Journal
BIOSENSORS & BIOELECTRONICS
Volume 100, Issue -, Pages 556-564Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.09.051
Keywords
Mercury; Attomolar; SERS; Fluorescence; Self-assembly; Sensor
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Funding
- JNCASR, Department of Biotechnology (DBT), India [BT/PR10263/NNT/28/711/2013]
- Department of science and technology (DST), India [DST/SJF/CSA-02/2015-16]
- Prof. CNR Rao Award
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The development of reliable and ultrasensitive detection marker for mercury ions (Hg2+) in drinking water is of great interest for toxicology assessment, environmental protection and human health. Although many Hg2+ detection methods have been developed, only few offer sensitivities below 1 pM. Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) as a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-gel transformation), fluorescence and SERS-based Hg(2+)sensor platform in the water. Remarkably, HPH as a SERS marker supported on Au deposited mono dispersed nanospheres monolayers (Au-MNM) of polystyrene offers an unprecedented selectivity and the best ever reported detection limit (LOD) of 60 attomolar (aM, 0.01 parts-per-quadrillion (ppq)) for Hg2+ in water. This is ten orders of magnitude lower than the United States Environmental Protection Agency (USEPA) tolerance limit of Hg2+ in drinking water (10 nM, 2 ppb). This simple and effective design principle of host-guest interactions driven fluorescence and SEAS-based detection may inspire the future molecular engineering strategies for the development of ultrasensitive toxic analyte sensor platforms.
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