Article
Materials Science, Multidisciplinary
Ravi Teja Mittireddi, Nisha Hiralal Makani, Deepak G. Prajapati, Abhay Raj Singh Gautam, Rupak Banerjee, Emila Panda
Summary: This study focuses on quantifying the impact of microstructure on the functionality of titanium dioxide films caused by minor changes in the fabrication process. Thin titanium dioxide films are deposited using sputtering with variations in target composition and working environment. Various characterization techniques are employed to quantitatively analyze the phase, chemical constitution, composition, thickness, roughness, density, etc. of the films and their link to electronic structure, electrical, optical, and surface characteristics. The insights from this study can guide the experimental design for fabricating films with desired functionalities by considering the tolerance range.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Physical
I Hotovy, L. Spiess, M. Mikolasek, I Kostic, M. Sojkova, H. Romanus, M. Hulman, D. Buc, V Rehacek
Summary: The study presents investigations on the structural, optical, and electrical properties of layered WS2 films synthesized on tungsten. The results show that the thickness of the W films and the sulfurization temperature affect the microstructure and electrical properties of the WS2 films.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
M. Mezyen, G. El Fidha, N. Bitri, F. Harrathi, I. Ly, E. Llobet
Summary: This paper explores the impact of dysprosium (Dy) doping on the structural, optical, and photocatalytic properties of tin oxide (SnO2) thin films. The results show that dysprosium doping can improve the crystalline quality and film quality, and can also change the crystal orientation. Additionally, dysprosium doping leads to the formation of numerous micro-aggregates on the film's surface. Importantly, SnO2:Dy 5% thin films exhibit high degradation efficiency under solar irradiation.
Article
Chemistry, Physical
Beya Ouertani, Habib Boughzala, Bertrand Theys, Hatem Ezzaouia
Summary: The incorporation of ruthenium into FeSe2 thin films has shown significant improvement in optical and electrical properties, making them promising for photovoltaic applications. The alloyed films exhibited N-type conductivity with high absorption coefficients and desired band gap values. The use of ruthenium as an alloying agent in FeSe2 thin films shows potential for various applications, especially in the field of photovoltaics.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Ceramics
Wei Ren, Heng Lu, Jia-Hao Wei, Ying Zhu, Dong-Xing Zhao, Qin Shi, Jun Wang, Jun-Bo Xia, Bo-Yu Zhang
Summary: In this study, Mn1.16Co0.96Ni0.48Cu0.4O4 thermistor films were fabricated on Si substrate, and the effects of annealing temperature, cation distribution, and oxidation reaction during film deposition on the structure and properties of Mn-Co-Ni-Cu-O films were investigated. The results showed that the electrical properties were optimized at an annealing temperature of 750 degrees C, while the second phase film at 950 degrees C had the worst optical properties. The oxidation reaction during film deposition helped to improve the surface morphology and optical properties of the films.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
B. Janarthanan, C. Thirunavukkarasu, S. Maruthamuthu, M. Aslam Manthrammel, Mohd Shkir, S. AlFaify, M. Selvakumar, Vasudeva Reddy Minnam Reddy, Chinho Park
Summary: This review article provides detailed discussions on different thin-film coating techniques used for coating Indium-doped Tin Oxide (ITO), explaining the working principles and properties of each technique. It also includes information on precursors, electrical and optical properties of ITO, resistivity, transparency, growth rate, and structure of the coated films, as well as characterization techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Materials Science, Multidisciplinary
Zhou Li, David W. W. Gardner, Yong Xia, Sikai Zhao, Aifei Pan, Nishit Goel, Stephen Bart, Chen Liu, Jianxin Yi, Carlo Carraro, Roya Maboudian
Summary: Ordered porous thin films of reduced graphene oxide and tin oxide (rGO/SnO2) were synthesized and their gas-sensing properties were studied. The incorporation of rGO significantly improved the humidity sensitivity and electrical conductivity of the sensor. The rGO/SnO2 composite film also demonstrated fast response time and excellent selectivity towards humidity, and showed long-term stability compared to a commercial humidity sensor.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Soobin Park, Jinmyeong Seo, Jungjoon Park, Inseong Hwang, Han-Seung Lee, Hyunsung Jung, Bongyoung Yoo
Summary: The fabrication of freestanding bendable films without polymer substrates as capacitive humidity-sensing materials is demonstrated. The films, prepared through simple methods, exhibit remarkable sensing performance in a wide range of humidity and have been confirmed reliable through cyclic and long-term sensing tests.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Ping-Che Lee, Yu-Liang Hsiao, Jit Dutta, Ruey-Chi Wang, Shih-Wen Tseng, Chuan-Pu Liu
Summary: This study explores the use of porous ZnO thin films to enhance the output voltage and sensitivity of piezoelectric nanogenerators. The presence of pores leads to lattice contraction in the c-direction, resulting in improved performance. Transmission electron microscopy characterizations confirm the mechanism behind the enhancements.
Article
Chemistry, Applied
Dasari Sunil Gavaskar, P. Nagaraju, M. V. Ramana Reddy
Summary: Oxygen vacancies, oxidation, and chemisorbed oxygen play crucial roles in the gas-sensing properties of metal oxide semiconductors. To enhance the gas-sensing performance, an effective method to improve chemisorbed oxygen on the material surface is needed. In this study, mesoporous In2O3 and RuO2-In2O3 nanocomposite porous structured thin films were prepared using the spray pyrolysis technique. The addition of RuO2 increased the chemisorbed oxygen on the film surface. Characterization of the prepared films included XRD, FESEM, AFM, TEM, UV-vis spectrophotometry, photoluminescence, XPS, and BET. The nanocomposite films exhibited high specific surface area and porosity, which favored their gas-sensing properties. Among all the samples, RuO2-In2O3 nanocomposite thin film with 20 wt% RuO2 concentration showed remarkable sensing properties towards 50 ppm benzene at room temperature.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Physical
Apurba Das, Varun Saxena, Aman Bhardwaj, Susmita Rabha, Lalit M. Pandey, Pamu Dobbidi
Summary: This study reports on bilayered thin films used for biomedical implants and analyzes their microstructural, surface, and electrical properties as well as their biocompatibility. The results show that these films have hydrophobicity and excellent cell viability, and their dielectric properties can assist in the fracture healing process. The study also analyzes the loss mechanisms in the films, providing insights into the parameters that regulate the decay of polarized fields and delay the healing process.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Bhubesh Chander Joshi, Aadarsh Kumar Chaudhri
Summary: In this study, Cu-doped ZnO thin films were prepared using the sol-gel method. The doping concentration was found to affect the crystallite size, band gap, and conductivity of the films. The doped films showed p-type conductivity initially but degraded with time. Ambient-exposed films converted to n-type, while vacuum-placed films maintained p-type behavior. It is suggested that if these films are well prepared, protected, and properly passivated, they can be used for optoelectronics devices.
Article
Chemistry, Applied
Pritam Sharma, John Dell, Giacinta Parish, Adrian Keating
Summary: Porous silicon films with high temperature coefficient of resistance and microfabrication compatibility are suitable candidates for thermal sensors. Surface passivation at 600 degrees Celsius can significantly reduce the 1/f noise in the films, leading to higher sensitivity in thermal sensors.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
Ahmed A. Aboud, Ayan Mukherjee, M. Al-Dossari, N. S. Abd EL-Gawaad, Ahmed M. Saad
Summary: We report the formation of hexagonal nano-sheets of pure and Co-doped ZnO thin films using aerosol-assisted chemical vapor deposition technique. Two phases of ZnO, Wurtzite and Zinc blende, were observed in the films by X-Ray diffraction. Scanning electron microscope images show the formation of hexagonal nano-sheets on the substrate surface. Beer's law was used to determine the band gap of the films. The performance of both films as UV detectors was investigated, with the response/decay time showing large values. Co-doping decreased the response time while increasing the decay time. The Co-doped ZnO films exhibited a minimum response time of 4s at 5V applied voltage, but had a lower gain value compared to the pure film.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Jijie Huang, Di Zhang, Zhimin Qi, Bruce Zhang, Haiyan Wang
Summary: In this study, Ag-LiNbO3 nanocomposite thin films were fabricated by co-deposition of Ag and LiNbO3, allowing for tailored density and size of Ag nanoparticles embedded in the matrix. The films exhibited surface plasmon resonance, tunable optical constants, and optical anisotropy, making them promising for photonic device applications.
NANOSCALE ADVANCES
(2021)
Article
Engineering, Environmental
Shikha Jain, Neeraj Dilbaghi, Nitin Kumar Singhal, Ajeet Kaushik, Ki-Hyun Kim, Sandeep Kumar
Summary: Accumulation of heavy metal ions in the ecosystem is a major concern for their negative effects on animals, humans, and aquatic habitats. A rapid and portable sensing system is crucial for detecting and managing such pollutants. A fluorescence-based biosensor has been developed for the selective and sensitive detection of Pb2+ ions using a DNAzyme system that responds only to the presence of lead (II) ions (Pb2+). This novel biosensing approach offers insights into the rapid and sensitive detection of major pollutants for food and environmental safety.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Shikha Bhogal, Irshad Mohiuddin, Ki-Hyun Kim, Ashok Kumar Malik, Kuldeep Kaur
Summary: A highly effective method using restricted access medium magnetic molecularly imprinted polymer (RAM-MMIP) for selective identification and isolation of phthalates (PTHs) has been established. The RAM-MMIP was synthesized using Fe3O4@SiO2 as support material, diethyl phthalate and dicyclohexyl phthalate as dual dummy templates, and (3-glycidyloxypropyl)trimethoxysilane as the silane coupling agent. The RAM-MMIP showed selectivity for PTHs and recyclability for multiple cycles, with successful application for extraction of PTHs from plastic packaged foods.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Dae-Hwan Lim, Younes Ahmadi, Young-Hyun Kim, Ki-Hyun Kim
Summary: Flavored capsule heat-not-burn (FC-HNB) tobacco products, including IQOS, Lil, and Glo, have been introduced as a new generation of cigarettes. These products release various volatile organic compounds (VOCs), and it is crucial to assess the potential harm associated with their use. The study evaluated the VOC composition in HNB cigarette vapor and found that breaking the capsules increased VOC concentrations significantly. Certain key VOC components, such as ethyl butyrate, isoamyl acetate, and limonene, were identified after breaking the flavored capsules. The research highlights the harmful effects of direct and indirect exposure to VOCs in FC-HNB products.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Bushra Fatima, Sharf Ilahi Siddiqui, Hament Kumar Rajor, Maqsood Ahmad Malik, Katabathini Narasimharao, Rabia Ahmad, Kumar Vikrant, Taejin Kim, Ki-Hyun Kim
Summary: In this study, a nano-photocatalyst consisting of zinc oxide coupled with cadmium tungstate was synthesized using lemon leaf extract. The photocatalytic activity of this nanocomposite was investigated for the degradation of Congo red dye under natural solar light irradiation. The results showed that the nano-photocatalyst exhibited excellent photocatalytic degradation performance, surpassing its pristine forms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Manpreet Kaur, Mohamad Yusuf, Yiu Fai Tsang, Ki-Hyun Kim, Ashok Kumar Malik
Summary: CdMOF and ZnMOF-NH2, metal-organic frameworks functionalized with amine/hydrazone ligands, were synthesized using a conventional reflux method. These MOFs exhibited good crystallinity and thermal stability. They were found to be efficient in the fast sensing of 2,4,6-trinitrophenol (TNP) in water with high sensitivity and selectivity, with limits of detection of 7 ppb and 10 ppb, respectively. The sensing mechanism was assessed using density functional theory calculations and spectral overlap analysis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Chemistry, Applied
Vikas Chaudhary, Praveen Lakhera, Ki-Hyun Kim, Akash Deep, Parveen Kumar
Summary: The extensive use of lithium-ion batteries has led to a large amount of waste. These wastes can be a source of valuable metals such as lithium, cobalt, manganese, and nickel. Recycling these batteries can help reduce the cost of production and minimize environmental impacts.
SEPARATION AND PURIFICATION REVIEWS
(2023)
Article
Engineering, Chemical
Xinzhi Wang, Deepak Kukkar, Sherif A. Younis, Kumar Vikrant, Younes Ahmadi, Danil Boukhvalov, Ki-Hyun Kim
Summary: Adsorbents with high surface area and diverse functional groups can effectively remove volatile organic compounds (VOCs) with different polarities. A metal-organic framework-199 (MOF-199)/powdered activated carbon (PAC) composite (MOF-199@PAC) was prepared and used to treat multiple VOC system containing both non-polar (benzene) and polar VOCs (methyl ethyl ketone). The composite showed efficient adsorption of polar and non-polar VOCs on its surface due to the presence of abundant pi-pi conjugated sites and polar groups, respectively.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Yang Sun, Vanish Kumar, Ki-Hyun Kim
Summary: Photocatalytic hydrogen evolution using graphitic carbon nitride (g-C3N4) is a feasible and environmentally friendly technology to address the energy crisis. This review discusses the advantageous photocatalytic properties of g-C3N4 for hydrogen generation and describes its mechanism and role in the photocatalytic process. The applicability of g-C3N4-based materials is further assessed based on figure of merit (FoM), and the most effective strategies identified include dye conjugation and metallic-co-catalyst doping of g-C3N4.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Monika Chhillar, Deepak Kukkar, Preeti Kukkar, Ki-Hyun Kim
Summary: Immunoassays have become an important analytical tool for the early-stage diagnosis and treatment monitoring of common diseases like chronic kidney disease (CKD). This review discusses the merits and demerits of various biomarkers for CKD diagnosis and explores different immunoassay types for detecting these biomarkers. It provides valuable insights into the recent advances in nanomaterial-antibody conjugate-based immunoassays for CKD-associated metabolites and biomarkers.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Green & Sustainable Science & Technology
Yahui Cai, Jianfei Wu, Sheldon Q. Shi, Jianzhang Li, Ki-Hyun Kim
Summary: The potential of seawater desalination technologies in addressing the freshwater shortage has been recognized. This paper provides a review of desalination technologies, including their working principles, environmental risks, merits, and economic benefits. Strategies to overcome the limitations of current solar desalination technologies are proposed, and future research directions are discussed. This paper is expected to serve as a valuable reference for freshwater production based on desalination techniques.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Environmental
Thi Yen Tran, Swati Verma, Sherif A. Younis, Ki-Hyun Kim
Summary: The potential application of ZnTON as an adsorbent for gaseous formaldehyde was investigated. ZnTON exhibited higher adsorption capacity than commercial P25-TiO2 and activated carbon. The adsorption capacity of ZnTON increased with higher initial feeding concentration of formaldehyde but decreased with rising temperature and moisture levels. The adsorption of formaldehyde onto ZnTON followed Langmuir isotherm and pseudo-second-order kinetic models. This study provides valuable insights for the synthesis of advanced adsorbents for the removal of volatile organic compounds.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Yang Sun, Sherif A. Younis, Ki-Hyun Kim, Vanish Kumar
Summary: This review discusses the fundamental aspects of bismuth oxyhalide (BiOX) photocatalysts in relation to their modification strategies and associated reduction mechanisms of CO2. The performance of BiOX materials is evaluated in terms of key performance metrics such as quantum efficiency, space-time yield, and figure of merit. The morphology design of BiOX materials is found to be the most efficient strategy for maximizing CO yield, while the introduction of heterojunctions is more suitable for CH4 formation. Therefore, the adoption of proper modification approaches is recommended for efficient CO2 conversion.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Correction
Chemistry, Physical
Priyanshu Goel, Shashank Sundriyal, Vishal Shrivastav, Sunita Mishra, Deepak P. Dubal, Ki-Hyun Kim, Akash Deep
Review
Chemistry, Multidisciplinary
Yongbiao Hua, Younes Ahmadi, Ki-Hyun Kim
Summary: This comprehensive review summarizes the recent progress in transition metal oxide (TMO)-based thermocatalysts for the removal of formaldehyde (FA). The key factors affecting the catalytic activity of TMO-based thermocatalysts towards FA are discussed, including exposed crystal facets, alkali metal/nitrogen modification, type of precursors, and alkali/acid treatment. The performance of TMO-based composite catalysts is found to be superior to mono- and bi-metallic TMO catalysts, owing to their abundant surface oxygen vacancies and enhanced FA adsorptivity. The challenges and future prospects for TMO-based catalysts in the catalytic oxidation of FA are also discussed.
Article
Chemistry, Multidisciplinary
Rajit Sikka, Pawan Kumar
Summary: Methylammonium lead bromide (MAPbBr(3)) was synthesized at room temperature using a chemical stirring method and characterized using various techniques. The optical properties of MAPbBr(3) were confirmed, and it was used for the optical detection of nitroaromatic compounds in hexane. The detection limits and selectivity of MAPbBr(3) were determined for various compounds.
JOURNAL OF CHEMICAL SCIENCES
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
