Journal
BIOSENSORS & BIOELECTRONICS
Volume 100, Issue -, Pages 23-27Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.08.038
Keywords
LSPR; QCM; Point-of-care
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Funding
- Engineering and Physical Sciences Research Council (EPSRC) [EP/K021966/1]
- EPSRC [EP/K021966/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K021966/1] Funding Source: researchfish
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We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.
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