Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 28, Issue 10, Pages 1860-1863Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.04.006
Keywords
Garcinia multiflora; Guttiferae; Polyprenylated polycyclic; acylphloroglucinol; Garcimultiflorone K; Angiogenesis inhibitor
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Funding
- Ministry of Science and Technology, Taiwan [MOST 105-2320-B-010-040, MOST 106-2320-B-010-033-MY3]
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A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Gamma multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1 -3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate cancer cell line PC-3 with GI(50) values of 4.3 +/- 1.6 and 6.6 +/- 0.4 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.
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