Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 26, Issue 19, Pages 5307-5313Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2018.04.020
Keywords
Bioconjugation; Biosensors; Interfacial functionalization; Emulsions; Janus particles
Funding
- National Institutes of Health of General Medical Sciences [GM095843]
- University of Pisa
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM095843] Funding Source: NIH RePORTER
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Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates. (C) 2018 Published by Elsevier Ltd.
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