Journal
BONE MARROW TRANSPLANTATION
Volume 53, Issue 7, Pages 832-837Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41409-018-0092-x
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Funding
- German Jose Carreras Foundation
- Meredith A. Cowden foundation
- Mallinckrodt
- Incyte Inc.
- Gilead Sciences, Inc.
- Jazz Pharmaceuticals
- Miltenyi
- Metabolon
- Beckman Coulter
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094260, R01HL129061] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI033484] Funding Source: NIH RePORTER
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Biomarkers are increasingly used for diagnosis and treatment of transplant-related complications including the first biomarker-driven interventional trials of acute graft-versus-host disease (GvHD). In contrast, the development of biomarkers of chronic GvHD (cGvHD) has lagged behind due to a broader variety of manifestations, overlap with acute GvHD, a greater variation in time to onset and maximum severity, and lack of sufficient patient numbers within prospective trials. An international workshop organized by a North-American and European consortium was held in Marseille in March 2017 with the goal to discuss strategies for future biomarker development to guide cGvHD therapy. As a result of this meeting, two areas were prioritized: the development of prognostic biomarkers for subsequent onset of moderate/severe cGvHD, and in parallel, the development of qualified clinical-grade assays for biomarker quantification. The most promising prognostic serum biomarkers are CXCL9, ST2, matrix metalloproteinase-3, osteopontin, CXCL10, CXCL11, and CD163. Urine-proteomics and cellular subsets (CD4(+) T-cell subsets, NK cell subsets, and CD19(+)CD21(low) B cells) represent additional potential prognostic biomarkers of cGvHD. A joint effort is required to verify the results of numerous exploratory trials before any of the potential candidates is ready for validation and subsequent clinical application.
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