Review
Biotechnology & Applied Microbiology
Shivangi Sachdeva, Ronald W. Davis, Amit K. Saha
Summary: POCT allows physicians to detect and diagnose diseases faster than conventional lab-based testing, with particular importance in the COVID-19 pandemic. There are various point-of-care tests and diagnostic devices available in the market, including glucose monitoring, pregnancy testing, and infectious disease testing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Peng Chen, Chen Chen, Huiying Su, Mengfan Zhou, Shunji Li, Wei Du, Xiaojun Feng, Bi-Feng Liu
Summary: The integration of gLAMP and mu FAchip allows for simultaneous detection of different types of bacterial pathogens. The developed mu FAchip features a simple operation process with high specificity and sensitivity, making it a rapid and effective platform for pathogen detection, especially in field settings.
Article
Medicine, General & Internal
Bin-Feng Yin, Xin-Hua Wan, Ming-Zhu Yang, Chang-Cheng Qian, A. S. M. Muhtasim Fuad Sohan
Summary: This study developed a wave-shaped microfluidic chip assisted multiplexed detection platform, which enables rapid and sensitive detection of multiple biomarkers including CRP, PCT, and IL-6. The detection process is simple and shows good selectivity and repeatability, making it suitable for point-of-care testing.
MILITARY MEDICAL RESEARCH
(2022)
Review
Chemistry, Analytical
Mashooq Khan, Binglu Zhao, Wenli Wu, Mei Zhao, Yanhui Bi, Qiongzheng Hu
Summary: The development of a simple, fast, and low-cost technology for monitoring biofluids and environmental samples is urgently needed due to the increasing numbers of diseases caused by food toxins, environmental changes, and industrial outputs. The distance-based microfluidic analytical sensors (d -mu AS), which use distance as a readout signal, offer advantages such as simplicity, portability, eco-friendliness, instrument-free operation, affordability, and rapid detection. This review focuses on the progress in substrate preparation, application, advantages, challenges, and future directions of d -mu AS, providing valuable insights for researchers in developing high-quality biosensors and their applications in advanced engineering processes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Gaowa Xing, Jiebing Ai, Naiyu Wang, Qiaosheng Pu
Summary: POC testing is important in various fields and especially in resource-limited settings. Smartphone-based microfluidic sensors have emerged as a potential substitute for traditional laboratory instruments, thanks to their computational capability and data transferability.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Hamsa N. Gowda, Horacio Kido, Xunyi Wu, Oren Shoval, Adrienne Lee, Albert Lorenzana, Marc Madou, Michael Hoffmann, Sunny C. Jiang
Summary: The study developed a portable pathogen analysis system that can detect bacteria in water within 1 hour, with the advantages of simple operation and high sensitivity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biophysics
Zoe Bradley, Nikhil Bhalla
Summary: Sepsis is a life-threatening immune response caused by various sources and is a major cause of global mortality. Current molecular diagnostic techniques for sepsis are time-consuming and require trained personnel, and there is a lack of rapid point-of-care (POC) devices for sepsis detection. This review explores the use of microfluidics devices for POC testing and the potential of current and novel biomarkers for early sepsis diagnosis, aiming to develop more rapid and accurate methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Suchanat Boonkaew, Katarzyna Szot-Karpinska, Joanna Niedziolka-Jonsson, Barbara Palys, Martin Jonsson-Niedziolka
Summary: This study presents a novel sequential flow-through microfluidic device for assessing the risk of cardiovascular disease using C-reactive protein as the model analyte. The device features dual flow behaviors and requires only a single buffer loading, resulting in a total analysis time of 15 minutes. The integration of the P3-CRP peptide as a new bioreceptor enhances the performance of the device.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Jiaqi Wang, Lei Tan, Wenchao Bi, Haoyu Shen, Dengfeng Li, Zhenzhong Yu, Ning Gan
Summary: This study developed a microfluidic immunosensor for ultrasensitive detection of Staphylococcus aureus (S. aureus) using stir bar enrichment and DNAzyme-assisted click reaction. The method showed excellent sensitivity and simplicity, with satisfactory results in detecting real samples.
Review
Chemistry, Analytical
Naseem Abbas, Sehyeon Song, Mi-Sook Chang, Myung-Suk Chun
Summary: Bacterial infections, specifically Escherichia coli (E. coli) O157:H7, pose a serious threat to public health and require rapid and accurate detection methods. Traditional approaches like PCR and ELISA have limitations in terms of time and cost. Microfluidic platforms based on SPR, electrochemical sensing, and RCA offer promising alternatives for the detection of pathogens, providing rapid and portable point-of-care diagnostic tools.
Article
Chemistry, Multidisciplinary
David S. Kinnamon, Jacob T. Heggestad, Jason Liu, Thu Nguyen, Vo Ly, Angus M. Hucknall, Cassio M. Fontes, Rhett J. Britton, Jian-Piao Cai, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Thuy Le, Ashutosh Chilkoti
Summary: We developed a self-contained immunoassay platform that can be used in field settings with varied temperature, humidity, and blood samples. The platform has high sensitivity and accuracy in detecting analyte concentration, and a portable detection device. We also improved the microfluidic cassette for better usability and faster results. By using this platform, we successfully conducted a rapid diagnostic test for talaromycosis infection in patients, showing comparable sensitivity and specificity to laboratory tests.
Article
Chemistry, Analytical
Dongxu Zhang, Runxin Gao, Shaolei Huang, Yulin Huang, Jianbin Zhang, Xiaosong Su, Shiyin Zhang, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: In this study, a microfluidic chip is proposed for on-site and rapid nucleic acid detection. The system has the advantages of high integration, low cost, and potential for large-scale production. It can be used for wide range screening during the COVID-19 pandemic and shows promising clinical application prospects.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Lihang Zhu, Wenxuan Fu, Boyu Zhu, Qian Feng, Xudong Ying, Shuang Li, Jing Chen, Xiaoya Xie, Chenying Pan, Jun Liu, Chao Chen, Xing Chen, Danhua Zhu
Summary: Heart-type fatty acid binding protein (H-FABP) is an early biomarker for acute myocardial infarction. Researchers developed an electrochemiluminescence device integrated with a microfluidic chip (m-ECL device) for on-site detection of H-FABP. The device enables direct detection of H-FABP in human serum without any pre-treatment and shows promising application prospects for point-of-care testing of acute myocardial infarction.
Article
Food Science & Technology
Xuan Weng, Cheng Zhang, Hai Jiang
Summary: Rapid and accurate detection of foodborne pathogens is crucial for preventing outbreaks, and microfluidic nanobiosensors show promise in achieving this by reducing assay time, enhancing sensitivity, and improving accuracy.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jiajia Liu, Huili Wang, Li Zhang, Ying Lu, Xu Wang, Minjie Shen, Nan Li, Li Feng, Juhui Jing, Bin Cao, Xiaohui Zou, Jing Cheng, Youchun Xu
Summary: The ongoing COVID-19 pandemic has had a profound impact on the global healthcare system and daily lives of people. This has resulted in insufficient surveillance of coinfection or resurgence of other critical respiratory epidemics. To address this issue, a microfluidic system (MAPnavi) has been developed for rapid and sensitive diagnosis of multiple respiratory viruses, showing promising results in detecting coinfections among patients with COVID-19.
Article
Hematology
Hyunji Kim, Daehyun Chu, Miyoung Kim, Young-uk Cho, Chan-jeoung Park, Seongman Bae, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Sung-Han Kim
Summary: This study suggests that Lupus anticoagulants (LA) are associated with disease severity in COVID-19 patients. The majority of LA-positive patients showed LA positivity within 10 days of SARS-CoV-2 infection, while a subgroup of patients initially tested negative for LA during the early stages of infection and became positive later.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Correction
Medicine, General & Internal
Jiwon Jung, Sun-Kyung Kim, Yumi Lee, Soyeon Park, Young-Ju Lim, Eun Ok Kim, Sung-Han Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Sungim Choi, Song Mi Moon, Ji-Soo Kwon, Sung-Han Kim, Seong Yeon Park
Summary: The study evaluated the diagnostic usefulness of varicella zoster virus (VZV) specific IgA and IgG antibodies in patients with herpes zoster (HZ). The results showed significant differences in the levels of VZV-specific IgA and IgG antibodies between HZ patients and healthy controls.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Jiyoung Lee, Euijin Chang, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Seongman Bae
Summary: This study evaluated the rate and composition of bacterial co-infection in COVID-19 patients and assessed the association between the use of empirical antibacterials and mortality. The results showed that bacterial co-infection was infrequent in the patients, and the co-infected organisms varied depending on the previous use of antibacterial drugs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Dermatology
Hyejin Park, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim, Jiwon Jung
Summary: This study retrospectively analyzed the clinical characteristics and outcomes of invasive and non-invasive fusariosis in South Korea. Invasive fusariosis mainly affected immunocompromised patients and was associated with a poor prognosis. Non-invasive fusariosis was common in patients with diabetes and solid cancer.
Letter
Infectious Diseases
Song Hee Namgung, Jiwon Jung, Sun Kyung Kim, Eun Ok Kim, Kyung-Wook Jo, Tae Sun Shim, Sung-Han Kim
JOURNAL OF INFECTION
(2023)
Article
Chemistry, Analytical
Hyo Joo Lee, Nam Hun Kim, Eun Hye Lee, Young Soon Yoon, Yun Jeong Jeong, Byung Chul Lee, Bonhan Koo, Yoon Ok Jang, Sung-Han Kim, Young Ae Kang, Sei Won Lee, Yong Shin
Summary: This study proposes a simple tuberculosis molecular diagnostic assay that combines sample preparation and DNA detection steps. The sample preparation is done using a syringe filter with amine-functionalized diatomaceous earth and homobifunctional imidoester, and the target DNA is detected using quantitative PCR. The system has a detection limit that is 10 times higher than conventional PCR assays and can provide results within 2 hours from large volume samples without additional instruments. The clinical utility of the proposed method was validated in 88 sputum samples from four hospitals in the Republic of Korea, showing superior sensitivity compared to other assays. Therefore, this system can be useful for MTB diagnosis in limited-resource settings.
Article
Immunology
Jin Young Ahn, Jae-Hoon Ko, Kyong Ran Peck, Seongman Bae, Sung-Han Kim, Kyoung Hwa Lee, Young Goo Song, Yong Chan Kim, Yoon Soo Park, Kyoung-Ho Song, Eu Suk Kim, Hye Won Jeong, Shin-Woo Kim, Ki Tae Kwon, Won Suk Choi, Jun Yong Choi
Summary: This study investigated the long-term kinetics of immune responses after heterologous booster vaccination and the impact of Omicron breakthrough infection. The findings showed that participants who experienced breakthrough infection during the BA.1/BA.2 period had a more robust increase in neutralizing antibody titers against the wild-type virus compared to BA.1 and BA.5.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Gahee Kim, Ree Nar Yoo, Hyejin So, Jeong-Young Lee, Mi-Na Kim, Sung-Han Kim, Won Kyoung Jhang, Seong Jong Park, Jina Lee
Summary: Ralstonia mannitolilytica is a causative organism of nosocomial infections, particularly associated with contaminated water, and resistant to various antibiotics, including carbapenems. In this study, 18 patients with R. mannitolilytica infection were included, with 94.4% diagnosed with pneumonia and 5.6% with central line-associated bloodstream infection. The all-cause 30-day mortality rate was 61.1%, and environmental sampling identified R. mannitolylica at a cold-water tap of a water purifier and an exhalation circuit of a patient mechanical ventilator.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Letter
Immunology
Jiwon Jung, Ji Yeun Kim, Ji-Soo Kwon, Sung-Cheol Yun, Sung-Han Kim
Article
Medicine, General & Internal
Jiwon Jung, Sun-Kyung Kim, Yumi Lee, Soyeon Park, Young-Ju Lim, Eun Ok Kim, Sung-Han Kim
Summary: This study compares the rates of COVID-19 infection in healthcare workers (HCWs) working in COVID-19 designated wards and general wards. The findings show that HCWs in designated wards have a lower rate of contracting COVID-19. Possible factors contributing to this finding include a lack of exposure to undiagnosed cases and their caregivers, greater care with social distancing outside the hospital, higher rates of 3-dose vaccinations, and the use of isolation rooms with negative pressure.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Jiwon Jung, Jungmin Lee, Sun-Kyung Kim, Soyeon Park, Young-Ju Lim, Eun Ok Kim, Heedo Park, Man-Seong Park, Sung-Han Kim
Summary: Four additional cases of COVID-19 were reported in a hematologic ward in South Korea, after an 8-week isolation of a patient with prolonged viral shedding. Whole-genome sequencing revealed no evidence of transmission from the patient with prolonged positive RT-PCR.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Jiwon Jung, Jihye Jeong, Min Jee Hong, Eun Ok Kim, Min Jae Kim, Sung Eun Chang, Sung-Han Kim
Summary: A 64-year old woman who underwent lung transplantation contracted classic scabies from her daughter, despite multiple treatments and negative tests. The recurrence may be attributed to the inaccurate application of topical treatment and failure to change the tie string.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Immunology
So Yun Lim, Young-In Yoon, Ji Yeun Kim, Eunyoung Tak, Gi-Won Song, Sung-Han Kim, Sung-Gyu Lee
Summary: COVID-19 vaccination in liver transplant recipients may result in weaker immune responses. mRNA vaccines induce higher antibody responses compared to the ChAdOx1 vaccine, in recipients who received two doses.
Article
Medicine, General & Internal
Jiwon Jung, Jungmin Lee, Heedo Park, Young-Ju Lim, Eun Ok Kim, Man-Seong Park, Sung-Han Kim
Summary: This study reports a rapid nosocomial transmission of COVID-19 from a fully vaccinated patient in a hospital. Investigations on airflow and virus genome sequencing confirmed the transmission route. The index case, who frequently walked in corridors, had his air circulated into the resident on-call room, leading to the infection of on-call doctors. This study highlights the importance of infection control in hospitals.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)