Article
Pharmacology & Pharmacy
Yu Mei, Xijia Feng, Tienan Feng, Min Yan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: This retrospective study examined the role of adjuvant chemotherapy (ACT) in patients with pT2N0M0 gastric cancer who underwent radical resection. The study found that ACT was associated with higher 5-year overall survival and disease-specific survival rates. Patients with pT2N0M0 gastric cancer, regardless of high-risk factors, may be suitable for ACT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Qifei He, Jiahui Chen, Kai Zhou, Chenggen Jin, Anqiang Wang, Ke Ji, Xin Ji, Ji Zhang, Xiaojiang Wu, Xia Li, Zhaode Bu, Jiafu Ji
Summary: This study compared the efficacy of chemotherapy with trastuzumab in HER2-positive gastric cancer patients in the AT and NAT settings, showing that AT patients benefited from the combination with trastuzumab in terms of overall survival, while NAT patients showed improvements in tumor pathological regression and staging.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Haoran Li, Fang Zhou, Zhifei Cao, Yuchen Tang, Yujie Huang, Ye Li, Bin Yi, Jian Yang, Peng Du, Dongming Zhu, Jian Zhou
Summary: This study developed and validated a nomogram using preoperative nutritional indicators and tumor markers to predict prognosis of PDAC patients. The nomogram performed better in predicting overall survival compared to CONUT and PNI.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi Zhang, Fei-Fei Kong, Zheng-Qiu Zhu, Hai-Xia Shan
Summary: CONUT score is an independent prognostic indicator for poor outcomes in stage III-IV NSCLC patients undergoing first-line chemotherapy. High CONUT score is associated with older age, worse ECOG-PS, advanced clinical stage, higher SII, and lower PNI. CONUT score shows better accuracy in predicting PFS and OS compared to SII and PNI.
Article
Nutrition & Dietetics
Olivia Di Vincenzo, Ermenegilda Pagano, Mariarosaria Cervone, Raffaele Natale, Annadora Morena, Alessandra Esposito, Fabrizio Pasanisi, Luca Scalfi
Summary: This study aimed to investigate the relationship between nutritional risk and functional status in stroke patients at admission to a rehabilitation unit. The study found a high prevalence of nutritional risk in stroke patients, with older patients having a higher risk. Nutritional risk was associated with functional status and predictors of clinical outcomes.
Article
Oncology
Peng Jin, Xiaoyan Ji, Shuai Ma, Wenzhe Kang, Hao Liu, Yang Li, Fuhai Ma, Haitao Hu, Weikun Li, Yantao Tian
Summary: This retrospective study analyzed gastric cancer patients with pathological stage pT1N1M0 and found that adjuvant chemotherapy may provide survival benefits for selected patients. Independent risk factors for reduced survival included sex, number of examined lymph nodes, and receiving AC. Patients were divided into three risk categories based on sex and lymph node status, with significant differences in survival observed between the groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Immunology
Huifang Liu, Jing Wu, Xiaoyu Xu, Han Wang, Changhua Zhang, Songcheng Yin, Yulong He
Summary: The study revealed that the infiltrated levels of TIGIT(+)CD20(+) B cells around tumors in gastric cancer patients were associated with clinical outcomes and could potentially impact the exhaustion of CD8(+) T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Jie Peng, Xiaoyu Li, Mingsheng Huang, Mincai Ma, Qin Huang, Ning Huang, Yuan Cheng
Summary: This meta-analysis evaluated the prognostic value of PNI and CONUT scores in patients with glioblastoma. The results showed that a high PNI score was associated with longer overall survival and progression-free survival, while a low CONUT score was associated with longer overall survival. Multivariate analyses confirmed that high PNI score and low CONUT score were independently associated with longer overall survival. Therefore, PNI and CONUT scores have prognostic value in patients with glioblastoma, but further large-scale studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao Zhang, Shutao Zhao, Xudong Wang
Summary: The study developed a prognostic nomogram based on extensive data analysis to effectively predict postoperative prognosis of patients with early gastric cancer (EGC). Using the nomogram, patients can be divided into low-, moderate-, and high-risk groups, with moderate- and high-risk patients benefiting from adjuvant chemotherapy (ACT) while low-risk patients do not require it.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Toshizo Takayama, Yasushi Tsuji
Summary: Surgical resection is the best curative option for gastric cancer, but patients with advanced disease have poor prognosis even after surgery. To reduce the risk of recurrence, perioperative chemotherapy has been combined with surgery, and different standard chemotherapy regimens have been developed in East Asia, Europe, and North America. In recent years, the use of novel agents such as molecular-targeted drugs and immune checkpoint inhibitors in perioperative therapy has shown promising results in these regions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Xinhao Niu, Zhe Zhu, Juan Bao
Summary: The CONUT score is associated with the prognosis of urological cancers, with a higher score indicating poorer survival outcomes for patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Jeanne Tie, Joshua D. Cohen, Kamel Lahouel, Serigne N. Lo, Yuxuan Wang, Suzanne Kosmider, Rachel Wong, Jeremy Shapiro, Margaret Lee, Sam Harris, Adnan Khattak, Matthew Burge, Marion Harris, James Lynam, Louise Nott, Fiona Day, Theresa Hayes, Sue-Anne McLachlan, Belinda Lee, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Ralph Hruban, Anne Marie Lennon, Nicholas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Cristian Tomasetti, Peter Gibbs
Summary: This study found that using ctDNA results to guide treatment decisions for stage II colon cancer reduced the use of adjuvant chemotherapy without compromising recurrence-free survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Keiji Nishibeppu, Shuhei Komatsu, Toshiyuki Kosuga, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji
Summary: This study evaluated the prognostic effect of cumulative total S-1 dose (CTSD) on adjuvant chemotherapy after curative gastrectomy. The findings suggest that a CTSD of more than 20000 mg may contribute to better prognosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Chunsheng Li, Mingchuan Wang, Xianbin Cheng, Yang Jiang, Huijie Xiao
Summary: This study retrospectively analyzed 350 patients with gastric cancer and found that perineural invasion (PNI) is an independent marker of poor prognosis in gastric cancer, correlated with T staging, lymph node metastasis, and lymphovascular invasion.
Article
Oncology
Guochao Ge, Guangyao Li, Zhengjun Zhang, Yong Zhu, Wentao Wang, Lei Ren, Ziqiang Li, Mujian Teng
Summary: This study evaluated the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on the prognosis of gastric cancer (GC). The findings show that a high PNI-NLR score can independently affect the worse prognosis of GC, and can be used to differentiate low risk from high risk subjects.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Immunology
Huilan Zeng, Deyao Zhang, Zhenyun Yang, Zili Hu, Zhoutian Yang, Yizhen Fu, Jingyu Hou, Siegmund Ngai, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Minshan Chen, Yaojun Zhang, Yangxun Pan
Summary: Serum cholesterol and C-reactive protein have been used as prognostic predictors for several malignancies, but their significance in hepatocellular carcinoma patients treated with ICIs-based hepatic artery infusion chemotherapy remains unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Zhenyun Yang, Deyao Zhang, Xiaoxian Sima, Yizhen Fu, Huilan Zeng, Zili Hu, Jingyu Hou, Yangxun Pang, Yaojun Zhang, Zhongguo Zhou, Minshan Chen, Dandan Hu
Summary: This study aimed to clarify the prognostic value of serum lipids and establish an effective nomogram for predicting overall survival in iCCA patients receiving anti-PD1 therapy. The results showed that serum lipid levels were associated with patient prognosis, with APOA1 and TG being significant independent predictors for overall survival in multivariate analysis. By constructing a predictive nomogram, the survival rate of iCCA patients can be more accurately predicted.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Deyao Zhang, Yangxun Pan, Zhenyun Yang, Huilan Zeng, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Minshan Chen, Dandan Hu
Summary: This study investigated the risk factors for post-hepatectomy liver failure (PHLF) by predicting and constructing an index to evaluate the risk. The independent predictive factors for PHLF included BMI, ICG-R15, INR, tumor size, HIO time, and operation method.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Oncology
Run-Cong Nie, Tian-Qi Luo, Guo-Dong Li, Fei-Yang Zhang, Guo-Ming Chen, Jin-Xing Li, Xiao-Jiang Chen, Zhou-Kai Zhao, Kai-Ming Jiang, Yi-Cheng Wei, Ming-Wei Hang, Shi Chen, Ying-Bo Chen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Engineering, Chemical
Junbo Cui, Yingbo Chen, Pengfei Guo, Wenxuan Su, Linzhe Xu, Yuanyuan Zhang
Summary: In order to address the issue of environmental pollution caused by waste reverse osmosis (RO) membranes, we recycled and reused the end-of-life RO membrane as a nanofiltration (NF) membrane through a cleaning-healing-interfacial polymerization (IP) method. The influence of different repair methods on the subsequent IP process and the performance of the NF membrane were discussed. The NF membrane prepared with 2.0 layers of self-assembled healed membranes showed excellent long-term stability, fouling resistance, and high rejection rates for Na2SO4 solutions of different concentrations, indicating its potential as a tight nanofiltration membrane. This work provides an economic and environmentally friendly approach for the future treatment of waste RO membrane modules.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Engineering, Chemical
Wenxuan Su, Lei Liu, Yingbo Chen, Junbo Cui, Xinyu Zhao
Summary: In this study, the speed of the interfacial polymerization reaction was controlled by controlling the diffusion rate of the aqueous monomer, thereby affecting the thickness and surface morphology of the polyamide layer. Polyethylene oxide (PEO) was added to increase the viscosity of the aqueous phase and slow down the reaction rate. Choline chloride (CC) was then grafted onto the surface of the polyamide membrane for secondary modification. The addition of 1% PEO resulted in the best performance of the composite membrane, and after CC modification, the rejection rate of (NaSO4)-S-2 was more than 96% with a permeation flux of 125.9 L/(m(2)center dot h center dot MPa). This composite membrane has potential applications in seawater desalination and sewage purification.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Engineering, Chemical
Meng Wang, Yingbo Chen, Wenxuan Su, Ke Zhao, Xianshe Feng
Summary: This study proposed a new method to enhance the treatment performance of chromium-containing wastewater by using sodium alginate (SA) encapsulated nano zero-valent iron particles (nZVI) loaded in the pores of aminated spherical magnesium hydroxide (MH-NH2). The prepared ternary composite showed great stability and dispersibility, and exhibited high efficiency in removing Cr(VI) from the solution under acidic conditions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Linzhe Xu, Yingbo Chen, Wenxuan Su, Junbo Cui, Siyu Wei
Summary: A mixed matrix membrane of amidoximized poly-acrylonitrile with MXene particles was prepared, which exhibited excellent selectivity and high adsorption capacity for U(VI) ions in natural seawater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Geochemistry & Geophysics
Shanbin He, Kun Meng, Ce Wang, Yingbo Chen, Hao Zhao, Haoyuan Wang, Hongyan Yu
Summary: The identification of reservoir fractures is crucial for designing a field development plan and improving the efficiency of hydrocarbon production. However, the lack of understanding of fracture development patterns in tight oil reservoirs in the Triassic Change 6 member of Y well area, Ordos Basin, China has led to issues such as water flooding and water channeling. This study analyzed cores from 20 wells, fractures, and outcrop profiles to identify controlling factors for fracture development and establish a fracture prediction method using conventional logging data. The findings indicate that fractures in this area have high angles, nearly east-west orientations, small spacing, small openings, small down-cutting depths, and a low filling rate. Thin beds and fine sandstones are prone to fracture development, and the modified curve change rate method is effective for fracture prediction in the Triassic Change 6 member tight sandstone reservoirs in the Y well area, Ordos Basin, China.
Article
Oncology
Jiaming Fang, Feiyang Zhang, Jun Lu, Zijian Deng, Xianzhe Li, Xijie Chen, Changming Huang, Yingbo Chen, Lei Lian, Junsheng Peng, Shi Chen
Summary: This study aimed to construct a prognostic model for prognosis prediction and assess the response to adjuvant chemotherapy (ACT) of stage II gastric cancer (GC) patients. Retrospective review of 547 stage II gastric cancer patients who underwent D2 radical gastrectomy was conducted. The nomogram performed well in prognosis prediction and stratified patients into high-risk and low-risk groups.
Article
Construction & Building Technology
Mingchao Li, Yingbo Chen, Mengxi Zhang, Lin Yang, Haojie Lian, Stephane P. A. Bordas, Rui Kong
Summary: This paper introduces a software platform called Hydraulic IsoGeometric Analysis (HIGA), which integrates geometric modeling, isogeometric analysis solution, and post-processing modules to enable engineers to design and analyze hydraulic structures in an integrated and interactive environment.
AUTOMATION IN CONSTRUCTION
(2023)
Article
Engineering, Environmental
Meng Wang, Yingbo Chen, Yuanyuan Zhang, Ke Zhao, Xianshe Feng
Summary: A new composite adsorbent for Cr(VI) removal was developed by immobilizing PEI on the surface of ZVI particles with TA as a stabilizer. The adsorbent showed excellent stability and high selectivity for Cr(VI) removal even after exposure to air for 30 days. The mechanism of Cr(VI) removal with Fe-TA-PEI-10 was based on adsorption and reduction, making it an efficient and long-lasting reactive adsorbent for Cr(VI) removal.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Pengfei Li, Yingbo Chen, Fan Xiao, Ming Cao, Jingyu Pan, Jingfeng Zheng, Hao Li, Ke Zhao, Xianglin Zhang, Yuanyuan Zhang
Summary: This study successfully prepared a flexible bifunctional material UiO-66-NH-SO3H with hydrophilic functionalized metal-organic frameworks, which was used to enhance the proton conductivity of proton exchange membranes (PEMs). By creating acid-base pairing interaction between UiO-66-NH-SO3H and SPEEK, an effective proton conduction channel was constructed, leading to high proton conductivity in the composite PEMs. The UiO-66-NH-SO3H/SPEEK = 40% composite PEMs showed the lowest methanol permeability and the highest proton selectivity.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yujia Feng, Qinghua Zhou, Feifei Mou, Yingbo Chen, Zhijing Xu
Summary: By comparing the blood specimens of 124 asthma patients, 124 chronic obstructive pulmonary disease patients, and 124 asthma-chronic obstructive pulmonary disease overlap syndrome patients, it was found that high mobility group box 1 levels were significantly elevated in the overlap syndrome group. High mobility group box 1 levels were also correlated with inflammation markers and lung function. Therefore, high mobility group box 1 is of clinical significance in the diagnosis and treatment of asthma-chronic obstructive pulmonary disease overlap syndrome.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Textiles
Chuanfeng Wang, Yingbo Chen, Meng Wang, Renhao Guo
Summary: A dual-layer PVDF loose nanofiltration hollow fiber membrane was designed and optimized through an online-coating device, and then cross-linked to improve solvent stability. The cross-linking process improved the stability in polar solvents with a slight decrease in thermal stability and mechanical properties. The prepared membranes showed excellent rejection of Rose bengal in various solvents and great stability for treatment of RB/ethanol solution, indicating their potential for organic solvent nanofiltration applications.
FIBERS AND POLYMERS
(2023)