Article
Obstetrics & Gynecology
M. C. Rulanda, O. Mogensen, P. T. Jensen, D. G. Hansen, C. Wu, M. M. Jeppesen
Summary: This study compares the effects of patient initiated follow up (PIFU) versus hospital based follow up (HBFU) on fear of cancer recurrence (FCR), quality of life (QoL), and healthcare use after 34 months of follow up. The results indicate that patient initiated follow up is a valid alternative to hospital based follow up for low-intermediate risk endometrial carcinoma patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Anja Schmidt Vejlgaard, Sanne Rasmussen, Peter Fentz Haastrup, Dorte Ejg Jarbol, Kirubakaran Balasubramaniam
Summary: Concern for gynaecological alarm symptoms and current health was positively associated with healthcare-seeking behavior among women with gynaecological alarm symptoms, indicating the importance of addressing concerns in promoting timely healthcare-seeking.
Review
Oncology
Jack Horan, Conor Reid, Michael R. Boland, Gordon R. Daly, Stephen Keelan, Angus J. Lloyd, Eithne Downey, Adam Walmsley, Marie Staunton, Colm Power, Abeeda Butt, Deirdre Duke, Arnold D. K. Hill
Summary: This study evaluated diagnostic modalities for recurrent breast cancer, with a focus on the role of annual clinical examination. The results showed that clinical examination provides little value in diagnosing recurrence, suggesting that surveillance programs should reduce focus on this modality and instead prioritize regular radiological assessment and ensuring easy access to breast clinics for patients with new symptoms/signs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kazuto Nakamura, Yoshikazu Kitahara, Soichi Yamashita, Keiko Kigure, Ikuro Ito, Toshio Nishimura, Anri Azuma, Tatsuya Kanuma
Summary: In this retrospective study, an intensive surveillance protocol did not benefit patients with endometrial cancer. Thus, it is hypothesized that characterizing tumors using emerging technologies to precisely predict tumor nature will help tailor individualized and efficient surveillance programs. Furthermore, the development of ideal salvage therapy is needed to benefit patients after recurrence.
Article
Oncology
Hiu Mei Luk, Siew Fei Ngu, Lesley S. K. Lau, Ka Yu Tse, Mandy M. Y. Chu, Shuk Tak Kwok, Hextan Y. S. Ngan, Karen K. L. Chan
Summary: This study assessed the feasibility of patient-initiated follow-up (PIFU) combined with regular tumour marker monitoring as an alternative to conventional hospital follow-up for ovarian cancer survivors. The results showed that PIFU with tumour marker monitoring is a feasible approach in ovarian cancer survivorship care, with comparable fear of cancer recurrence (FCR) and supportive care need (SCN) to conventional hospital follow-up.
Article
Oncology
A. Collins, A. Taylor, D. S. Guttery, E. L. Moss
Summary: This review article outlines the evidence base for alternative follow-up strategies in different risk categories of endometrial cancer, as well as future directions such as emerging new techniques like liquid biopsy and opportunities for personalizing follow-up based on molecular and clinicopathological features.
Article
Surgery
Michael J. Pflueger, James F. Griffin, Wenzel M. Hackeng, Satomi Kawamoto, Jun Yu, Peter Chianchiano, Eunice Shin, Gemma Lionheart, Hua-Ling Tsai, Hao Wang, Neda Rezaee, Richard A. Burkhart, John L. Cameron, Elizabeth D. Thompson, Christopher L. Wolfgang, Jin He, Lodewijk A. A. Brosens, Laura D. Wood
Summary: This study aimed to identify risk factors for recurrence after surgical resection for intraductal papillary mucinous neoplasm (IPMN). The results showed that family history of pancreatic cancer and high-grade IPMN are risk factors for recurrence. In addition, the size and grade of the dysplastic focus at the margin were significantly correlated with recurrence in margin-positive patients. The majority of recurrences occurred after 3 years of surgery.
Article
Oncology
Virginie Westeel, Pascal Foucher, Arnaud Scherpereel, Jean Domas, Philippe Girard, Jean Tredaniel, Marie Wislez, Patrick Dumont, Elisabeth Quoix, Olivier Raffy, Denis Braun, Marc Derollez, Francois Goupil, Jacques Hermann, Etienne Devin, Hubert Barbieux, Eric Pichon, Didier Debieuvre, Gervais Ozenne, Jean-Francois Muir, Stephanie Dehette, Jerome Virally, Michel Grivaux, Francois Lebargy, Pierre-Jean Souquet, Faraj Al Freijat, Nicolas Girard, Emmanuel Courau, Reza Azarian, Michel Farny, Jean-Paul Duhamel, Alexandra Langlais, Franck Morin, Bernard Milleron, Gerard Zalcman, Fabrice Barlesi
Summary: This study evaluates the efficacy of postoperative follow-up methods for patients with resectable NSCLC. The results show that there is no significant difference in survival and disease-free survival between the follow-up group and the minimal follow-up group in the intention-to-treat population. However, CT-based follow-up enables earlier detection of recurrence and second primary lung cancer, which can be treated with curative intent.
Article
Oncology
Anna Relton, Anna Collins, David S. Guttery, Diviya N. Gorsia, Hilary J. McDermott, Esther L. Moss
Summary: The study suggests that many patients find ctDNA blood testing more acceptable for monitoring endometrial cancer recurrence than traditional clinical examinations. Despite potential anxiety, they prefer to be informed of results, even for small recurrences.
EUROPEAN JOURNAL OF CANCER CARE
(2021)
Article
Oncology
Paolo Zola, Giovannino Ciccone, Elisa Piovano, Luca Fuso, Daniela Di Cuonzo, Anna Castiglione, Eva Pagano, Elena Peirano, Fabio Landoni, Enrico Sartori, Fabrice Narducci, Oscar Bertetto, Annamaria Ferrero
Summary: The TOTEM study conducted a randomized trial on intensive versus minimalist follow-up regimens in endometrial cancer-treated patients. The study found that intensive follow-up did not improve overall survival rates, even in high-risk patients. Routine addition of vaginal cytology, laboratory, or imaging investigations is unnecessary according to the results of this trial.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Chad A. Hamilton, Bhavana Pothuri, Rebecca C. Arend, Floor J. Backes, Paola A. Gehrig, Pamela T. Soliman, J. Spencer Thompson, Renata R. Urban, William M. Burke
Summary: Since 2014, there have been significant advancements in the treatment of endometrial cancer, however, the incidence and deaths related to the disease have continued to rise. This document provides a comprehensive review of these advancements.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Racheal Louise Johnson, Cheng Choy
Summary: Patient-initiated follow-up post-surgical treatment of early endometrial cancer is safe, holistic for cardiovascular health improvement, and cost-effective. The exercise course helps patients in weight loss, happiness, confidence, and stress management, leading to high recommendation rates among peers.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Oncology
Jeongseok Jeon, Da Bin Lee, Sang Joon Shin, Dai Hoon Han, Jee Suk Chang, Yoon Dae Han, Hyunwook Kim, Joon Seok Lim, Han Sang Kim, Joong Bae Ahn
Summary: This study found that high-frequency abdominopelvic computed tomography (AP-CT) testing is associated with a higher proportion of surgery plus chemo- or radiotherapy as postrecurrence treatment, but does not improve the 5-year overall survival rate of patients with stage II-III colon cancer.
CLINICAL COLORECTAL CANCER
(2023)
Article
Surgery
Sin Hye Park, Woo Jin Hyung, Han-Kwang Yang, Young-Kyu Park, Hyuk-Joon Lee, Ji Yeong An, Wook Kim, Hyoung-Il Kim, Hyung-Ho Kim, Seung Wan Ryu, Hoon Hur, Min-Chan Kim, Seong-Ho Kong, Gyu Seok Cho, Jin-Jo Kim, Do Joong Park, Young-Woo Kim, Jong Won Kim, Joo-Ho Lee, Sang-Uk Han, Keun Won Ryu
Summary: The study did not find any survival benefit from regular follow-up after radical gastrectomy for gastric cancer, and it suggests the need for a prospective randomized controlled trial to determine the survival benefit.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Jean-Christophe Leclere, Camille Clement, Romain Le Pennec, Clementine Maheo, Dorothy M. Gujral, Ulrike Schick, Gregoire Le Gal, Remi Marianowski, Pierre-Yves Salaun, Ronan Abgral
Summary: In this case-control study, the use of (18)FDG-PET/CT in the standard annual follow-up of HNSCC was associated with a 3-year survival benefit, with a larger benefit for patients with advanced initial tumor stage (III-IV) and oropharyngeal disease.
Article
Oncology
Sara Elisabeth Sponholtz, Nicole P. M. Ezendam, Belle H. de Rooij, Erik Parner, Ole Mogensen, Malene Grubbe Hildebrandt, Doris Schledermann, Algirdas Markauskas, Ligita Paskeviciute Froding, Katrine Fuglsang, Sarah Marie Bjornholt, Pernille Tine Jensen
Summary: This study evaluates the occurrence and severity of early lymphedema, as well as its impact on quality of life, in women undergoing surgery for early-stage cervical cancer. The results show that sentinel lymph node (SLN) mapping alone carries a low risk of lymphedema, while completion pelvic lymphadenectomy (PL) is associated with a high incidence of early lymphedema. Reporting lymphedema is significantly associated with impairment in various aspects of physical, psychological, and social functioning.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Obstetrics & Gynecology
Dina Overgaard Eriksen, Pernille Tine Jensen, Jeppe Bennekou Schroll, Anne Hammer
Summary: This review and meta-analysis aimed to investigate the association between human papilloma virus (HPV) vaccination administered after excisional treatment of cervical intraepithelial neoplasia (CIN) and the risk of CIN grade 2 or worse (CIN2+) recurrence. The analysis included nine studies and found that post-treatment HPV vaccination was associated with a significantly reduced risk of CIN2+ recurrence. However, there were serious risks of bias in the included studies.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Psychology, Multidisciplinary
Nina Rottmann, Pia Veldt Larsen, Christoffer Johansen, Mariet Hagedoorn, Susanne Oksbjerg Dalton, Dorte Gilsa Hansen
Summary: Breast cancer has a profound impact on the sex life of couples. Patient-, partner-, and relationship-related characteristics are associated with sexual activity after breast cancer diagnosis. Couples with higher emotional closeness, affectionate behavior, and satisfaction with dyadic coping are more likely to engage in sexual activity.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Trine Allerslev Horsbol, Susanne K. Kjaer, Elisabeth Wreford Andersen, Gunn Ammitzboll, Lau Caspar Thygesen, Christoffer Johansen, Pernille Tine Jensen, Ligita Paskeviciute Froding, Henrik Lajer, Susanne Oksbjerg Dalton
Summary: This nationwide register-based cohort study found that women diagnosed with cervical cancer have an increased risk of using hypnotics, especially during the first year after diagnosis. Higher age, lower education, previous use of antidepressants or anxiolytics, and advanced disease were identified as risk factors for prolonged use of hypnotics.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Jorun Holm, Oke Gerke, Mie Holm Vilstrup, Diana Spasojevic, Sara Elisabeth Sponholtz, Kirsten Marie Jochumsen, Anders Thomassen, Malene Grubbe Hildebrandt, Pernille Tine Jensen
Summary: This study aimed to investigate the prognostic value of lymph node metastases identified by imaging in patients with carcinoma of the uterine cervix (CCU). The results showed that approximately one-third of CCU patients staged according to FIGO-2009 had suspected lymph node metastasis on imaging and were upstaged to stage IIIC according to FIGO-2018. The cancer-specific mortality was significantly lower in lymph node-negative patients in stages IBI-II, supporting the stage migration due to suspected lymph node metastasis within this group.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
W. L. Van der Kolk, A. G. J. Van der Zee, B. M. Slomovitz, P. J. W. Baldwin, H. C. Van Doorn, J. A. De Hullu, J. Van der Velden, K. N. Gaarenstroom, B. F. M. Slangen, P. Kjolhede, M. Brannstrom, I Vergote, C. M. Holland, R. Coleman, E. B. L. Van Dorst, W. J. Van Driel, D. Nunns, M. Widschwendter, D. Nugent, P. A. DiSilvestro, R. S. Mannel, M. Y. Tjiong, D. Boll, D. Cibula, A. Covens, D. Provencher, I. B. Runnebaum, B. J. Monk, V Zanagnolo, K. Tamussino, M. H. M. Oonk, C. F. Levenback, R. H. Hermans, J. Bouda, A. Sharma, D. Luesley, P. Ellis, D. J. Cruickshank, T. J. Duncan, K. Kieser, C. Palle, N. M. Spirtos, D. M. O'Malley, M. M. Leitao, M. Geller, K. Dhar, V Asher, D. H. Tobias, C. Borgfeldt, J. S. Lea, M. Lood, J. Bailey, B. Eyjolfsdottir, S. Attard-Montalto, K. S. Tewari, P. Persson, R. Manchanda, P. Jensen, L. Van Le
Summary: This study analyzed patients with early-stage vulvar squamous cell carcinoma and a metastatic unilateral inguinal sentinel lymph node to determine whether treatment of the contralateral groin can be safely omitted.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Karina Dahl Steffensen, Dorte Gilsa Hansen, Kurt Espersen, Susanne Lauth, Peter Fosgrau, Anders Meinert Pedersen, Peter Sigerseth Groen, Christian Sauvr, Karina Olling
Summary: This paper describes the development of a model called SDM:HOSP, which aims to achieve lasting shared decision making (SDM) between patients and healthcare professionals. Through four phases of development, including the development of conceptual elements, field testing, evaluation, and the development of the final model, SDM:HOSP can be easily adapted to different organizations and cultures.
Article
Medicine, Research & Experimental
Stinne Holm Bergholdt, Dorte Gilsaa Hansen, Anna Thit Johnsen, Bo Snedker Boman, Pernille Tine Jensen
Summary: This study aims to test a nurse-led, individualized, and need-based intervention with a specific focus on patient empowerment against a standard physician-led model primarily focusing on the detection of recurrence. The study will provide new information about follow-up in early-stage gynecological cancer settings and contribute to the improvement of future follow-up programs.
Article
Oncology
M. M. Jeppesen, S. H. Bergholdt, A. G. Bentzen, B. H. de Rooij, M. Skorstad, N. P. M. Ezendam, L. V. van de Poll-Franse, I. Vistad, P. T. Jensen
Summary: This study assessed healthcare utilization among female cancer survivors with endometrial, cervical, and ovarian cancer in the Netherlands, Norway, and Denmark. It found that cancer worry was associated with increased use of supportive care services.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Obstetrics & Gynecology
M. C. Rulanda, O. Mogensen, P. T. Jensen, D. G. Hansen, C. Wu, M. M. Jeppesen
Summary: This study compares the effects of patient initiated follow up (PIFU) versus hospital based follow up (HBFU) on fear of cancer recurrence (FCR), quality of life (QoL), and healthcare use after 34 months of follow up. The results indicate that patient initiated follow up is a valid alternative to hospital based follow up for low-intermediate risk endometrial carcinoma patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Hans H. B. Wenzel, Anna N. Hardie, Arturo Moncada-Torres, Claus K. Hogdall, Ruud L. M. Bekkers, Henrik Falconer, Pernille T. Jensen, Hans W. Nijman, Maaike A. van der Aa, Frank Martin, Anna J. van Gestel, Valery E. P. P. Lemmens, Pernilla Dahm-Kahler, Emilia Alfonzo, Jan Persson, Linnea Ekdahl, Sahar Salehi, Ligita P. Froding, Algirdas Markauskas, Katrine Fuglsang, Tine H. Schnack
Summary: By utilizing federated learning, researchers have developed a tool to identify a low-risk group of patients with presumed early-stage cervical cancer for lymph node dissection decision-making.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Sarah Marie Bjornholt, Sarah Elizabeth Sponholtz, Ole Mogensen, Kirsten Bouchelouche, Erik Thorlund Parner, Gudrun Neumann, Kirsten Marie Jochumsen, Bushra Hassan Hamid, Morten Billow Davidsen, Signe Frahm Bjorn, Katja Dahl, Pernille Tine Jensen
Summary: The SENTIREC-endo study investigates the risks and benefits of a national protocolled adoption of sentinel lymph node mapping in women with early-stage low-grade endometrial cancer. The study found that this technique is safe and can provide more accurate treatment allocation for patients in both low and intermediate risk groups.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Mille Guldager Christiansen, Helle Pappot, Pernille Tine Jensen, Mansoor Raza Mirza, Mary Jarden, Karin Piil
Summary: The objective of this study was to identify items appropriate for use in a PRO tool for women with endometrial or ovarian cancer undergoing treatment with taxanes in combination with carboplatin. A comprehensive literature search, patient advisory board discussions, and expert panel consultations were used to select 21 clinically relevant symptoms from the PRO-CTCAE library.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
