Article
Oncology
Hannah C. Timmins, Tiffany Li, Terry Trinh, Matthew C. Kiernan, Michelle Harrison, Frances Boyle, Michael Friedlander, David Goldstein, Susanna B. Park
Summary: The study reveals that weekly paclitaxel treatment can induce neuropathy early on and patients may require closer monitoring. Dose reduction does not necessarily result in better neuropathy outcomes, with individual risk factors also playing a significant role.
Article
Oncology
Huy Phuoc Quang Nguyen, Woo Kyun Bae, Myong Suk Park, Ik-Joo Chung, Taek-Keun Nam, Jae-Uk Jeong, Tung Nguyen Thanh Uong, Duck Cho, Sang-Ki Kim, Meesun Yoon
Summary: This study aims to investigate the efficacy of adoptive natural killer (NK) cell immunotherapy in combination with chemoradiotherapy for colorectal cancer (CRC). The results demonstrate that the combination of low-dose chemoradiotherapy and NK cell therapy can significantly enhance primary tumor control and improve survival outcomes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Xuelei Chu, Peng Xue, Shijie Zhu
Summary: Chemotherapy dose intensity is a significant parameter in antitumor clinical medication, affecting treatment efficacy, disease prognosis, and patient safety.
Article
Medicine, General & Internal
Shu hui Peng, Hussein Said Mbarak, Yan-Hui Li, Cong Ma, Quan-Liang Shang, Zhu Chen, Du-Jun Bian, En-Hua Xiao
Summary: Preoperative transcatheter arterial infusion chemotherapy is a safe and effective neoadjuvant chemotherapy measure for CRC, with fewer adverse reactions and a higher overall disease control rate compared to intravenous chemotherapy.
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Article
Oncology
Daniel Boakye, Lina Jansen, Niels Halama, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner
Summary: Chemotherapy benefits for stage III colon cancer patients depend on completion of treatment, with over half of early discontinuation and dose reduction cases attributed to adverse treatment effects.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Diana Duarte, Nuno Vale
Summary: Drug repurposing and drug combination have emerged as alternatives to costly and ineffective de novo drug development. These strategies offer benefits of lower cost, quicker development, and ease of application, while also enabling increased efficacy, reduced toxicity, and overcoming drug resistance. The potential for combining repurposed drugs in cancer therapy, particularly for colorectal cancer, remains an under-explored area in pre-clinical and clinical development.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Preksha Vinchhi, Mayur M. Patel
Summary: Employing nanotechnology-based approaches has shown promising outcomes in the prevention, diagnosis, and treatment of CRC. These approaches can overcome the major drawbacks of traditional diagnostic and therapeutic methods, allowing for early detection and efficient therapy. Nanocarriers offer controlled drug release, improved bioavailability, enhanced tumor targetability, and reduced adverse effects in the treatment of CRC.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Sonia Chauhan, Devinder K. Dhawan, Avneet Saini, Simran Preet
Summary: Despite recent progress in colorectal cancer treatment, low survival rates and chemotherapy side effects remain a global concern. Antimicrobial peptides show promise as a novel treatment option, with potential modifications to enhance their effectiveness. Further research is needed to explore their use in CRC therapy, either alone or in combination with existing treatments.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Philip B. Paty, Julio Garcia-Aguilar
Summary: Although surgery has been the mainstay for treating colorectal cancer, advances in technology and clinical trials over the past 50 years have significantly expanded and improved the detection, staging, treatment, and understanding of this disease. This review highlights the contributions of surgeons, oncologists, gastroenterologists, engineers, and scientists in enhancing postsurgical survival, reducing treatment time and toxicity, and improving patients' quality of life over the past half-century.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hung Ho-Xuan, Gerhard Lehmann, Petar Glazar, Foivos Gypas, Norbert Eichner, Kevin Heizler, Hans J. Schlitt, Mihaela Zavolan, Nikolaus Rajewsky, Gunter Meister, Christina Hackl
Summary: Colorectal cancer is a common cancer type with a high mortality rate, and chemotherapy often leads to chemo-resistance and tumor relapse. Low dose metronomic (LDM) therapy is a novel chemotherapeutic approach that may offer new potential therapeutic targets.
Article
Oncology
Vicenc Ruiz de Porras, Laura Layos, Eva Martinez-Balibrea
Summary: Colorectal cancer is the second leading cause of cancer death globally, and is mainly treated with combinations of cytotoxic chemotherapy plus anti-EGFR or anti-VEGF drugs. Curcumin, a natural product with proven anticancer properties and low toxicity, is being studied as a potential treatment for CRC. Despite its poor bioavailability, new formulations are showing promising results in increasing its effectiveness in clinical settings.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Yvonne M. Geurts, Rebecca Shakir, Georgios Ntentas, Sander Roberti, Marianne C. Aznar, Katinka M. John, Johanna Ramroth, Cecile P. M. Janus, Augustinus D. G. Krol, Judith M. Roesink, Richard W. M. van der Maazen, Josee M. Zijlstra, Sarah C. Darby, Berthe M. P. Aleman, Flora E. van Leeuwen, David J. Cutter, Michael Schaapveld
Summary: This study found a dose-response association between radiation therapy and colorectal cancer risk in Hodgkin lymphoma survivors. The risk of colorectal cancer increased for patients who received subdiaphragmatic radiation therapy and high-dose procarbazine treatment. These findings can contribute to individualized colorectal cancer risk estimations, identification of high-risk survivors for subsequent screening, and optimization of treatment strategies.
Article
Oncology
Giuseppe Antonio Colloca, Antonella Venturino, Domenico Guarneri
Summary: Through analyzing derived neutrophil-to-lymphocyte ratio and reduction > 10% after the first cycle of chemotherapy in mCRC patients, it was found that this ratio change can predict overall survival and disease control in second-line chemotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Michael J. Raphael, Paul J. Karanicolas
Summary: Regional therapies, such as hepatic arterial infusion pump chemotherapy and drug-eluting beads, are effective treatment options for patients with unresectable colorectal liver metastases. These therapies allow selective delivery of drugs to tumors while sparing normal liver tissue. However, there is a lack of randomized controlled trial evidence to guide the optimal integration of regional therapies into the management of colorectal liver metastases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Xiao F. He, Yue Y. Xiao, Xiao Zhang, Xiao B. Zhang, Xin Zhang, Ying T. Wei, Zhong L. Zhang, Philipp Wiggermann
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hinrich Winther, Christian Hundt, Kristina Imeen Ringe, Frank K. Wacker, Bertil Schmidt, Julian Juergens, Michael Haimerl, Lukas Philipp Beyer, Christian Stroszczynski, Philipp Wiggermann, Niklas Verloh
Summary: This study introduces a fully automated liver segmentation tool for Gd-EOB-DTPA-enhanced MRI scans using deep learning, achieving competitive results compared to expert manual segmentation and completing the task in a short amount of time.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2021)
Article
Hematology
Ernst Michael Jung, Martin Engel, Philipp Wiggermann, Andreas Schicho, Markus Lerchbaumer, Christian Stroszczynski, Thomas Fischer, Isabel Wiesinger
Summary: This study aimed to evaluate the efficacy of irreversible electroporation (IRE) in prostate cancer and distinguish between reactive changes and tumors. The results showed a high success rate of IRE treatment and the potential of contrast-enhanced ultrasound (CEUS) and parametric imaging in detecting residual tumors, with a sensitivity of 76% and a specificity of 81%.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Urology & Nephrology
Daniela Kopp, Johannes Kopp, Eugen Bernhardt, Lukas Manka, Andreas Beck, Holger Gerullis, Pierre I. Karakiewicz, Georg Salomon, Philipp Wiggermann, Peter Hammerer, Jonas Schiffmann
Summary: This study evaluated the use of PSMA PET/CT in primary staging of D'Amico intermediate-risk PCa patients, showing high specificity and NPV rates but lower sensitivity and PPV rates. Larger prospective trials are needed to confirm these results and address potential biases in smaller studies.
UROLOGIA INTERNATIONALIS
(2022)
Article
Oncology
Wolf Baeumler, Philipp Wiggermann, Lukas Luerken, Marco Dollinger, Christian Stroszczynski, Lukas P. Beyer, Andreas Schicho
Summary: The study investigated local tumor progression after IRE treatment of HCC and found MR imaging features helpful in identifying re-grown viable tumors. LTP was mainly detected in the peripheral ablation zone, with T2 BLADE and diffusion sequences aiding detection in the peripheral zone, while T1 p.v. and T1 d.p. showed the highest sensitivity in the central zone.
Article
Hematology
Carolina Rio Bartulos, Dennis Lier, Harald Sahl, Mazen Abu-Mugheisib, Annette Spreer, Philipp Wiggermann
Summary: This retrospective study analyzed data from 133 patients who underwent mechanical thrombectomy, finding correlations between NIHSS score and TICI score with different time points. The study provides valuable data from daily clinical practice for stroke management.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Hematology
Karin Senk, Juliane Wilcke, Michael Haimerl, Niklas Verloh, Carolina Rio Bartulos, Wolf Baeumler, Christian Stroszczynski, Philipp Wiggermann
Summary: The LiMAx test showed better correlation with the outcome of TACE treatment compared to the MELD score in predicting patient responses. Patients with higher pre-interventional LiMAx values tended to have better treatment outcomes with TACE.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Engineering, Biomedical
Helena Cindric, Panchatcharam Mariappan, Lukas Beyer, Philipp Wiggermann, Michael Moche, Damijan Miklavcic, Bor Kos
Summary: This study aimed to determine the electric field threshold that best fits the local response to irreversible electroporation (IRE) ablation of hepatic tumors, evaluate the heat generating effect of IRE numerically, and demonstrate the utility of treatment planning for future improvements. Results indicated that lesions visible on MRI 6 weeks post IRE correspond to areas experiencing an electric field of 900 V/cm or higher, with the study suggesting that the 6-week follow-up period may have been too long, leading to overestimation of the threshold. The study's sophisticated method for validating the numerical treatment planning framework can inform the design of future prospective studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Niklas Verloh, Irene Fuhrmann, Claudia Fellner, Dominik Nickel, Florian Zeman, Arne Kandulski, Matthias Hornung, Christian Stroszczynski, Philipp Wiggermann, Michael Haimerl
Summary: This study compares two different T1 relaxometry techniques for evaluating liver function using C-13-AMT as the standard. The results show that the Look-Locker sequence is less susceptible to artifacts and may be more suitable for patients with impaired liver function.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Medicine, General & Internal
Carolina Rio Bartulos, Karin Senk, Mona Schumacher, Jan Plath, Nico Kaiser, Ragnar Bade, Jan Woetzel, Philipp Wiggermann
Summary: This article discusses the technique of dynamic assessment of liver function based on MRI, pointing out the advantages and application prospects of this technology, and summarizing relevant research results.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Wolf Baeumler, Lukas Philipp Beyer, Lukas Luerken, Philipp Wiggermann, Christian Stroszczynski, Marco Dollinger, Andreas Schicho
Summary: Measurement of iodine uptake may aid in identifying local tumor progression (LTP) after IRE and MWA treatment of HCC.
Article
Medicine, General & Internal
Carolina Rio Bartulos, Karin Senk, Ragnar Bade, Mona Schumacher, Jan Plath, Nico Kaiser, Isabel Wiesinger, Sylvia Thurn, Christian Stroszczynski, Abdelouahed El Mountassir, Mathis Planert, Jan Woetzel, Philipp Wiggermann
Summary: In the management of patients with chronic liver disease, the assessment of liver function is crucial for treatment planning. This study demonstrated and evaluated the diagnostic performance of two fully automatically generated liver function scores that consider the entire liver. The results showed that it is feasible to determine total liver function and regionally resolve it using MR liver imaging, providing the opportunity to use the MELIF score as a diagnostic marker in future prospective studies.
Article
Cardiac & Cardiovascular Systems
Tze Min Wah, Maciej Pech, Maximilian Thormann, Xavier Serres, Peter Littler, Benjamin Stenberg, James Lenton, Jonathan Smith, Philipp Wiggermann, Mathis Planert, Joan Vidal-Jove, Guido Torzilli, Luigi Solbiati
Summary: This study aims to assess the safety and efficacy of image-guided histotripsy in the treatment of primary and metastatic liver cancers. By destroying targeted tissue under ultrasound visualization through the precise application of acoustic cavitation, this non-invasive, non-thermal, and non-ionizing radiation treatment technology has the potential to serve as a new option.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Correction
Oncology
Niklas Verloh, Isabel Jensch, Lukas Luerken, Michael Haimerl, Marco Dollinger, Philipp Renner, Philipp Wiggermann, Jens Martin Werner, Florian Zeman, Christian Stroszczynski, Lukas Philipp Beyer
RADIOLOGY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jan Schaible, Lukas Luerken, Philipp Wiggermann, Niklas Verloh, Ingo Einspieler, Florian Zeman, Andreas G. Schreyer, Reto Bale, Christian Stroszczynski, Lukas Beyer
SCIENTIFIC REPORTS
(2020)
