Journal
BIOPHYSICAL JOURNAL
Volume 115, Issue 1, Pages 26-30Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2018.05.033
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Funding
- National Science Foundation Science and Technology Center for Emergent Behaviors of Integrated Cellular Systems [CBET-0939511]
- National Institutes of Health [R01GM107103]
- Allen Discovery Center program through The Paul G. Allen Frontiers Group
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1614948] Funding Source: National Science Foundation
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Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.
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