Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial
Authors
Keywords
Colorectal cancer, Niclosamide, S100A4
Journal
BMC CANCER
Volume 18, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-03-15
DOI
10.1186/s12885-018-4197-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma
- (2016) K. Satoh et al. CLINICAL CANCER RESEARCH
- The Anthelmintic Drug Niclosamide Inhibits the Proliferative Activity of Human Osteosarcoma Cells by Targeting Multiple Signal Pathways
- (2015) Zhan Liao et al. CURRENT CANCER DRUG TARGETS
- RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis
- (2015) Mathias Dahlmann et al. Oncotarget
- Intervening in β-Catenin Signaling by Sulindac Inhibits S100A4-Dependent Colon Cancer Metastasis
- (2015) Ulrike Stein et al. NEOPLASIA
- Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
- (2014) E. Van Cutsem et al. ANNALS OF ONCOLOGY
- Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
- (2014) Yonghe Li et al. CANCER LETTERS
- Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
- (2014) Masanori Ono et al. FERTILITY AND STERILITY
- Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer
- (2014) Rebecca C. Arend et al. GYNECOLOGIC ONCOLOGY
- Overexpression of S100A4 as a biomarker of metastasis and recurrence in oral squamous cell carcinoma
- (2014) Jayalakshmi NATARAJAN et al. Journal of Applied Oral Science
- Effect of Niclosamide on Basal-like Breast Cancers
- (2014) A. I. Londono-Joshi et al. MOLECULAR CANCER THERAPEUTICS
- WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer
- (2014) M L King et al. ONCOGENE
- Anticancer Effects of Niclosamide in Human Glioblastoma
- (2013) A. Wieland et al. CLINICAL CANCER RESEARCH
- Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
- (2013) J. Ferlay et al. EUROPEAN JOURNAL OF CANCER
- Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity
- (2013) Min Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non-Small Cell Lung Cancer
- (2013) R. Li et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of STAT3 by Niclosamide Synergizes with Erlotinib against Head and Neck Cancer
- (2013) Rui Li et al. PLoS One
- Niclosamide suppresses hepatoma cell proliferation via the Wnt pathway
- (2013) Minoru Tomizawa et al. OncoTargets and Therapy
- ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
- (2012) H. J. Schmoll et al. ANNALS OF ONCOLOGY
- Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer
- (2012) Ane Kongsgaard Rud et al. BMC CANCER
- EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer
- (2012) K Boye et al. BRITISH JOURNAL OF CANCER
- Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
- (2012) Bruno D. Fonseca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen
- (2012) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
- (2012) Axel Grothey et al. LANCET
- Growth Inhibition of Ovarian Tumor-Initiating Cells by Niclosamide
- (2012) Y.-T. Yo et al. MOLECULAR CANCER THERAPEUTICS
- Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells
- (2012) Jing-Xuan Pan et al. Chinese Journal of Cancer
- Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations
- (2011) T. Osada et al. CANCER RESEARCH
- Diagnostic and Prognostic Value of Metastasis Inducer S100A4 Transcripts in Plasma of Colon, Rectal, and Gastric Cancer Patients
- (2011) Ulrike Stein et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer
- (2011) U. Sack et al. JNCI-Journal of the National Cancer Institute
- S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells
- (2011) Ulrike Sack et al. MOLECULAR BIOLOGY OF THE CELL
- Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway
- (2011) Wenyan Lu et al. PLoS One
- Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production
- (2011) F L Khanim et al. Blood Cancer Journal
- Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach
- (2010) Wei Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF- B Pathway and Generation of Reactive Oxygen Species
- (2010) Y. Jin et al. CANCER RESEARCH
- Nuclear S100A4 is a novel prognostic marker in colorectal cancer
- (2010) Kjetil Boye et al. EUROPEAN JOURNAL OF CANCER
- Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- (2010) Xiaomei Ren et al. ACS Medicinal Chemistry Letters
- S100A4 and Metastasis
- (2009) Kjetil Boye et al. AMERICAN JOURNAL OF PATHOLOGY
- The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
- (2009) Minyong Chen et al. BIOCHEMISTRY
- Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling
- (2009) Aruna D. Balgi et al. PLoS One
- S100A4: a common mediator of epithelial–mesenchymal transition, fibrosis and regeneration in diseases?
- (2008) Mikael Schneider et al. JOURNAL OF MOLECULAR MEDICINE-JMM
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started