kari Tanderup, Christian Kirisits, Richard Poetter
Summary: This study demonstrates that chemoradiation with IGBT for stage IB cervical cancer leads to excellent loco-regional control with limited morbidity, making it a good alternative to surgery in some cases.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Reza Mohammadi, Iman Shokatian, Mohammad Salehi, Hossein Arabi, Isaac Shiri, Habib Zaidi
Summary: This study proposed a method for automatic contouring of organs at risk in high-dose rate brachytherapy using a deep convolutional neural network. By analyzing images of 113 patients with cervical cancer, the method demonstrated excellent accuracy and consistency in segmenting the bladder, rectum, and sigmoid.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahdieh Dayyani, Elie Hoseinian-Azghadi, Hashem Miri-Hakimabad, Laleh Rafat-Motavalli, Sara Abdollahi, Najmeh Mohammadi
Summary: This study aimed to compare the biological effective doses (BEDs) to clinical target volume (CTV) and organs at risk (OARs) for cervical cancer patients treated with high-dose-rate (HDR) Iridium-192 (Ir-192) or Cobalt-60 (Co-60) brachytherapy (BT) boost and found that RBE values are the most important cause of discrepancies between the two sources. The study suggests that a dose escalation to similar to 4% is feasible and safe, but further clinical validation is needed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohammad Salehi, Alireza Vafaei Sadr, Seied Rabi Mahdavi, Hossein Arabi, Isaac Shiri, Reza Reiazi
Summary: This study proposes a simulation framework considering organ deformation for locally advanced cervical cancer. The framework uses deep learning-based non-rigid image registration, which outperforms conventional algorithms.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Biology
Naoya Murakami, Ikumi Kuno, Hiroshi Yoshida, Kouya Shiraishi, Tomoyasu Kato, Hiroshi Igaki
Summary: The study suggested the possibility of de-escalation for cervical cancer, similar to HPV-related oropharyngeal cancer. However, the classification was based on tumor shrinkage after half of the treatment, while another article found adverse factors that could be obtained prior to treatment, allowing for earlier patient classification.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Oncology
Naoya Murakami, Kae Okuma, Hiroyuki Okamoto, Satoshi Nakamura, Tairo Kashihara, Tomoya Kaneda, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Koji Masui, Ken Yoshida, Tomoyasu Kato, Jun Itami
Summary: This study investigated the efficacy and side effects of salvage re-irradiation using image-guided high-dose-rate brachytherapy (IG-HDR-BT) in patients with gynecologic malignancies who had a history of pelvic irradiation. The results showed that re-irradiation with IG-HDR-BT could be considered in patients with recurrent disease, especially those with small tumor size and no history of bevacizumab usage.
JOURNAL OF CONTEMPORARY BRACHYTHERAPY
(2022)
Review
Oncology
Jun Itami, Naoya Murakami, Miho Watanabe, Shuhei Sekii, Takahiro Kasamatsu, Shingo Kato, Hisako Hirowatari, Hitoshi Ikushima, Ken Ando, Tatsuya Ohno, Hiroyuki Okamoto, Kae Okuma, Hiroshi Igaki
Summary: Three-dimensional image-guided brachytherapy has shown significant progress in the treatment of cervical cancer, as the traditional Manchester method cannot deliver an adequate dose. Hybrid brachytherapy, which combines interstitial and intracavitary techniques, has been proven to improve local control rates and can be performed safely and effectively.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Akihiro Ishiguro, Dai Ogata, Kae Okuma, Tairo Kashihara, Naoya Murakami, Kojiro Hiki, Kohei Yamakawa, Shunichi Jinnai, Akira Takahashi, Kenjiro Namikawa, Hiroshi Igaki, Naoya Yamazaki
Summary: This study summarizes the demographic and clinical characteristics of patients with malignant melanoma who received brachytherapy. Brachytherapy showed good effectiveness in local control and palliative care, especially in the treatment of vaginal lesions. However, it was not very effective for lymph node metastases.
JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Naoya Murakami, Ami Takano, Itsumi Niizeki, Madoka Sakuramachi, Tairo Kashihara, Hiroyuki Okamoto, Mikiko Ito, Takao Ueno, Hiroshi Igaki
Summary: This article aims to provide a comprehensive guide on nursing care for head and neck interstitial brachytherapy (ISBT) to radiation oncologists and nurses, in order to promote the widespread use of this treatment strategy. Nurses caring for patients with head and neck cancer undergoing ISBT should have a thorough understanding of radiation therapy principles, technology, applicator management, and the acute and chronic side effects of ISBT.
Article
Oncology
Naoya Murakami, Miho Watanabe, Takashi Uno, Shuhei Sekii, Kayoko Tsujino, Takahiro Kasamatsu, Yumiko Machitori, Tomomi Aoshika, Shingo Kato, Hisako Hirowatari, Yuko Kaneyasu, Tomio Nakagawa, Hitoshi Ikushima, Ken Ando, Masumi Murata, Ken Yoshida, Hiroto Yoshioka, Kazutoshi Murata, Tatsuya Ohno, Noriyuki Okonogi, Anneyuko I. Saito, Mayumi Ichikawa, Takahito Okuda, Keisuke Tsuchida, Hideyuki Sakurai, Ryoichi Yoshimura, Yasuo Yoshioka, Atsunori Yorozu, Naonobu Kunitake, Hiroyuki Okamoto, Koji Inaba, Tomoyasu Kato, Hiroshi Igaki, Jun Itami
Summary: The objective of this study was to demonstrate the feasibility and effectiveness of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced cervical cancer patients. The results showed that HBT was effective and there is room for improvement.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Rei Umezawa, Hideki Tokunaga, Takaya Yamamoto, Shogo Shigeta, Noriyoshi Takahashi, Kazuya Takeda, Yu Suzuki, Keita Kishida, Kengo Ito, Noriyuki Kadoya, Muneaki Shimada, Keiichi Jingu
Summary: This study retrospectively analyzed patients with LACC treated with ICBT/ISBT, showing 3-year rates of 88.2% for LC, 56.6% for PFS, and 65.4% for OS. Corpus invasion and large HR-CTV were significant prognostic factors for LC, PFS, and OS, with late toxicities detected in 6.8% of patients.
Article
Biology
Naoya Murakami, Fumihiko Nakatani, Kana Takahashi, Satoshi Nakamura, Hiroshi Igaki, Naoto Shikama
Summary: An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal. Preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was initially offered but deemed impossible. Amputation was suggested but refused by the patient. Salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was performed, resulting in no local progression or distant metastasis after 2 years.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Biology
Ayaka Nagao, Hiroyuki Okamoto, Hiroki Nakayama, Takahito Chiba, Daisuke Fujiyama, Junichi Kuwahara, Tatsuya Sakasai, Tairo Kashihara, Tomoya Kaneda, Koji Inaba, Kae Okuma, Naoya Murakami, Hiroshi Igaki
Summary: This study evaluated the movement of the uterus during radiotherapy and its effects on surrounding organs. The uterus showed greater movement than the cervix and was more correlated with the bladder than the rectum. Individualized optimal margins are needed to ensure sufficient dose coverage of the clinical target volume.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Rei Umezawa, Masamichi Mizuma, Kei Nakagawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Michiaki Unno, Keiichi Jingu
Summary: This study aimed to investigate the treatment outcomes of chemoradiotherapy using S-1 after gemcitabine plus nab-paclitaxel for borderline resectable and unresectable locally advanced pancreatic cancer. The results showed that patients who underwent conversion surgery after CRT had longer overall survival, and the duration of postoperative chemotherapy affected the overall survival.
Article
Oncology
Kengo Hiranuma, Yuka Asami, Mayumi Kobayashi Kato, Naoya Murakami, Yoko Shimada, Maiko Matsuda, Shu Yazaki, Erisa Fujii, Kazuki Sudo, Ikumi Kuno, Masaaki Komatsu, Ryuji Hamamoto, Hideki Makinoshima, Koji Matsumoto, Mitsuya Ishikawa, Takashi Kohno, Yasuhisa Terao, Atsuo Itakura, Hiroshi Yoshida, Kouya Shiraishi, Tomoyasu Kato
Summary: This study determined the distribution of FGFR fusion genes in cervical cancer patients using RNA-based analysis, and classified patients into clinically relevant subgroups. The results showed a higher frequency of FGFR fusion genes in cervical cancer compared to other cancers, and different gene expression patterns were associated with prognosis.
Article
Oncology
Naoya Murakami, Kanako Kojima, Kae Okuma, Tairo Kashihara, Satoshi Nakamura, Wakako Shimizu, Ryuichiro Suda, Hiroshi Igaki, Naoto Shikama
Summary: This technical report discusses the use of high-dose-rate intracavitary brachytherapy boost using a vaginal shielded cylindrical applicator combined with pelvic external beam radiation therapy for T3 rectal cancer patients. It has been shown that a group of rectal cancer patients will achieve a pathological complete response following preoperative chemoradiotherapy, and non-operative management has recently gained attention. To escalate the tumour dose and increase the likelihood of pathological complete response, brachytherapy can play an important role in safely increasing the total dose. However, at the time this report was published, an applicator dedicated to rectal brachytherapy was unaffordable in Japan. Here, we report two T3 rectal cancer patients who were inoperable or refused surgery and treated by chemoradiotherapy following intracavitary brachytherapy involving a vaginal cylinder applicator with lead shielding.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Naoya Murakami, Koji Masui, Ken Yoshida, Shin-ei Noda, Miho Watanabe, Tadashi Takenaka, Noriko Ii, Kazushige Atsumi, Rei Umezawa, Koji Inaba, Kotaro Iijima, Akiko Kubo, Hiroshi Igaki, Naoto Shikama, Hitoshi Ikushima
Summary: This article discusses a hands-on seminar supported by JASTRO that aimed to accelerate the implementation speed of intracavitary and interstitial brachytherapy for cervical cancer and improve the confidence level of participants.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Naoya Murakami, Kae Okuma, Ayaka Takahashi, Tomoyasu Kato, Hiroshi Igaki
Summary: Compared with guidelines from Europe and the United States, the Japanese guidelines for uterine cervical cancer management do not recommend delivering a high dose to the CTVHR D-90. While the rate of late radiation-induced toxicities is lower, the local control rate is inferior. This report aims to discuss the possibility of modifying treatment guidelines for patients with poor response.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Naoya Murakami, Madoka Sakuramachi, Tairo Kashihara, Takahito Chiba, Satoshi Nakamura, Keisuke Ono, Takao Ueno, Seiichi Yoshimoto, Ken Yoshida, Koji Masui, Hironori Akiyama, Hiroshi Igaki
Summary: This report presents a case study of a patient with T3N2cM0 tongue cancer who was effectively treated using concurrent chemoradiotherapy and boost high-dose rate interstitial brachytherapy. The authors believe that by carefully planning the radiation therapy to minimize mandible dose and combining it with a mouthpiece to protect the mandible, T3N2 disease can be treated, offering a treatment option for patients who wish to preserve organ function.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
