Article
Genetics & Heredity
He Cai, Wenjuan Ren, Hui Wang, Juanzi Shi
Summary: The choice of fertilization method can impact the secondary sex ratio (SSR) following blastocyst transfer (BT) in assisted reproductive technology (ART). This study found that the SSR was significantly higher after BT with ICSI procedures compared to ICSI cleavage-stage embryo SET. However, this effect was not observed with IVF treatment. The quality of the trophectoderm of the blastocyst was significantly associated with an elevated SSR.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Huijun Chen, Jian Li, Sufen Cai, Sha Tang, Suimin Zeng, Chang Chu, Carl-Friedrich Hocher, Benjamin Rosing, Bernhard K. Kramer, Liang Hu, Ge Lin, Fei Gong, Berthold Hocher
Summary: Blastocyst transfer after in vitro fertilization/intracytoplasmic sperm injection increases the risk of developing gestational diabetes mellitus (GDM).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Aisling Ahlstrom, Kersti Lundin, Anna-Karin Lind, Kristina Gunnarsson, Goran Westlander, Hannah Park, Anna Thurin-Kjellberg, Steinunn A. Thorsteinsdottir, Snorri Einarsson, Mari Astrom, Kristina Lofdahl, Judith Menezes, Susanne Callender, Cina Nyberg, Jens Winerdal, Camilla Stenfelt, Brit-Randi Jonassen, Nan Oldereid, Lisa Nolte, Malin Sundler, Thorir Hardarson
Summary: The use of a commercially available time-lapse algorithm for Day 5 blastocyst selection did not improve ongoing pregnancy rates compared with morphology alone.
HUMAN REPRODUCTION
(2022)
Article
Biology
Minh Tam Le, Thai Thanh Thi Nguyen, Trung Van Nguyen, Hong Nhan Thi Dang, Quoc Huy Vu Nguyen
Summary: Extending the culture of vitrified-warmed cleavage embryos for blastocyst transfer showed significantly better pregnancy outcomes compared to day 2 embryo transfer using cryopreserved embryos, especially for patients with previous cleavage embryo transfer failures. The development rate of blastocysts in the D2-5 CET group was 52.77%, and the pregnancy outcomes in terms of hCG positivity, clinical pregnancy, and implantation rates were significantly improved compared to the D2 CET group, with no significant differences compared to the D5 CET group.
Review
Obstetrics & Gynecology
Romualdo Sciorio, Marcos Meseguer
Summary: The main aim of assisted reproductive technology is to achieve a healthy singleton live birth, and the introduction of time-lapse monitoring technology has enabled embryologists to more accurately assess embryo status and implantation potential.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Genetics & Heredity
Romualdo Sciorio, D. Thong, K. J. Thong, Susan J. Pickering
Summary: Optimizing embryo culture and selection is crucial for maintaining pregnancy rates following single embryo transfer, where time-lapse monitoring can play a key role. This study evaluated the association between blastocyst morphology and pregnancy outcomes, finding that blastocyst width and area were significantly larger in pregnant women, with a positive correlation to clinical pregnancy rates. More studies are needed to confirm these observations.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Han-Chih Hsieh, Chun- Lee, En-Yu Lai, Jia-Ying Su, Yi-Ting Huang, Wei-Lin Zheng, Chien-Hong Chen, Chun-Chia Huang, Pin-Yao Lin, Maw-Sheng Lee, Mark Liu, Yen-Tsung Huang
Summary: This study compared the outcomes of Day 3 and Day 5 embryo transfer in IVF patients and found that for women without strong indications, Day 5 transfer had a small but significant advantage in implantation rate, while there were no distinguishable differences in odds of live birth and clinical pregnancy rate between the two protocols.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Obstetrics & Gynecology
Quinton S. Katler, Jennifer F. Kawwass, Bradley S. Hurst, Amy E. Sparks, David H. McCulloh, Ethan Wantman, James P. Toner
Summary: The practice of in vitro fertilization has undergone significant changes over the years, leading to a reduction in the rate of twin pregnancies. This improvement can be attributed to advancements in laboratory techniques, preimplantation genetic testing, and revised guidance on embryo transfer. Single-embryo transfer has become the standard of care, resulting in a dramatic decrease in multifetal pregnancies without compromising treatment effectiveness.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Endocrinology & Metabolism
Jianeng Zhang, Chong Wang, Huanhuan Zhang, Yan Zhou
Summary: Sequential embryo transfer has a higher clinical pregnancy rate compared to conventional cleavage embryo transfer, for both women who have experienced repeated implantation failure and those who have not. However, sequential embryo transfer does not show significant benefits over blastocyst embryo transfer.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Daniel Veraguas-Davila, Maria Francisca Cordero, Soledad Saez, Darling Saez-Ruiz, Alejandro Gonzalez, Fernando Saravia, Fidel Ovidio Castro, Lleretny Rodriguez-Alvarez
Summary: The study evaluated the effects of zona pellucida removal on the in vitro and in vivo development of domestic cat embryos. Results showed that removal of the zona pellucida negatively impacted gene expression and prevented successful implantation of the embryos.
Article
Obstetrics & Gynecology
Hyun Jin Kim, Jae Kyun Park, Jin Hee Eum, Haengseok Song, Woo Sik Lee, Sang Woo Lyu
Summary: Selecting a high-quality embryo is crucial for improving pregnancy outcomes, with blastocoel expansion and inner cell mass grade being important predictors for ongoing pregnancy. Embryos developing into blastocysts on day 5 and having higher expansion grades in pre-vitrified blastocysts are associated with successful pregnancy outcomes in single vitrified-warmed blastocyst transfer cycles.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yuqiong Wang, Sheng Wang, Xilin Qian, Yanrong Kuai, Yang Xu
Summary: A single-center, large-cohort, retrospective study compared embryonic development in group culture systems with or without G4 embryos, revealing that multiple G4 embryos have a negative impact on neighboring embryos, while polypronuclear embryos contribute positively. LC-MS/MS analysis of G1-G4 embryo secretome showed that certain proteins secreted by G4 embryos may harm nearby embryos, emphasizing the importance of limiting the number of G4 embryos in group culture settings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pin-Yao Lin, Chia-Yun Lin, Ni-Chin Tsai, Fu-Jen Huang, Hsin-Ju Chiang, Yu-Ju Lin, Yu-Ting Su, Kuo-Chung Lan
Summary: Extending the culture of morphologically poor embryos (MPEs) does not increase the live birth rate in fresh transfer cycles, but it results in significantly higher live birth rates when followed by frozen embryo transfer (FET) in younger females.
BIOMEDICAL JOURNAL
(2022)
Review
Obstetrics & Gynecology
Yutao Li, Siqiao Liu, Qun Lv
Summary: In a study involving 1784 patients, single blastocyst stage transfer (SBT) was found to have significantly higher clinical pregnancy rate, ongoing pregnancy rate, and delivery rate compared to single cleavage stage transfer (SCT). However, there were no significant differences between the two groups in terms of miscarriage rate, multiple pregnancy rate, and ectopic pregnancy rate, with the SCT group containing more cryopreserved embryos. Further larger and higher-quality RCTs are needed for a fully informed decision.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lin Wang, Jing Wang, Nan Lu, Jiayin Liu, Feiyang Diao
Summary: This study found that for women with previous cesarean sections, the pregnancy outcomes were similar to those with previous vaginal delivery in single embryo transfer cycles, and the presence of cesarean scar defect (CSD) was associated with a significant reduction in live birth rate, especially in patients with large CSD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Daniel Bodri, Takeshi Sugimoto, Jazmina Yao Serna, Satoshi Kawachiya, Ryutaro Kato, Tsunekazu Matsumoto
FERTILITY AND STERILITY
(2016)
Article
Genetics & Heredity
Daniel Bodri, Satoshi Kawachiya, Takeshi Sugimoto, Jazmina Yao Serna, Ryutaro Kato, Tsunekazu Matsumoto
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2016)
Article
Reproductive Biology
Daniel Bodri, Robert Milewski, Jazmina Yao Serna, Takeshi Sugimoto, Ryutaro Kato, Tsunekazu Matsumoto, Satoshi Kawachiya
REPRODUCTIVE BIOLOGY
(2018)
Article
Obstetrics & Gynecology
Satoshi Kawachiya, Daniel Bodri, Toshikazu Hirosawa, Jazmina Yao Serna, Akira Kuwahara, Minoru Irahara
REPRODUCTIVE MEDICINE AND BIOLOGY
(2019)