Article
Materials Science, Multidisciplinary
Jincheng Zhang, Huatian Duan, Ying Hong, Jingyu Deng, Li-Juan Fan
Summary: A series of cationic conjugated polymers were synthesized for the detection of ATP, and the fluorescence of the polymers was quenched upon adding ATP. The sensitivity of the polymer to ATP increased with the density of the quaternary ammonium group. The study provides a general strategy for designing sensing systems for biomolecules with complex structures.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Spectroscopy
Zhifeng Cai, Shulin Pang, Liangliang Wu, Erxiao Hao, Jiaxin Rong
Summary: Dopamine-protected copper nanoclusters were utilized as a novel fluorescent nanosensor for the detection of nitrofurantoin. The sensor demonstrated good linear relationship and low detection limit, and was successfully applied for NFT detection in bovine serum samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The development of transient electronic devices is crucial for protecting sensitive information stored in electronic memory devices. A flexible electronic device with a highly water-soluble active material has been successfully fabricated, showing rewritable resistive random access memory effect and history-dependent memristive switching performance. This device emulates the learning and memorizing functions of biological systems and can be rapidly destroyed by adding water.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The key to protecting sensitive information stored in electronic memory devices is to develop transient electronic devices that can be quickly destroyed in an emergency. Researchers have successfully fabricated a flexible electronic device capable of protecting sensitive information by using a highly water-soluble active material. This device can emulate the learning and memorizing functions of biological systems and can be rapidly destroyed when water is added.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Shan Pu, Chengyan Xia, Lan Wu, Kailai Xu
Summary: Synthesized Cys-PVP-CuNCs were utilized for a sensitive detection of trace Sn4+, showing a linear range for detection, low detection limit, and noticeable fluorescent color change visible to the naked eye. The proposed fluorescent probe exhibits high sensitivity, stability, simplicity, selectivity, and is expected to be used for real-time field detection of Sn4+.
MICROCHEMICAL JOURNAL
(2022)
Article
Polymer Science
Sultan Sacide Gelen, Tuvshinjargal Munkhbat, Zuale Rexhepi, Fatma Ozturk Kirbay, Hacer Azak, Dilek Odaci Demirkol
Summary: Conducting polymers can be used to prepare electrochemical and optical detection platforms for bioanalytical systems. In this study, a multifunctional monomer was synthesized for selective detection of H2O2, successfully immobilizing CAT on Poly(DTP-Trp) for target analyte detection. Surface characterization was done using SEM and EDX, confirming the presence of Poly(DTP-Trp)/CAT on ITO-PET surfaces.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Spectroscopy
Feng Zhu, Kang Wang, Tongmou Geng
Summary: A hexaphenylsilole-based conjugated microporous polymer with high sensitivity and selectivity for sensing was synthesized through a catalytic reaction, demonstrating a large surface area and pore volume.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Anastasia Yakusheva, Mohamed Aly-Eldeen, Alexander Gusev, Olga Zakharova, Denis Kuznetsov
Summary: Amino- and carboxyl-functionalized carbon quantum dots (Amino-CQDs) were synthesized through a microwave treatment of a citric acid, ethylenediamine, and EDTA mix. The Amino-CQDs showed promising fluorescence properties and high sensitivity towards copper ions. They also demonstrated stable fluorescence parameters in alkali metal solutions and sea water. A visual sensor based on Amino-CQDs was successfully developed and could register colorimetric effects using computer vision software.
Article
Spectroscopy
Sai Jin Xiao, An Ting Qiu, Hui Han Li, Meng Ping Wang, Li Zhang, Kai Xin Guo, Jing Guo, Jian-Ding Qiu
Summary: In order to ensure the long-term sustainable development of nuclear energy and prevent uranium pollution, there is an urgent need for new materials that can detect and separate uranium simultaneously. In this study, a new fluorescent covalent organic polymer (COP) named HT-COP-AO was synthesized and used as a fluorescent probe and absorbent for uranium detection and separation. The results showed that HT-COP-AO had a strong fluorescence quenching effect on uranium with a detection limit of 0.23 μM. It was found that uranium was coordinated with the amidoxime groups of HT-COP-AO through U-N and O = U = O bonds, leading to electron transfer and fluorescence quenching.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Materials Science, Multidisciplinary
Yifan Zhang, Zejian He, Xinyi Shen, Liangliang Zhu, Dongqi Wang, Yulong Chen, Mi Zhou
Summary: In this study, a multiresponsive fluorescent probe was designed using a synthetic water-soluble conjugated fluorescent polymer. The polymer showed high sensitivity and selectivity towards reductive species-thiols and oxidizing substances through fluorescence resonance energy transfer (FRET) and heavy atom effect mechanisms. The detection limits for mercaptan, H2O2, and glucose were determined, and the multiple detection ability of the polymer was validated in food samples and tissue homogenates. This study provided a strategy for integrating multiple species detection capabilities on a single probe.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Analytical
Fengxia Su, Xiaofei He, Pengbo Zhang, Hui Wang, Zhengping Li
Summary: The COVID-19 epidemic caused by the SARS-CoV-2 virus has had a significant negative impact on society and global health. A sensitive, quick, and reasonably priced SARS-CoV-2 detection technology is urgently needed. Reverse transcription-loop-mediated isothermal amplification (RT-LAMP) is a promising method that amplifies a small amount of RNA to a detectable level at isothermal condition without the need for expensive equipment. In this study, a water-soluble polythiophene-based colorimetric method combined with RT-LAMP was established for fast and sensitive detection of SARS-CoV-2 RNA.
Article
Chemistry, Physical
Subash Vetri Selvi, Varghese Lincy, Shen-Ming Chen, Po-Da Hong, Adhimoorthy Prasannan
Summary: A water-soluble Sr-NiO@P3ThA nanocomposite material was synthesized and utilized as an effective electrode for detecting water-soluble catechol contaminations. The modified electrode exhibited good selectivity and sensitivity, successfully detecting catechol in river water and tap water. An eco-friendly, water-soluble, simple, sensitive, and selective approach for determining catechol contaminations in water resources was established.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Melinda Einsla, Vlad Telyatnikov, Johnpeter Ngunjiri, Sipei Zhang, Gary Dombrowski
Summary: In this study, a series of soluble-shell polymers were synthesized using an acrylic composition with an end-chain alkoxysilane crosslinkable moiety. The crosslinking was achieved by using MPTMS as a chain transfer agent, which effectively reduced the molecular weight of the acrylic. The resulting dried films showed improved mechanical properties and thermo-mechanical stability.
Article
Materials Science, Multidisciplinary
Shu-Li Chen, Yan Mi, Ling-Jie Zhang, Qing-Qing Lu, Fei-Long Hu, David James Young
Summary: Four fluorescent coordination polymers were synthesized and successfully used to detect folic acid through concentration-dependent fluorescence quenching.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Adedibu C. Tella, Victoria T. Olayemi, Folahan A. Adekola, Adetola C. Oladipo, Vincent O. Adimula, Joseph O. Ogar, Eric C. Hosten, Adeniyi S. Ogunlaja, Stephen P. Argent, Robert Mokaya
Summary: In recent years, there has been significant interest in designing luminescent materials for detecting explosives, with a focus on selectivity, sensitivity, and fast response time. Two new luminescent compounds, 1 and 2, were synthesized and characterized for their potential applications in detecting nitroaromatic compounds. Compound 2 demonstrated stronger quenching ability towards nitro analytes compared to compound 1.
INORGANICA CHIMICA ACTA
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)