Article
Biophysics
Jin Wang, Jiali Bei, Xu Guo, Yue Ding, Tingting Chen, Bing Lu, Yang Wang, Yukou Du, Yong Yao
Summary: An ultrasensitive and specific photoelectrochemical immunosensor has been developed for the detection of carcinoembryonic antigen (CEA). The immunosensor exhibits high specificity, good stability, and a sensitive linear response within the detection range.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Jin Wang, Jiali Bei, Xu Guo, Yue Ding, Tingting Chen, Bing Lu, Yang Wang, Yukou Du, Yong Yao
Summary: In this study, an ultrasensitive and specific photoelectrochemical (PEC) immunosensor was developed for the detection of carcinoembryonic antigen (CEA). The developed PEC immunosensor demonstrated high specificity, good stability, and excellent reproducibility, making it a promising tool for biomarker immunosensing.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Polina Skvortsova, Dmitriy Shurpik, Ivan Stoikov, Bulat Khairutdinov
Summary: The spatial separation and organization of chemical reactions are important for cell functioning. This is achieved through cellular compartments and membraneless organelles. These compartments contain complex molecules such as proteins, DNA, and RNA.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yan Cai, Xin Yan, Siyuan Wang, Zhiwen Zhu, Moupan Cen, Changjin Ou, Qin Zhao, Qian Yan, Jin Wang, Yong Yao
Summary: Researchers successfully designed and prepared a hybrid polymeric material incorporating Pd nanoparticles, which exhibited desirable catalytic activity for reductions of toxic nitroaromatics and C-C bond-forming reactions in aqueous solution.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Zhaona Liu, Bing Li, Leqian Song, Huacheng Zhang
Summary: Hybrid macrocyclic hosts containing rigid pillar[n]arene and flexible calix[m]arene were designed and prepared to reserve planar chirality, enhance molecular recognition, and build advanced self-assemblies. Different synthetic strategies were summarized and discussed for constructing hybrid macrocyclic structures. These structures exhibited interesting applications in molecular recognition, self-assembly, and catalysis.
Review
Biochemistry & Molecular Biology
Hayati Filik, Asiye Aslihan Avan, Mustafa Ozyurek
Summary: This review summarizes recent progress in constructing nanomaterial-based electrochemical immunosensors for prostate-specific antigen (PSA), with a focus on the use of metal, metal oxide, and carbon-based nanomaterials, as well as hybrid architectures for amplification of signals. The review classifies the electrochemical immunosensors for PSA sensing into three categories: sandwich type labeled, label-free non-labeled, and aptamer-based sensors.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jia-Rui Wu, Gengxin Wu, Zhi Cai, Dongxia Li, Meng-Hao Li, Yan Wang, Ying-Wei Yang
Summary: The study presents the design and synthesis of a water-soluble artificial receptor, CWP[5]L, which exhibits good binding affinities with certain aliphatic sulfonate species in aqueous solutions. Comparison experiments show that CWP[5]L outperforms its traditional water-soluble macrocyclic receptor counterpart in guest binding performance.
Review
Biochemistry & Molecular Biology
Iwona Nierengarten, Michel Holler, Marine Remy, Uwe Hahn, Aurelien Billot, Robert Deschenaux, Jean-Francois Nierengarten
Summary: Pillar[5]arenes with ten peripheral substituents are attractive scaffolds for constructing nanomaterials with controlled functional groups distribution. This review focuses on functionalizing pillar[5]arene derivatives with small dendrons to create dendrimer-like nanomaterials and bioactive compounds, such as non-viral gene vectors, bioactive glycoclusters, and liquid-crystalline materials.
Article
Chemistry, Analytical
Lichan Chen, Hongzhi Guo, Libing Tian, Shu-Feng Zhou
Summary: In this study, graphitic carbon nitride (g-CN) was molecularly engineered with phenyl groups to enhance its electrical conductivity. The resulting Ph-CN nanosheets (Ph-CNNS) exhibited stable and strong cathodic electrochemiluminescence (ECL) emission, which was used to develop an ECL immunosensor for the detection of cardiac Troponin I (cTnI). The ECL immunosensor showed promising performance in terms of linear response, detection limit, specificity, reproducibility, and long-term stability.
MICROCHEMICAL JOURNAL
(2022)
Review
Polymer Science
Xiao-Ni Qi, Qi Lin, Tai-Bao Wei, Wei Tian, Zhen-Liang Li
Summary: Among advanced materials, supramolecular gel (SG) materials based on pillar[5]arene have attracted significant attention due to their fine processability, recyclability, stimulus-responsiveness, and self-repair capabilities. This review thoroughly discusses the dependency relationship between multiapplication performance and design strategy of SGs based on pillar[5]arene. Various specific application examples are summarized, including fluorescence sensing, pollutant separation, stimulus conversion, self-healing, and dye removal. The opportunities, challenges, and prospects of pillar[5]arene-based SGs in this field are also discussed.
Review
Chemistry, Organic
Leqian Song, Le Zhou, Bing Li, Huacheng Zhang
Summary: The construction and application of fullerene-containing pillar[n]arene organic-inorganic hybrid composites/systems are discussed in this article. Supramolecular interactions and covalent bonds are involved in the preparation process. By utilizing supramolecular interactions, pillar[n]arenes provide hydrophobic and electron-rich cavities for complexing fullerene and its derivatives. The covalent bonds are formed during synthesis of coupled pillar[n]arene and fullerene hybrid composites, through modification of pillar[n]arenes with fullerene subunits or utilization of fullerene as a partial structural skeleton for building pillar[n]arenes. These hybrid composites find applications in various fields, including photodevices.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Nicholas Pearce, Katherine E. A. Reynolds, Surajit Kayal, Xue Z. Sun, E. Stephen Davies, Ferdinando Malagreca, Christian J. Schuermann, Sho Ito, Akihito Yamano, Stephen P. Argent, Michael W. George, Neil R. Champness
Summary: This study demonstrates the ability to control photoinduced charge transfer within homo- and hetero-rotaxanes through the organization of the components of mechanically interlocked molecules, introducing alternative pathways for electron donation.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jinwen Luo, Yunlong Guo, Ping Li, Andrew C-H Sue, Chuyang Cheng
Summary: We have synthesized and explored the dynamic covalent chemistry of an A1/A2-dimercapto-functionalized pillar[5]arene. The introduction of thiol moieties into this macrocyclic host enables its application as an effective building block for creating a dynamic combinatorial library, resulting in a collection of cyclic trimers with intriguing host-guest properties as the dominant constituents.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Bing Lu, Xin Yan, Jian Wang, Danni Jing, Jiali Bei, Yan Cai, Yong Yao
Summary: The first rim-differentiated pillar[5]arene based nonporous adaptive crystals (NACs) were developed and used to separate dichloromethane from a halomethane mixture with 99.1% purity.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Xu Zhou, Genfu Zhao, Xiaoping Tan, Xingcan Qian, Ting Zhang, Jingwei Gui, Long Yang, Xiaoguang Xie
Article
Biophysics
Xingcan Qian, Xu Zhou, Xin Ran, Hangcheng Ni, Zhi Li, Qing Qu, Jun Li, Guanben Du, Long Yang
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Analytical
Xu Zhou, Xingcan Qian, Xiaoping Tan, Xin Ran, Zhi Li, Zhangjie Huang, Long Yang, Xiaoguang Xie
ANALYTICA CHIMICA ACTA
(2019)
Article
Chemistry, Analytical
Xiaoping Tan, Shuhua He, Xi Liu, Genfu Zhao, Ting Huang, Long Yang
Article
Chemistry, Multidisciplinary
Siva Prasad Mooni, Kiran Kumar Kondamareddy, Sunling Li, Xin Zhou, Liu Chang, Xia Ke, Xiaoqiang Yang, Dan Li, Qing Qu
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Xiaoqian Hou, Zhi Li, Hongxing Yang, Shuang Tan, Tiantian Zhang, Jun Li, Hong Lei, Xin Ran, Guanben Du, Long Yang
Article
Chemistry, Multidisciplinary
Taohong Li, Bengang Zhang, Shuyang Jiang, Xiaojian Zhou, Guanben Du, Zhigang Wu, Ming Cao, Long Yang
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Zhiyong Ran, Hongxing Yang, Zhi Li, Kangnian Wang, Jiapeng Zhao, Xin Ran, Guanben Du, Long Yang
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Sichen Liu, Guanben Du, Hongxing Yang, Hang Su, Xin Ran, Jun Li, Lianpeng Zhang, Wei Gao, Long Yang
Summary: The synthesis of a hyperbranched cross-linking cellulose-based adhesive with a synergistic effect of covalent bonds and secondary bonds has significantly improved water resistance and dry lap shear strength, providing a potential method for preparing wood adhesive with excellent bonding performance and eminent water resistance based on green and cheap raw materials.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Organic
Yuan Zhang, Tongda Liu, Li Liu, Haiyang Guo, Heyang Zeng, Wei Bi, Guanyinsheng Qiu, Wei Gao, Xin Ran, Long Yang, Guanben Du, Lianpeng Zhang
Summary: A novel and facile protocol for the synthesis of benz[c,d]indol-2-imines was reported, which involves palladium-catalyzed C-C and C-N coupling reactions of 8-halo-1-naphthylamines with isocyanides in a single step. The reaction exhibits broad substrate scopes and mild conditions, providing an efficient alternative for the construction of antiproliferative agents and BET bromodomain inhibitors.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Agricultural Engineering
Hang Su, Guanben Du, Hongxing Yang, Yingchen Wu, Sichen Liu, Kelu Ni, Xin Ran, Jun Li, Wei Gao, Long Yang
Summary: This work proposes a new concept for a chemical wood bonding interface by tailoring the wood interface and polyamine adhesive. The activated wood interface shows super-strong bonding performance and water resistance through chemical bonding. The study provides new insights into designing an unbreakable and durable bonding interface for wood-based materials.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Environmental
Kelu Ni, Guanben Du, Chuanyin Liu, Yingchen Wu, Hongxing Yang, Chunyan Yin, Hang Su, Xin Ran, Wei Gao, Long Yang
Summary: Researchers developed a sustainable wood adhesive by using dialdehyde-functionalized nanocellulose (DAC) and amine-functionalized nanocellulose (AC) prepared from microcrystalline cellulose, and constructing a rigid bio-inspired mineralized cellulose framework (AC@SiO2) using tetraethoxysilane (TEOS) on a cellulose template. The DAC/AC@SiO2 structure achieved enhanced bonding properties through various bonds and interactions in the cellulose-based entanglement network. With a solid content of 20%, the adhesive exhibited dry and wet shear strengths of 2.05 and 1.26 MPa respectively.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Junyu Ren, Hongxing Yang, Yingchen Wu, Sichen Liu, Kelu Ni, Xin Ran, Xiaojian Zhou, Wei Gao, Guanben Du, Long Yang
Summary: In this study, a dynamic reversible adhesive based on simultaneous Michael addition reaction and Schiff base reaction was developed. The adhesive demonstrated excellent bonding performance on multiple substrates and showed promising recyclability.
Article
Chemistry, Multidisciplinary
Xiaoping Tan, Hongxing Yang, Xin Ran, Zhi Li, Lianpeng Zhang, Wei Gao, Xiaojian Zhou, Guanben Du, Long Yang
Summary: In this study, a CP6-AuNP-functionalized CNC nanohybrid with high electrocatalytic activity and excellent selective molecular recognition capability for BPA detection was prepared. The host-guest interactions were studied through fluorescence titration experiments, revealing a high binding constant between CP6 and BPA. The electrochemical sensing method showed satisfactory results for detecting BPA in tap water and milk samples.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Hongxing Yang, Guanben Du, Zhi Li, Xin Ran, Xiaojian Zhou, Taohong Li, Wei Gao, Jun Li, Hong Lei, Long Yang
Summary: This study verified the relationship between branching degree and bonding performance by synthesizing branched polyureas with different branching degrees. The results showed that the bonding strength of branched polyurea increased with an increase of terminal functional groups.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)