Successful production of genome-edited rats by the rGONAD method

Application of genome editing technologies in rats for human disease models

(2017) Kazuto Yoshimi et al.   JOURNAL OF HUMAN GENETICS

From engineering to editing the rat genome

(2017) Stephen Meek et al.   MAMMALIAN GENOME

Renal disease pathophysiology and treatment: contributions from the rat

(2016) Linda J. Mullins et al.   Disease Models & Mechanisms

CRISPR: a versatile tool for both forward and reverse genetics research

(2016) Channabasavaiah B. Gurumurthy et al.   HUMAN GENETICS

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

(2016) Kazuto Yoshimi et al.   Nature Communications

GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice

(2015) Gou Takahashi et al.   Scientific Reports

Simple Genome Editing of Rodent Intact Embryos by Electroporation

(2015) Takehito Kaneko et al.   PLoS One

Secreted Frizzled-related Protein 1 (Sfrp1) Regulates the Progression of Renal Fibrosis in a Mouse Model of Obstructive Nephropathy

(2014) Makoto Matsuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Balancing the welfare: the use of non-human primates in research

(2014) Qi Zhou   TRENDS IN GENETICS

Simple knockout by electroporation of engineered endonucleases into intact rat embryos

(2014) Takehito Kaneko et al.   Scientific Reports

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat

(2013) Santosh S. Atanur et al.   CELL

Heritable gene-targeting with gRNA/Cas9 in rats

(2013) Xinli Hu et al.   CELL RESEARCH

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems

(2013) Wei Li et al.   NATURE BIOTECHNOLOGY

Heritable gene targeting in the mouse and rat using a CRISPR-Cas system

(2013) Dali Li et al.   NATURE BIOTECHNOLOGY

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

(2010) Chang Tong et al.   NATURE

Targeted integration in rat and mouse embryos with zinc-finger nucleases

(2010) Xiaoxia Cui et al.   NATURE BIOTECHNOLOGY

Glomerular diseases: genetic causes and future therapeutics

(2010) Chih-Kang Chiang et al.   Nature Reviews Nephrology

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE