Journal
BIOTECHNOLOGY ADVANCES
Volume 36, Issue 3, Pages 557-576Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2017.12.016
Keywords
Virus; Inhibitor; Assay; High-throughput screening; Method; Replication; Entry; Assembly; In vitro; Cell-based
Categories
Funding
- GA CR (CZ) [GA17-25602S, GA17-24281S]
- Ministry of Education, Youth and Sport of the Czech Republic [OPPC CZ.2.16/3.1.00/24503, NPU LO 1601]
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Despite successful vaccination programs and effective treatments for some viral infections, humans are still losing the battle with viruses. Persisting human pandemics, emerging and re-emerging viruses, and evolution of drug-resistant strains impose continuous search for new antiviral drugs. A combination of detailed information about the molecular organization of viruses and progress in molecular biology and computer technologies has enabled rational antivirals design. Initial step in establishing efficacy of new antivirals is based on simple methods assessing inhibition of the intended target. We provide here an overview of biochemical and cell-based assays evaluating the activity of inhibitors of clinically important viruses.
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