Article
Oncology
Pierre Fwelo, Kenechukwu O. S. Nwosu, Toluwani E. Adekunle, Oladipo Afolayan, Onyekachi Ahaiwe, Akpevwe A. Ojaruega, Vignesh K. Nagesh, Ayrton Bangolo
Summary: This study examined the impact of race/ethnicity and socioeconomic status on surgical treatment types and treatment delays in breast cancer patients, and quantified the extent to which these differences explained disparities in breast cancer mortality. The study found that non-Hispanic Black and Hispanic women were more likely to undergo mastectomy and experienced higher treatment delays. Furthermore, variations in treatment, socioeconomic status, and clinicopathological factors explained 70% of the excess breast cancer-specific mortality among non-Hispanic Black women compared to non-Hispanic White women.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Margaret C. Schermerhorn, Miles W. Grunvald, Cristina M. O'Donoghue, Ruta D. Rao, Adan Z. Becerra
Summary: This study aimed to quantify the contribution of mediators that may explain racial/ethnic disparities in breast cancer treatment delays. The results showed that education, comorbidities, insurance, and facility type are the mediators contributing to these disparities. Efforts to equalize these factors could reduce the unfairness experienced by minority patients in terms of treatment delays.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Millie de Vries, Tiria Stewart, Theona Ireton, Karen Keelan, Jennifer Jordan, Bridget A. Robinson, Gabi U. Dachs
Summary: The aim of this study was to understand the research priorities for individuals living with cancer in New Zealand, with a focus on the Maori population. The participants saw cancer research as a high priority and expressed a desire for researchers to address their immediate and practical needs. The study found that the research priorities were similar between Maori and non-Maori participants, with some differences based on ethnicity.
Article
Oncology
Chelsea A. Obrochta, James D. Murphy, Ming-Hsiang Tsou, Caroline A. Thompson
Summary: This study found that patients of any race with lower socioeconomic status were at a substantially higher risk for undertreatment and treatment delay, and racial/ethnic disparities are reduced or eliminated among nonwhite patients living in the highest SES neighborhoods. Race/ethnicity explained a larger portion of the disparities in colorectal cancer treatment outcomes compared to neighborhood socioeconomic status.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Chunhuan Lao, Marion Kuper-Hommel, Mark Elwood, Ian Campbell, Melissa Edwards, Ross Lawrenson
Summary: The study in New Zealand found that patients with dnMBC had a longer survival compared to rMBC patients; ethnicity and socioeconomic status did not significantly impact breast cancer-specific mortality; patients with visceral metastases or triple negative disease had a poorer prognosis.
Article
Public, Environmental & Occupational Health
Siobhan O. Nnorom, Lori L. Wilson
Summary: Breast cancer is the most common noncutaneous malignancy affecting women in the United States, with the highest mortality rates observed in Black women. Survival after breast cancer is influenced by factors such as early detection and effective therapy, which are affected by both biological and social factors.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Sharita Meharry, Robert Borotkanics, Reena Ramsaroop, Fabrice Merien
Summary: This study showed that factors such as age, hormonal receptor status, and molecular subtypes can impact the five-year survival rates of patients with grade 3 breast cancer. Ethnicity also plays a role in the risk of mortality.
Article
Urology & Nephrology
Bashar Matti, Mataroria Lyndon, Kamran Zargar-Shoshtari
Summary: The study found significant ethnic disparities in prostate cancer screening rates in the Northern region of New Zealand, with Maori men having lower screening rates compared to non-Maori men. However, cancers detected in Maori men were more likely to be high-grade, indicating that ethnic factors can influence the clinical significance of cancers diagnosed.
Article
Oncology
Fei Wang, Wei Zheng, Christina E. Bailey, Ingrid A. Mayer, Jennifer A. Pietenpol, Xiao-Ou Shu
Summary: This study found that after considering clinical characteristics, treatment, and care-related factors, the mortality differences between white and black TNBC patients were mainly influenced by these factors. However, the mortality differences between Hispanic and Asian patients compared to white patients were largely unaffected by these factors.
Article
Surgery
Neha Goel, Sina Yadegarynia, Maya Lubarsky, Seraphina Choi, Kristin Kelly, Raymond Balise, Susan B. Kesmodel, Erin Kobetz
Summary: This comprehensive analysis of breast cancer outcomes among Hispanic patients found that Hispanic Blacks have worse overall survival compared to Hispanic Whites, indicating that race/ethnicity is a complex variable influenced by biological, social, and structural factors. Black race was identified as a marker of vulnerability, while Hispanic ethnicity was a marker of resilience, aiming to address the persistent survival gap in breast cancer.
Article
Medicine, General & Internal
Maria Clara Pascual, Juan Jose Montano, Paula Franch, Carmen Sanchez-Contador, Maria Ramos
Summary: This study aims to determine the cause-specific survival and prognostic factors of breast cancer in Mallorca, Spain. The study found that age, cancer stage, and molecular classification are important factors influencing the prognosis of breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dahai Yu, Zheng Wang, Yamei Cai, Kate McBride, Uchechukwu Levi Osuagwu, Karen Pickering, John Baker, Richard Cutfield, Brandon J. Orr-Walker, Gerhard Sundborn, Michael B. Jameson, Zhanzheng Zhao, David Simmons
Summary: This study compared the risks of 21 common cancers among Maori, Pasifika, and New Zealand European individuals with type 2 diabetes in New Zealand from 1994 to 2018. Significant differences in cancer risks were found among different ethnic groups.
Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Sarah J. Nyante, Linn Abraham, Erin J. Aiello Bowles, Christoph Lee, Karla Kerlikowske, Diana L. Miglioretti, Brian L. Sprague, Louise M. Henderson
Summary: This study evaluated the differences in diagnostic mammography performance among women of different race/ethnicities. The results showed that invasive cancer detection rate and positive predictive value were highest among non-Hispanic White women and lowest among Hispanic women. Additionally, short interval follow-up recommendations were most common among non-Hispanic Black women, while false-positive biopsy recommendations were most common among Asian/Pacific Islander women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Robert B. Hines, Xiang Zhu, Eunkyung Lee, Carolyn D. Rapp, Albert M. Volk, Asal M. Johnson
Summary: This study used multiple mediation analysis to identify the most important mediators of the racial disparity in breast cancer survival. The results suggest that increasing uptake of screening mammography and access to and receipt of surgery may offer the greatest potential to reduce racial disparities in breast cancer survival.
CANCER EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Mark J. McKeage, Sandar Tin Tin, Prashannata Khwaounjoo, Karen Sheath, Amanda Dixon-McIver, Daniel Ng, Richard Sullivan, Laird Cameron, Philip Shepherd, George R. Laking, Nicola Kingston, Magreet Strauss, Christopher Lewis, Mark Elwood, Donald R. Love
INTERNAL MEDICINE JOURNAL
(2020)
Article
Obstetrics & Gynecology
Susan M. Bigby, Sandar Tin Tin, Lois J. Eva, Phillipa Shirley, Kieran Dempster-Rivett, Mark Elwood
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2020)
Article
Behavioral Sciences
Khin San San Kyaw, Sandar Tin Tin, Lisa Underwood, Cameron Grant
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2020)
Article
Oncology
Sandar Tin Tin, Gillian K. Reeves, Timothy J. Key
INTERNATIONAL JOURNAL OF CANCER
(2020)
Review
Oncology
Aye Myat Thi, Sandar Tin Tin, Mark McKeage, J. Mark Elwood
Article
Oncology
Phyu Sin Aye, Sandar Tin Tin, Mark James McKeage, Prashannata Khwaounjoo, Alana Cavadino, J. Mark Elwood
Article
Oncology
Phyu Sin Aye, Mark James McKeage, Sandar Tin Tin, Prashannata Khwaounjoo, J. Mark Elwood
CANCER EPIDEMIOLOGY
(2020)
Article
Environmental Sciences
Mohammad Shoaib Abrahimi, Mark Elwood, Ross Lawrenson, Ian Campbell, Sandar Tin Tin
Summary: This study investigated the type of loco-regional treatment and associated factors in New Zealand women with early-stage breast cancer eligible for breast conserving surgery. Results showed variations in the receipt of BCS+RT across demographic and clinical factors, with higher breast cancer-specific mortality risk for women receiving MTX alone compared to BCS+RT. Further research is needed to explore the potential advantages of BCS+RT over alternative treatments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Sandar Tin Tin, Gillian K. Reeves, Timothy J. Key
Summary: This study conducted using UK Biobank data identified associations between breast cancer risk and concentrations of testosterone, IGF-1, and SHBG, with heterogeneity by menopausal status for testosterone.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Cody Z. Watling, Rebecca K. Kelly, Tammy Y. N. Tong, Carmen Piernas, Eleanor L. Watts, Sandar Tin Tin, Anika Knuppel, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: The study found that circulating IGF-I concentrations were positively associated with intake of total protein, milk protein, and yogurt protein, but not with cheese protein. Additionally, fibre and starch from wholegrains were positively associated with IGF-I concentrations, while alcohol intake was inversely associated.
CLINICAL NUTRITION
(2021)
Article
Pediatrics
Yan Myo Aung, Tim Jelleyman, Shanthi Ameratunga, Sandar Tin Tin
Summary: This study investigated the association between BMI and early childhood caries (ECC) among pre-school children in New Zealand. The results showed that ECC was highly prevalent in New Zealand children and associated with higher BMI in children of European ethnicity.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Article
Multidisciplinary Sciences
Phyu Sin Aye, Mark James McKeage, Sandar Tin Tin, Prashannata Khwaounjoo, J. Mark Elwood
Summary: This study aimed to estimate the population-based incidence rates of EGFR mutation-positive and EGFR mutation-negative non-squamous NSCLC in different population groups in northern New Zealand. The results showed that the population risk of EGFR mutation-positive NSCLC was significantly higher for Maori and Pacifica compared with New Zealand Europeans.
Article
Oncology
Eleanor L. Watts, Aurora Perez-Cornago, Aiden Doherty, Naomi E. Allen, Georgina K. Fensom, Sandar Tin Tin, Timothy J. Key, Ruth C. Travis
Summary: The study found modest associations between physical activity and hormones, with the relationships largely attenuated after adjustment for BMI, suggesting that changes in these circulating hormones are unlikely to explain the associations of physical activity with cancer risk independently or via BMI.
CANCER CAUSES & CONTROL
(2021)
Review
Biochemistry & Molecular Biology
Hung-Jin Huang, Chu-Lin Chou, Tin Tin Sandar, Wen-Chih Liu, Hsiu-Chien Yang, Yen-Chung Lin, Cai-Mei Zheng, Hui-Wen Chiu
Summary: Kidney diseases, such as CKD and AKI, are prevalent worldwide and have increased in recent decades. New diagnostic and predictive biomarkers have been discovered to better understand renal dysfunction and assess clinical risk. Animal studies are commonly used to identify specific biomarkers, but alternative methods have been developed to avoid unethical animal usage.
Meeting Abstract
Public, Environmental & Occupational Health
S. Tin Tin, G. K. Reeves, T. J. Key
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2020)