Review
Biochemistry & Molecular Biology
Sahar Esfandyari, Hoda Elkafas, Rishi Man Chugh, Hang-soo Park, Antonia Navarro, Ayman Al-Hendy
Summary: Cell-cell communication through exosomes plays a crucial role in female reproductive diseases, offering potential therapeutic targets and biomarkers for regulating reproductive system development and pregnancy outcomes in abnormal conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yi Luan, Pauline Xu, Seok-Yeong Yu, So-Youn Kim
Summary: The p63 transcription factor is crucial in female reproduction, serving as a genomic guardian in the ovaries and its mutations are increasingly associated with female infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Xiaobo Liu, Jiajia Li, Wenjun Wang, Xue Ren, Ji-Fan Hu
Summary: Millions of women worldwide suffer from infertility associated with gynecologic disorders. Stem cell therapy has emerged as a new therapeutic option for the treatment of female reproductive and endocrine dysfunction. This review discusses the recent development and underlying mechanisms of stem cell therapy for a variety of female reproductive diseases.
Review
Endocrinology & Metabolism
Marcelle Cedars
Summary: This article discusses the integration of anti-Mullerian hormone (AMH) into the diagnosis and treatment of infertility. AMH can be used to estimate ovarian reserve, determine the dosage of ovarian stimulation, and predict stimulation response. However, it does not reflect oocyte health or chances for pregnancy. Low AMH levels may suggest a shortened reproductive window. AMH levels need to be interpreted in the context of the endogenous endocrine environment, and there is an inverse correlation between body mass index and AMH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
Summary: Oxidative stress plays a significant role in oocyte aging, leading to a gradual decrease in oocyte quantity and quality, as well as various reproductive pathologies. Strategies to delay oocyte aging include targeting oxidative stress through autophagy antioxidant pathways and antioxidants, along with creating a hypoxic culture environment for oocytes in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Surgery
Krista Lai, Erin M. Garvey, Cristine S. Velazco, Manrit Gill, Erica M. Weidler, Kathleen van Leeuwen, Eugene S. Kim, Erika L. Rangel, Gwen M. Grimsby
Summary: This survey study compares the prevalence of pregnancy complications and infertility between female physicians and the general population. The results show that female physicians have a higher incidence of miscarriage, infertility, and preterm birth compared to the general population. Factors such as delaying pregnancy and lack of education contribute to these outcomes.
Article
Biochemistry & Molecular Biology
Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A. Flaws, Humphrey Hung-Chang Yao
Summary: The study found that overexpression of NR5A1 in female mice leads to reproductive dysfunction and metabolic imbalance, resulting in premature infertility. These results provide a new model for studying not only the molecular actions of NR5A1, but also the crosstalk between endocrine, reproductive, and metabolic systems.
Review
Plant Sciences
Kannan Maharajan, Qing Xia, Xiuying Duan, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, and has shown potential therapeutic effects in improving fertility and pregnancy rates. Clinical studies have demonstrated its curative effects on various reproductive disorders by regulating reproductive functions such as ovulation, follicle development, and hormonal balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang
Summary: Mutations in the CDC20 gene play a crucial role in oocyte maturation and fertilization, leading to various infertility phenotypes. This study expands the spectrum of known mutations in CDC20 and provides new evidence for its involvement in female infertility characterized by oocyte maturation arrest and fertilization failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giedre Skliute, Raminta Bausyte, Veronika Borutinskaite, Giedre Valiuliene, Algirdas Kaupinis, Mindaugas Valius, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The study found that menstrual blood stem cells have good proliferation and regenerative abilities, can perform decidualization through differentiation into epithelial cells, and express genes related to decidualization and angiogenesis, demonstrating the potential for treating reproductive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Hana Hasan Webair, Tengku Alina Tengku Ismail, Shaiful Bahari Ismail, Azza Jameel Khaffaji, Nik Hazlina Nik Hussain, Azidah Abdul Kadir, Rosediani Muhamad, Fatin Aina Abu Bakar, Nur Raihan Ismail, Nagwa Badri
Summary: The study developed a draft Arabic patient-centered infertility care questionnaire through an iterative process involving in-depth interviews, literature review, and expert validation, resulting in a final pool of 57 items. The questionnaire will undergo testing of its psychometric properties to prepare the final version for measuring the level of patient-centered care in health facilities.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Medicine, General & Internal
Adele Grasmane, Dmitrijs Rots, Zane Vitina, Valerija Magomedova, Linda Gailite
Summary: The study found that high-normal alleles of the FMR1 gene are associated with secondary infertility, but they did not have a significant impact on primary infertility or low-normal alleles. Further research is needed to address controversies related to the role of FMR1 genes in the development of diminished ovarian reserve.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Wei Yong, Jiajia Wang, Yan Leng, Lijie Li, Han Wang
Summary: Contemporary scientists are well aware of the increasing prevalence of obesity and its complications. Obesity is strongly associated with type 2 diabetes, hypertension, vascular disease, tumors, and reproductive disorders. It affects female reproduction by reducing fertility, increasing miscarriage rates, and affecting the success of in vitro fertilization. Moreover, obesity-induced inflammation has a chronic inflammatory response, affecting the complete process of female reproduction.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Farah Ennab, William Atiomo
Summary: Infertility is a global health issue, and its association with obesity is not well understood. Studies have found that preconception maternal weight is inversely correlated with live birth rates. However, there is insufficient evidence for the effectiveness of preconception lifestyle interventions or pharmacological interventions in obese women with infertility. This has implications for clinical practice and future research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Review
Medicine, General & Internal
Mahua Bhaduri, Ippokratis Sarris, Kate Bramham
Summary: This review summarises the current literature on infertility in women with chronic kidney disease (CKD), discussing the epidemiology, pathophysiology, investigations, and management options. The pathophysiology is multifactorial, involving disruption of hormonal axis, inflammation, oxidative stress, psychological factors, and adverse effects of medications. Early investigations in CKD patients seeking to conceive should include hormonal profiling and imaging to evaluate ovarian reserve and gynaecology pathology. Treatment options include preserving ovarian function during cyclophosphamide treatment and assisted reproductive technologies. Tailored management considering individual health, comorbidities, fertility requirements, and CKD stage is crucial. Early discussions and referral to fertility services are important. Ongoing research aims to clarify mechanisms and optimize treatment strategies for better outcomes.
