Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Efficacy and safety of diclofenac sodium 2% topical solution for osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled, 4 week study

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Hyaluronan inhibits IL-1β-stimulated collagenase production via down-regulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells

(2014) Sohel M. Julovi et al.   Modern Rheumatology

Penetration of topical diclofenac sodium 4 % spray gel into the synovial tissue and synovial fluid of the knee: a randomised clinical trial

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A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

(2012) V. Strand et al.   OSTEOARTHRITIS AND CARTILAGE

Long-term tolerability of topical diclofenac sodium 1% gel for osteoarthritis in seniors and patients with comorbidities

(2012) John Peniston et al.   Clinical Interventions in Aging

SA14867, a newly synthesized kappa-opioid receptor agonist with antinociceptive and antipruritic effects

(2010) Yaeko Tsukahara-Ohsumi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

OARSI recommendations for the management of hip and knee osteoarthritis

(2010) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production

(2009) M. Hashizume et al.   OSTEOARTHRITIS AND CARTILAGE

Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and oral applications

(2008) Shin Miyatake et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13

(2008) Hironari Takaishi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E2 production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

(2008) Yasuhiro Mitsui et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment

(2008) T.N. de Boer et al.   OSTEOARTHRITIS AND CARTILAGE