Review
Biology
Isaac Kyei-Barffour, Miranda Margetts, Alla Vash-Margita, Emanuele Pelosi
Summary: MRKH syndrome is a disorder caused by Mullerian ducts dysgenesis affecting women with a typical karyotype. The etiology is complex and largely unexplained, with possible genetic and epigenetic factors involved. Understanding the molecular mechanisms and improving clinical management remains a challenge due to limited research in functional validation and translational studies.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ryuma Haraguchi, Gen Yamada, Aki Murashima, Daisuke Matsumaru, Riko Kitazawa, Sohei Kitazawa
Summary: The development of the female reproductive tract in mammals relies on the interaction between Wolffian ducts (WDs) and Mullerian ducts (MDs), regulated by Hedgehog (Hh) signaling. Deficiency of Sonic hedgehog (Shh), exclusively expressed in WDs, prevents the MD mesenchyme from affecting uterine growth. In vivo cell tracking reveals that cells responding to WD-derived Hh signal continue to contribute to the formation of various tissues in the developing female reproductive tract.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Sofie Svanholm, Moa Safholm, Nanna Brande-Lavridsen, Erika Larsson, Cecilia Berg
Summary: The study utilized the model frog Xenopus tropicalis to investigate the effects of propiconazole exposure on endocrine perturbations and subsequent adverse effects. It was found that propiconazole increased brain aromatase activity and accelerated metamorphosis in tadpoles, indicating a stimulatory effect on the thyroid system. However, at puberty, hepatic and reproductive effects were evident, suggesting persistent disruption of metabolism and male reproductive function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Hannah Martin, Julian Rupkey, Shravan Asthana, Joy Yoon, Shray Patel, Jennifer Mott, Zifei Pei, Yingwei Mao
Summary: The exon junction complex (EJC) plays a crucial role in regulating gene expression and has potential implications in cancer and neurodevelopmental disorders. The understanding of its function in the cell cycle and its relation to diseases provide potential avenues for therapeutic targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Shravan Asthana, Hannah Martin, Julian Rupkey, Shray Patel, Joy Yoon, Abiageal Keegan, Yingwei Mao
Summary: The exon junction complex (EJC) is a complex that plays an important regulatory role in the central nervous system (CNS) and other tissues. It consists of several core proteins and auxiliary factors, and regulates multiple levels of gene expression. Dysfunction of the EJC is implicated in various developmental and neurological diseases.
Article
Medicine, General & Internal
Rebecca Buchert, Elisabeth Schenk, Thomas Hentrich, Nico Weber, Katharina Rall, Marc Sturm, Oliver Kohlbacher, Andre Koch, Olaf Riess, Sara Y. Brucker, Julia M. Schulze-Hentrich
Summary: By analyzing the genetic material of discordant monozygotic twins with MRKH, potential genetic causes were identified. The study revealed the involvement of estrogen in the pathology of MRKH, although no clear pathogenic differences were detected.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anatomy & Morphology
Carlos A. Serrano-Perez, Martha Patricia Ramirez-Pinilla
Summary: The study of male reproductive tract of Caecilia thompsoni individuals of different body sizes reveals that after reaching sexual maturity, morphological characteristics are consistent at macroscopic and histological level. The complementary secretory role between Wolffian and Mullerian glands suggests a functional coordination between the two ducts in the reproductive system. Despite slight differences, the overall morphological characteristics of the reproductive tracts of adult males of C. thompsoni follow the known pattern for reproductively active males of Gymnophiona.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Article
Medicine, General & Internal
M. L. Djordjevic, M. Bizic, B. Stojanovic, O. Ivanovski, R. Purohit
Summary: Urethral intercourse is a rare condition that can cause urinary incontinence, especially in patients with vaginal anomalies. This study evaluated the outcomes of genital and urethral reconstruction in 8 young women who experienced consequences of urethral sexual intercourse. The results showed that surgical treatment achieved good esthetical and functional results, with satisfactory sexual intercourse reported by all patients.
Article
Reproductive Biology
Xiaotian Lin, Caiyun Wang, Qi Zhang, Yi-Hsuan Pan, Suying Dang, Wei Zhang
Summary: ADAMTS18 plays a crucial role in the development of the female reproductive tract in mice. Deficiencies in ADAMTS18 result in abnormalities such as vaginal atresia, vaginal septum, and abnormal fusion of Mullerian ducts. The decrease in apoptosis of vaginal cells and serum estradiol levels are key factors in the development of vaginal defects in Adamts18 knockout mice.
REPRODUCTIVE BIOLOGY
(2021)
Article
Oncology
Yan Lin, Lei Wei, Beiquan Hu, Jinyan Zhang, Jiazhang Wei, Zhongrun Qian, Donghua Zou
Summary: The study revealed that RBM8A is up-regulated in GBM tissues and its higher expression is correlated with worse prognosis. RBM8A may promote GBM cell proliferation and migration by activating the Notch/STAT3 pathway, suggesting it as a potential therapeutic target for GBM treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Eline R. M. Mooren, Cindy G. J. Cleypool, Laetitia M. O. de Kort, Angelique J. Goverde, Pieter Dik
Summary: This study aimed to investigate the prevalence of congenital renal abnormalities in women with MDAs, finding a high association between MDAs and various congenital renal abnormalities. The results suggest that women with MDAs should be routinely screened for their co-occurrence, but there is still a lack of awareness about this association. Further investigation is needed to determine whether all women with congenital renal abnormalities should undergo routine screening for MDAs.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2021)
Review
Acoustics
M. A. Coelho Neto, A. Ludwin, F. Petraglia, W. P. Martins
Summary: The evidence regarding T-shaped uterus is limited and of poor quality, with unclear prevalence, etiology, and clinical relevance. There is no consensus on the definition and diagnostic methods for this condition, and expectant management is recommended until further randomized controlled trials are conducted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyrylo Pyrshev, Naghmeh Hassanzadeh Khayyat, Anna Stavniichuk, Viktor N. Tomilin, Oleg Zaika, Nirupama Ramkumar, Oleh Pochynyuk
Summary: The inhibition of ClC-K2 can be used to distinguish between A-type and B-type intercalated cells in the collecting duct and monitor changes in their functional status and abundance in response to systemic acid/base stimuli.
Article
Oncology
Rong Liang, Jinyan Zhang, Zhihui Liu, Ziyu Liu, Qian Li, Xiaoling Luo, Yongqiang Li, Jiazhou Ye, Yan Lin
Summary: RBM8A is abnormally overexpressed in hepatocellular carcinoma (HCC) and is involved in the development of drug resistance. It has the ability to regulate tumor-related signaling pathways, particularly through its interaction with histone deacetylase 9 (HDAC9). These findings suggest that RBM8A and its related pathways could serve as potential markers of oxaliplatin resistance and therapeutic targets in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Kaitlin N. Hart, William A. Stocker, Nicholas G. Nagykery, Kelly L. Walton, Craig A. Harrison, Patricia K. Donahoe, David Pepin, Thomas B. Thompson
Summary: This study elucidates the molecular mechanism of how anti-Mullerian hormone (AMH) binds to its receptor AMHR2, highlighting key interaction points that contribute to specificity and providing insights for the design of agonists, antagonists, or antibody therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
D. E. J. Waschk, A. -C. Tewes, T. Roemer, J. Hucke, K. Kapczuk, C. Schippert, P. Hillemanns, P. Wieacker, S. Ledig
Article
Developmental Biology
Jan Rehkaemper, Ann-Christin Tewes, Judit Horvath, Gerd Scherer, Peter Wieacker, Susanne Ledig
SEXUAL DEVELOPMENT
(2017)
Article
Genetics & Heredity
S. Ledig, A. C. Tewes, J. Hucke, T. Roemer, K. Kapczuk, C. Schippert, P. Hillemanns, P. Wieacker
Article
Biochemistry & Molecular Biology
Albrecht Roepke, Ann-Christin Tewes, Joerg Gromoll, Sabine Kliesch, Peter Wieacker, Frank Tuettelmann
EUROPEAN JOURNAL OF HUMAN GENETICS
(2013)
Article
Obstetrics & Gynecology
Ann-Christin Tewes, Susanne Ledig, Frank Tuettelmann, Sabine Kliesch, Peter Wieacker
FERTILITY AND STERILITY
(2014)
