Journal
BIORHEOLOGY
Volume 54, Issue 5-6, Pages 153-165Publisher
IOS PRESS
DOI: 10.3233/BIR-18166
Keywords
Radial migration; axial accumulation; red cell deformability; membrane shear modulus
Categories
Funding
- JSPS KAKENHI [17H03176]
- ORDIST Group Fund
- Advanced Research Promotion Fund at Kansai University
- Grants-in-Aid for Scientific Research [17H03176] Funding Source: KAKEN
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BACKGROUND: In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE: To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes. METHODS: The cross-sectional distributions of normal and hardened RBCs as well as softened RBCs suspended in capillary tube flows were measured with high spatial resolution. A new observation system was developed in which enface views of the cross-section of the tube were obtained at small distances upstream of the outlet at various longitudinal positions in the tube. RESULTS: The radial positions of individual RBCs were detected within 1 mu m accuracy. It was found that normal and softened RBCs rapidly migrated away from the wall towards the tube axis, whereas glutaraldehyde-hardened RBCs were dispersed widely over the tube cross-section, depending on the concentration of glutaraldehyde solution. CONCLUSIONS: The newly devised observation system revealed quantitatively the essential role of RBC deformability in their axial accumulation.
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