Journal
BIOORGANIC CHEMISTRY
Volume 80, Issue -, Pages 555-559Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2018.06.034
Keywords
Lipase; Knoevenagel condensation; Aromatic aldehyde; Xanthone; Catalysis
Funding
- National Natural Science Foundation of China [21676143]
- key laboratory of Materials-Oriented Chemical Engineering [ZK201603]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture
- Qing Lan Project of Jiangsu Province
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Based on the screening of biocatalysts and reaction conditions including organic solvent, water content, lipase loading, reaction temperature and time, lipase TLIM exhibited the prominent promiscuity for the Knoevenagel-Michael cascade reactions of 1, 3-diketones with aromatic aldehydes to synthesize xanthone derivatives. This procedure provides satisfactory advantages such as environmental begin, simple work-up, generality, obtaining in excellent yields (80-97%), and potential for recycling of biocatalyst.
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