Article
Clinical Neurology
Jian Guan, Chenghua Yuan, Yueqi Du, Shanhang Jia, Can Zhang, Zhenlei Liu, Kai Wang, Wanru Duan, Zuowei Wang, Xingwen Wang, Hao Wu, Zan Chen, Fengzeng Jian
Summary: This study investigated the incidence, distribution, and radiological characteristics of dural ossification (DO) associated with ossification of the posterior longitudinal ligament (OPLL). The results showed that DO was relatively common in cervical OPLL, and the parenthese sign (PS) and hook sign (HS) had high diagnostic accuracy.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Yun Hee Choi, Je Hoon Lee, Young Min Kwon
Summary: This study evaluated the prevalence of ossification of the spinal ligament in healthy Koreans using whole-body PET-CT. The results showed that the prevalence of OPLL and OLF in Korean subjects was consistent with that in other Asian countries. Furthermore, the presence of spinal ossification in different locations was correlated to some extent.
Article
Clinical Neurology
Toru Asari, Kanichiro Wada, Gentaro Kumagai, Eiji Sasaki, Rino Okano, Tetsushi Oyama, Manami Tsukuda, Kento Ota, Yasuyuki Ishibashi
Summary: This study compared the accuracy of digital tomosynthesis (DTS), radiography, and computed tomography (CT) for the diagnosis and classification of cervical OPLL (C-OPLL). The results showed that DTS may be an alternative to CT for the diagnosis and classification of C-OPLL by specialists. However, caution should be taken when diagnosing and classifying C-OPLL using radiography and DTS by residents, and the use of CT is recommended.
EUROPEAN SPINE JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Wen Yan, Dong-Ya Li, Wang-Yi Jin, Chao-Ran Huang, Sheng Pan, Da -Lin Peng, Xing-Chen Zhang, Yong Pang, Kai-Jin Guo, Xin Zheng
Summary: The prevalence of incidental thyroid abnormalities in cervical MRI of DCS patients is 7.5%. Thyroid nodules are the most common abnormality, followed by goiters. Further ultrasound examination should be performed to determine the need for surgery.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Clinical Neurology
Shotaro Fukada, Tsutomu Endo, Masahiko Takahata, Masahiro Kanayama, Yoshinao Koike, Ryo Fujita, Ryota Suzuki, Toshifumi Murakami, Tomoka Hasegawa, Mohamad Alaa Terkawi, Tomoyuki Hashimoto, Kastuhisa Yamada, Hideki Sudo, Ken Kadoya, Norimasa Iwasaki
Summary: This study found an association between dyslipidemia and symptomatic OPLL, suggesting that visceral fat obesity or abnormal lipid metabolism may be involved in the pathogenesis of OPLL.
Article
Clinical Neurology
Gil Kimchi, Tomer Maimon, Liat Lerner Geva, Nachshon Knoller, Anton Peled, Gal Yaniv, Alon Orlev, Maximiliano Klug, Ran Harel
Summary: This study investigated the prevalence and characteristics of cervical ossified posterior longitudinal ligament (COPLL) in the Jewish population. The results showed a prevalence rate of 7.5% in the Jewish population, which is significantly higher than other populations. There was a prominent genetic contribution to the development of COPLL in this population. This is the first study to identify an increased prevalence of COPLL in the Jewish population.
WORLD NEUROSURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Choong Guen Chee, Min A. Yoon, Kyung Won Kim, Yusun Ko, Su Jung Ham, Young Chul Cho, Bumwoo Park, Hye Won Chung
Summary: The combined radiomics-clinical model showed good calibration and discrimination in predicting malignancy of vertebral compression fractures on CT. It outperformed both the radiomics score and clinical predictor model in terms of discrimination performance and accurately stratified patients into low and high risk groups.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Zhang, Yongye Chen, Xiaoying Xing, Qizheng Wang, Ke Liu, Enlong Zhang, Ning Lang
Summary: This study investigated the imaging manifestations and clinicopathological findings of primary leiomyosarcoma of the spine, finding that the most common clinical symptom is focal pain. Imaging features include solitary tumor lesions, lobulated masses with osteolytic bone destruction and ill-defined borders. The tumor and spinal cord appear isointense on T1WI and T2WI, with contrast-enhanced scanning showing homogeneous enhancement. The study found that the lesion tends not to recur after complete tumor resection.
INSIGHTS INTO IMAGING
(2022)
Article
Clinical Neurology
Yuichiro Hisada, Tsutomu Endo, Yoshinao Koike, Masahiro Kanayama, Ryota Suzuki, Ryo Fujita, Katsuhisa Yamada, Akira Iwata, Hiroyuki Hasebe, Hideki Sudo, Norimasa Iwasaki, Masahiko Takahata
Summary: The radiographic progression pattern and risk factors of thoracic ossification of the posterior longitudinal ligament (OPLL) differ from cervical OPLL. Young age and high BMI are significant risk factors for OPLL progression.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Sarah Mezghani, Marjorie Salga, Mickael Tordjman, Raphael Amar, Robert-Yves Carlier, Lea Chiche
Summary: This study explored the imaging features of heterotopic ossification (HO) in severe COVID-19 patients, mainly located around the hips with rare vessel and nerve invasion. The study found similarities in morphological aspects between COVID-19-related HOs and those caused by other disorders, but differences in the level of local invasion.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Surgery
Jia-lin He, Qian Du, Wan-dong Hu, Zhi-jun Xin, Xin-xin Shao, Wen-bo Liao
Summary: This study evaluated the efficacy of posterior percutaneous full-endoscopic technique for patients with thoracic myelopathy caused by ossification of ligamentum flavum (TOLF). The results showed that endoscopic surgery has a good clinical effect on TOLF, with minimal impact on the spinal structure.
Article
Medicine, General & Internal
Florian A. A. Huber, Cynthia S. S. Schmidt, Hatem Alkadhi
Summary: This study aimed to evaluate the diagnostic performance and inter-reader agreement of a novel "Darth Vader sign" for detecting spondylolysis in non-musculoskeletal abdominal CT imaging. The results showed that the Darth Vader sign demonstrated good inter-reader agreement and excellent diagnostic capabilities with high sensitivity and specificity for detecting spondylolysis.
Article
Multidisciplinary Sciences
Hirotsugu Sakamoto, Makoto Nishimura, Alexei Teplov, Galen Leung, Peter Ntiamoah, Emine Cesmecioglu, Noboru Kawata, Takashi Ohnishi, Ibrahim Kareem, Jinru Shia, Yukako Yagi
Summary: Endoscopic submucosal dissection is an effective method for treating large superficial gastrointestinal lesions. This study successfully generated three-dimensional images of nine samples using a micro-CT imaging system, which can provide valuable information for evaluating the extent of the lesion and surgical margins.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Jan-Christoph Backhauss, Olav Jansen, Hans-Ulrich Kauczor, Sam Sedaghat
Summary: This study investigated the association between non-traumatic vertebral body fractures and degenerative changes in older patients. The results show that fatty deposits in the lower thoracic and lumbar spine are associated with non-traumatic fractures of the lower thoracic spine, but not with lumbar spine fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sodai Hoshiai, Shouhei Hanaoka, Tomohiko Masumoto, Yukihiro Nomura, Kensaku Mori, Yoshikazu Okamoto, Tsukasa Saida, Toshitaka Ishiguro, Masafumi Sakai, Takahito Nakajima
Summary: Temporal subtraction computed tomography (TS CT) using deep learning is effective in improving the detection of vertebral bone metastasis. The study shows that TS CT significantly improves the detection of osteoblastic lesions and vertebral arch abnormalities.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Clinical Neurology
Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi
Summary: The study showed that PPS fixation augmented with HA granules significantly increased the maximal pullout strength and maximal insertion torque, while decreasing the incidence of screw loosening in osteoporotic spine.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Toshimi Aizawa, Toshimitsu Eto, Ko Hashimoto, Haruo Kanno, Eiji Itoi, Hiroshi Ozawa
Summary: This study compared surgical outcomes of thoracic OPLL patients treated with posterior decompression with instrumented spinal fusion (PDF) and the authors' technique using anterior decompression through a posterior approach. The modified Ohtsuka procedure showed significantly better results for patients who could not walk preoperatively than PDF.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Orthopedics
Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Kyoichi Handa, Kohei Takahashi, Takahiro Onoki, Eiji Itoi, Hiroshi Ozawa
Summary: The modified Ohtsuka procedure has shown better surgical outcomes and safety in the treatment of thoracic myelopathy caused by ossification of the posterior longitudinal ligament compared to posterior decompression with instrumented spinal fusion (PDF). Patients who underwent the modified Ohtsuka procedure had significantly higher rates of neurological recovery compared to PDF.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Clinical Neurology
Takashi Hirai, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Yukihiro Nakagawa, Kanichiro Wada, Keiichi Katsumi, Kengo Fujii, Atsushi Kimura, Takeo Furuya, Narihito Nagoshi, Tsukasa Kanchiku, Yukitaka Nagamoto, Yasushi Oshima, Kei Ando, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Shunji Matsunaga, Takashi Kaito, Kei Yamada, Sho Kobayashi, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Shiro Imagama, Masao Koda, Yoshiharu Kawaguchi, Katsushi Takeshita, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: This study is the first large-scale, prospective, multicenter case series study to investigate factors influencing preoperative neurological status in patients with cervical ossification of the posterior longitudinal ligament (OPLL). The study found that age and signal intensity change on magnetic resonance imaging were significantly associated with Japanese Orthopedic Association (JOA) score in patients requiring surgery.
CLINICAL SPINE SURGERY
(2022)
Article
Clinical Neurology
Yuya Ishikawa, Masayuki Ohashi, Toru Hirano, Michiharu Matsuda, Takeru Akabane, Haruo Kanno, Ko Hashimoto, Kyoichi Handa, Toshimi Aizawa, Tomoto Suzuki, Yukihide Shimamura, Kei Watanabe
Summary: This retrospective study evaluated the mid- to long-term surgical outcomes of thoracic dumbbell tumors treated with laminectomy and unilateral total facetectomy without instrumented fusion. The results showed that this surgical approach did not cause spinal deformity or instability requiring additional surgery at the follow-up, and the surgical region did not have adverse effects on the outcomes.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Kanji Mori, Toshitaka Yoshii, Takashi Hirai, Satoshi Maki, Keiichi Katsumi, Narihito Nagoshi, Soraya Nishimura, Kazuhiro Takeuchi, Shuta Ushio, Takeo Furuya, Kei Watanabe, Norihiro Nishida, Kota Watanabe, Takashi Kaito, Satoshi Kato, Katsuya Nagashima, Masao Koda, Kenyu Ito, Shiro Imagama, Yuji Matsuoka, Kanichiro Wada, Atsushi Kimura, Tetsuro Ohba, Hiroyuki Katoh, Yukihiro Matsuyama, Hiroshi Ozawa, Hirotaka Haro, Katsushi Takeshita, Masahiko Watanabe, Morio Matsumoto, Masaya Nakamura, Masashi Yamazaki, Atsushi Okawa, Yoshiharu Kawaguchi
Summary: This multicenter cross-sectional study examined the characteristics of young patients with cervical OPLL in terms of imaging features, subjective symptoms, and ADL problems. The study found that the young group (<= 45 years old) accounted for 9.7% of the total patients and had high BMI, significant involvement of trauma in symptom onset and deterioration, lower bodily pain score in female patients, and a predominance of thoracic OPLL.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Orthopedics
Kyoichi Handa, Haruo Kanno, Shigetsune Matsuya, Hideki Imaizumi, Eiji Itoi
Summary: The prevalence of pre-existing factors, such as OPLL, development stenosis, and posterior spur, is significantly higher in cervical spinal cord injury (CSCI) patients without bone injury compared to those with bone injury. These pre-existing factors might be potential risk factors for CSCI without bone injury.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Letter
Clinical Neurology
Haruo Kanno
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa
Summary: This study reports a novel surgical technique for managing thoracic myelopathy due to ossification of the posterior longitudinal ligament (OPLL). The technique involves anterior decompression through a posterior approach to achieve anterior shift of the OPLL. The preliminary outcomes of this technique show improved ambulatory status and Japanese Orthopaedic Association (JOA) scores in patients with thoracic OPLL, with no postoperative neurological deterioration.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Multidisciplinary Sciences
Hiroaki Nakashima, Shiro Imagama, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Yukihiro Nakagawa, Takashi Hirai, Kanichiro Wada, Keiichi Katsumi, Kengo Fujii, Atsushi Kimura, Takeo Furuya, Tsukasa Kanchiku, Yukitaka Nagamoto, Yasushi Oshima, Narihito Nagoshi, Kei Ando, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Shunji Matsunaga, Takashi Kaito, Kei Yamada, Sho Kobayashi, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Yuanying Li, Hiroshi Yatsuya, Masao Koda, Yoshiharu Kawaguchi, Katsushi Takeshita, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: This multicenter study compares postoperative outcomes of patients with cervical ossification of the posterior longitudinal ligament, and finds that laminoplasty (LM) has lower risk of perioperative complications and C5 palsy occurrence, but higher risk of OPLL progression. LM and posterior fusion (PF) have comparable postoperative outcomes in terms of JOA scores, JOA recovery rate, and JOACMEQ improvement at 2 years after surgery.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kanji Mori, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Takashi Hirai, Yu Matsukura, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Satoshi Maki, Narihito Nagoshi, Norihiro Nishida, Yukitaka Nagamoto, Yasushi Oshima, Kei Ando, Hiroaki Nakashima, Masahiko Takahata, Hideaki Nakajima, Kazuma Murata, Masayuki Miyagi, Takashi Kaito, Kei Yamada, Tomohiro Banno, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Hiroshi Taneichi, Shiro Imagama, Yoshiharu Kawaguchi, Katsushi Takeshita, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: This study investigated the effects of obesity on surgical treatment of cervical OPLL and found that obese patients had a significantly higher rate of surgical site infection compared to non-obese patients.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa
Summary: Osteoporosis is a common disease in elderly populations and can cause complications in spinal fusion surgeries. Techniques and materials to enhance screw fixation in osteoporotic patients are necessary.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Haruo Kanno, Kyoichi Handa, Taishi Murakami, Toshimi Aizawa, Hiroshi Ozawa
Summary: Autophagy is an important cellular function involved in the degradation of proteins and organelles. Chaperone-mediated autophagy (CMA) specifically degrades proteins and plays a crucial role in maintaining cellular proteostasis. Dysfunction of CMA is associated with the accumulation of toxic protein aggregates in the central nervous system (CNS) and contributes to the pathogenesis of neurodegenerative diseases. Recent studies have shown that CMA activity is upregulated in damaged neural tissue following acute neurological insults, suggesting its role in neuroprotection. Enhancing CMA pathway may have therapeutic potential for both neurodegenerative diseases and acute neurological injuries.
Article
Clinical Neurology
Narihito Nagoshi, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Takashi Hirai, Yu Matsukura, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Satoshi Maki, Norihiro Nishida, Yukitaka Nagamoto, Yasushi Oshima, Kei Ando, Hiroaki Nakashima, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Masayuki Miyagi, Takashi Kaito, Kei Yamada, Tomohiro Banno, Satoshi Kato, Tetsuro Ohba, Satoshi Inami, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Kota Watanabe, Hiroshi Taneichi, Shiro Imagama, Yoshiharu Kawaguchi, Katsushi Takeshita, Masaya Nakamura, Morio Matsumoto, Masashi Yamazaki, Atsushi Okawa
Summary: This study aims to evaluate patient-reported outcomes using the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) and clarify clinical factors that affect the therapeutic effects for patients with cervical ossification of the posterior longitudinal ligament (OPLL). The results showed that younger age and a postoperative decrease in arm or hand pain were correlated with significantly improved function of the upper extremities, while a reduction in lower limb pain favorably affected the postoperative lower extremity function. A postoperative reduction in upper extremity pain enhanced the quality of life (QOL) recovery.
Review
Medicine, General & Internal
Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa
Summary: In percutaneous pedicle screw (PPS) fixation of the osteoporotic spine, obtaining sufficient stability is challenging in patients with severe osteoporosis. Currently, there is no established augmentation method for PPS fixation. We developed a novel technique using HA granules to enhance PPS fixation and applied it in various spine surgeries. Biomechanical analyses demonstrated significant improvement in stability and reduced incidence of screw loosening and implant failure following augmentation with HA granules.
MEDICINA-LITHUANIA
(2022)