Article
Genetics & Heredity
Jessika Nordin, Mats Pettersson, Lina Hultin Rosenberg, Argyri Mathioudaki, Asa Karlsson, Eva Muren, Karolina Tandre, Lars Ronnblom, Alf Kastbom, Jan Cedergren, Per Eriksson, Peter Soderkvist, Kerstin Lindblad-Toh, Jennifer R. S. Meadows
Summary: This study investigated the role of MHC in ankylosing spondylitis through typing 17 genes, identifying 25 HLA protein-coding variants associated with the disease. Novel protective associations were found in a HLA-B*27 positive population, and unique risk variants were identified in different sexes, highlighting the impact of population composition on disease associations.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Haseeb Chaudhary, Clementina Lopez-Medina, Muhammad Asim Khan, Maxime Dougados, Marina Magrey
Summary: In a global axSpA cohort, HLA-B*27 (-) patients had a longer delay in diagnosis, more frequently had peripheral arthritis, enthesitis, IBD, and psoriasis, and were more often treated with csDMARDs compared to the HLA-B*27 (+) subgroup.
Article
Biochemistry & Molecular Biology
Gabriela Angelica Martinez-Nava, Yessica Zamudio-Cuevas, Ninoska Aleida Terrazas-Ontiveros, Karina Martinez-Flores, Rolando Espinosa-Morales, Fernando Mijares-Diaz, Shaila Monserrat Juarez-Barreto, Carlos Lozada-Perez, Margarita Valdes-Flores, Roberto Sanchez-Sanchez, Alberto Hidalgo-Bravo, Javier Fernandez-Torres
Summary: HLA-B*27 tag-SNPs are associated with susceptibility to ankylosing spondylitis, with rs4349859 SNP showing outstanding performance in detecting HLA-B*27 and can be proposed as a screening marker. ERAP1 polymorphisms did not show significant associations.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Immunology
JiaoJiao Lu, Jing Yang, WenXu Dong, BaoJia Tang, LuoYuan Cao, YingHua Lin, BaoYing Huang, XianGuo Fu
Summary: The study investigated the polymorphism and distribution of HLA-B*27 alleles in Han patients with ankylosing spondylitis in southeastern China. The overwhelming frequency of HLA-B*2704 was identified in AS patients, with a possible origin from southern Han populations and migration to northern areas, while HLA-B*2705 showed the opposite distribution pattern.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Multidisciplinary Sciences
Xinbo Yang, Lee I. I. Garner, Ivan V. V. Zvyagin, Michael A. A. Paley, Ekaterina A. A. Komech, Kevin M. M. Jude, Xiang Zhao, Ricardo A. A. Fernandes, Lynn M. M. Hassman, Grace L. L. Paley, Christina S. S. Savvides, Simon Brackenridge, Max N. N. Quastel, M. M. Chudakov, Paul Bowness, Wayne M. M. Yokoyama, Andrew J. J. McMichael, Geraldine M. M. Gillespie, K. Christopher Garcia
Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Health Care Sciences & Services
Janisleya Silva Ferreira Neves, Jeane Eliete Laguila Visentainer, Denise Manjurma da Silva Reis, Marco Antonio Rocha Loures, Hugo Vicentin Alves, Joana Maira Valentini Zacarias, Ana Maria Sell
Summary: The IL17F C variant was found to be a significant risk factor for SpA in Brazilian patients who were HLA-B*27 negative, potentially serving as a marker for SpA. Additionally, the VDR gene ApaI a/a genotype was identified as a potential risk factor for SpA in men.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Rheumatology
Praveena Chiowchanwisawakit, Manop Pithukpakorn, Komon Luangtrakool, Parichart Permpikul
Summary: The study found that HLA-B*27:04 and HLA-B*27:05 were strongly associated with Thai AS patients, while HLA-B*27:06 showed no association. Additionally, patients carrying HLA-B*27:04 were more likely to have enthesitis and a younger age of onset compared to those carrying HLA-B*27:05.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
M. L. Stoll, H. Sawhney, P. M. Wells, P. R. Sternes, J. D. Reveille, C. D. Morrow, C. J. Steves, M. A. Brown, L. S. Gensler
Summary: Objective: The objective of this study was to evaluate the contents of the faecal microbiota in HLA-B27+ AS patients and healthy adults, and to assess the impact of HLA-B27 on the microbiota.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami
Summary: This study aimed to assess the efficacy of an IL17A peptide-based vaccine on SpA manifestations in model rats. The results showed that the IL17A peptide-based vaccine successfully induced antibody production and suppressed the arthritis score and joint thickness. It also inhibited enthesitis, bone destruction, and new bone formation. The study suggests that the IL17A peptide-based vaccine may be a therapeutic option for SpA treatment.
Article
Rheumatology
Juergen Braun, Joachim Sieper
Summary: The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex. It is associated with ankylosing spondylitis (AS) and plays a role in the immune system's defense against microbes. HLA B27 accounts for less than 30% of the genetic load and can be found in 60-90% of axSpA patients worldwide. Its prevalence in the population is linked to the prevalence of the disease.
Article
Rheumatology
Marta Arevalo Salaet, Clementina Lopez-Medina, Mireia Moreno, Victoria Navarro-Compan, Joan Calvet Fontova, Maria Llop, Maxime Dougados, Jordi Gratacos
Summary: This study analyzed the influence of HLA-B27 in the phenotypical expression of pSpA. The results showed that HLA-B27-positive patients had an earlier disease onset and higher axial involvement, tarsitis, and uveitis, but no association with other EMM, fibromyalgia, or peripheral structural damage was observed.
Review
Immunology
Fatemeh Navid, Vance Holt, Robert A. Colbert
Summary: Establishing a clear role for HLA-B*27 in the pathogenesis of spondyloarthritis remains challenging, with recent studies suggesting potential links to abnormal bone formation and increased osteoblast mineralization. Further research is needed to fully understand the mechanisms behind these associations.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Medicine, General & Internal
Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Qing Lv, Pingping Zhang, Xuqi Zheng, Zena Chen, Shuangyan Cao, Liudan Tu, Jieruo Gu
Summary: This study investigated the HLA-B genotypes of Chinese individuals and found HLA-B*27:04 to be the dominant subtype. HLA-B*40:01, HLA-B*46:01, and HLA-B*15:02 were identified as potential diagnostic indicators for ankylosing spondylitis (AS).
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Muhammad A. Khan
Summary: This article reviews the 50th anniversary of the discovery of the strong association between HLA-B*27 and AS, summarizes the recent findings, and highlights the presence of clonally expanded CD8+ T cells in AS patients who carry the HLA-B*27 gene. The study also reveals the distinct affinity of the T-cell receptors alpha and beta chain motifs for specific peptides, leading to an autoimmune response and the onset of the disease.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Chemistry, Physical
Qiangqiang Nie, Guohong Chen, Bing Wang, Lei Yang, Jianhua Zhang, Wenming Tang
Summary: Cu/Invar bi-metal matrix composites show great potential as novel electronic packaging materials. The size of Invar particles affects the microstructures and properties of the composites, with finer Invar particles leading to finer Cu grain sizes and improved thermal conductivity. Sintering temperature also plays a critical role in determining the properties of the composites, with 700 degrees Celsius sintered composites exhibiting the highest thermal conductivity.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Haiyang Xia, Baohua Yang, Yunlong Li, Bing Wang
Summary: This study proposes a model called MobileNet_CenterNet for insulator and defect detection by unmanned aerial vehicles in power inspection. By using a lightweight network, introducing attention mechanism, and adding transposed convolution modules, the model achieves improved detection accuracy and inference speed.
Article
Biochemistry & Molecular Biology
Fu-Sheng Liu, Chang Jiang, Zheng Li, Xiao-Bin Wang, Jing Li, Bing Wang, Guo-Hua Lv, Fu-Bing Liu
Summary: This study establishes an in vitro model to explore the relationship among spinal cord injury, intracellular calcium ions, and autophagy. Mechanical injury is found to promote the increase of intracellular calcium concentration, which activates autophagy through the CaMKK beta/AMPK/mTOR pathway and also triggers apoptosis. This study provides new insights into the mechanisms of spinal cord injury and opens up new possibilities for its treatment.
NEUROCHEMICAL RESEARCH
(2023)
Article
Engineering, Industrial
Bing Wang, Yuanjie Wang, Fang Yan
Summary: In recent years, safety intelligence has gained increasing research attention as the backbone of safety management. Big data and related technologies have had considerable influence on safety intelligence and management. This study discusses the influence of big data on various aspects of safety intelligence and presents an analysis of the challenges faced in traditional safety management. It also introduces the concept of intelligence-led safety management (ILSM) and discusses its value and the function of big data within ILSM. A model for ILSM in a big-data environment is proposed, along with a mention of an intelligent urban safety management system as an application case.
Article
Physics, Applied
Jie Yang, Zhaoquan Chen, Tao Dai, Sile Chen, Weiye Wang, Qingchun Su, Lu Zhang, Bing Wang, Yuming Zhou, Xinpei Lu
Summary: In this study, a dual-channel pulsed microwave coaxial resonant discharge device was constructed to generate atmospheric pressure pulsed microwave He plasma jet and spatially layered He/N-2 plasma jet. The spatiotemporal ionization evolution process of the He/N-2 plasma jet was determined in experiments. These results provide important references for better understanding the physical characteristics of gas plasma jets.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Engineering, Industrial
Bing Wang, Miaoting Yun, Qiong Liu, Yuanjie Wang
Summary: Precision is the ultimate goal of safety management. Technological advances have enabled safety managers to pursue and achieve precise safety management based on sufficient and accurate information. Developing novel approaches to precise prevention and control of safety risks is an inevitable trend. This paper proposes a new approach called precision safety management (PSM) and applies it to a case study in a chemical industrial park. The contributions of this study are a theoretical framework for PSM and a practical application of PSM.
Article
Materials Science, Multidisciplinary
Huanjun Lu, Hui Zou, Xingwei Chen, Wenhao Zhang, Bingbing Wang, Zhaoliang Cao, Yingfeng Tu
Summary: In this study, liquid crystalline binary mixtures of [60]fullerene with a wedge-shaped tris-(alkyl)gallate group were investigated. The phase behavior was determined by the volume fraction of the hydrocarbon moiety, and a transition from a low-temperature lamellar phase to a high-temperature phase was observed. Crystal melting behavior suggested a preference for the longer-chain component to occupy the outer layer of the lamellar phase. The research provides a way to adjust the cross-sectional ratio and tailor the level of cross-sectional mismatch for further soft matter self-assembly modes.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Crystallography
Zuoru Dong, Yangzhou Zhou, Yulu Chen, Jiajia Tao, Wenhui Liu, Xiaowan Dai, Bingbing Wang, Yifei Wu, Xiaodong Wang
Summary: An anti-reflection coating was designed for a back-illuminated Si-based BIB detector in the VLWIR range. The reflectance and transmittance spectra of ZnS films of different thicknesses on Si substrates were studied through simulation and experiment. The results showed significant reduction in reflectance and increase in transmittance for Si coated with ZnS films of various thicknesses, leading to enhanced transmission and improved spectral responsivity of the BIB detector.
Article
Thermodynamics
Yu Xu, Zijun Li, Gang Li, Saeid Jalilinasrabady, Xiaowei Zhai, Yin Chen, Bing Wang
Summary: This study presents a numerical method to analyze the airflow and surrounding rock temperatures in underground roadways. By approximating the ventilation roadway as a one-dimensional line element, the modeling effort and computation time are reduced while maintaining the three-dimensional nature of the surrounding rock. The predicted airflow temperature shows good agreement with field measurements. The study also investigates the impact of ventilation time on the underground thermal environment.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Liuwei Wang, Zhouyi Wang, Bingcheng Wang, Qingsong Yuan, Zhiyuan Weng, Zhendong Dai
Summary: The study investigates the reversible adhesion/release behavior and structural properties of gecko toes. A hierarchical adhesive bionic toe is designed, which can adhere to and release from targets reversibly. The bio-toe shows good adaptability, load capacity, and reversibility of adhesion.
Article
Engineering, Electrical & Electronic
Jinjun Duan, Bingcheng Wang, Baolin Ji, Weidong Sun, Zhouyi Wang, Zhendong Dai
Summary: With the increasing storage capacity of oil tanks and wind turbine towers worldwide, the maintenance of these structures has become a problem. Wall-climbing robots are the ideal solution due to their ability to adhere to vertical surfaces. However, the curvature of the curved surface poses a challenge to the robot's stability. This paper proposes an adaptive external force-softening motion strategy to improve the robot's stability during vertical arc crawling.
IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE
(2023)
Article
Chemistry, Physical
Bingcheng Wang, Wei Shao, Qun Cao, Zheng Cui
Summary: This study investigates the effect of interfacial thermal resistance (ITR) on the thermal conductivity of graphene/epoxy nanocomposites. The graphene concentration is found to have a slight influence on the thermal conductivity. By modifying the graphene edge with amino groups, the interfacial heat transfer coefficient is increased, leading to improved thermal conductivity. Vacancy defects and covalent interactions are also utilized to decrease graphene-graphene ITR and increase the thermal conductivity.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Thermodynamics
Bingcheng Wang, Wei Shao, Qun Cao, Zheng Cui
Summary: Graphene networks have the potential to improve the thermal transport of epoxy matrix composites. However, the low heat transfer efficiency between adjacent graphene, especially in intersected structures, limits its application. This study investigates the thermal transport of intersected graphene and explores the effects of nodal gap width, number and distribution of crosslinking bonds, and intersecting angle on the heat transfer coefficient. The findings reveal that the coupling between intersected graphene changes from Van der Waals interactions to covalent interactions, and the heat transfer efficiency is influenced by the number and distribution of crosslinking bonds.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Engineering, Biomedical
Bingcheng Wang, Zhouyi Wang, Yifan Song, Weijia Zong, Linghao Zhang, Keju Ji, Poramate Manoonpong, Zhendong Dai
Summary: Climbing behavior is a skill evolved by animals to improve their position in complex natural environments. Current bionic climbing robots lack agility, stability, and energy efficiency compared to animals. Inspired by geckos, a climbing robot with active attachment-detachment bionic flexible feet has been developed, using a modular neural control framework to achieve proper coordination and limb-to-foot collaboration. The experiments show that the robot with neural control achieved higher adhesion area and reliability, enhancing its climbing ability.
CYBORG AND BIONIC SYSTEMS
(2023)
Article
Optics
Wenhui Yu, Xiang Li, Bing Wang, Yanping Li, Binglin Shen, Junle Qu, Liwei Liu
Summary: Polarization-sensitive second-harmonic-generation microscopy (pSHGM) allows for the determination of molecular orientation. A wide-field pSHGM measurement scheme has been proposed to measure the second-order nonlinear polarization tensor, eliminating the assumptions of sample symmetry. The ability to record second harmonic signals simultaneously enables higher imaging frame rates compared to traditional point scanning methods.