Article
Chemistry, Medicinal
Neil K. Viswanathan, Michael E. Chirgwin, Julia Gibbs, Brianna N. Kalaj, Sierra Durham, Jennifer Tran, Maximillian Gomez, Horacio Lazaro, Ming Chen, Christopher R. Mansfield, Emily R. Derbyshire, Scott Eagon
Summary: A series of & beta;-carbolines based on harmine were synthesized and tested for antimalarial activity and toxicity. Some of these compounds showed promising bioactivity, offering a new therapeutic option with a unique mode of action compared to current clinical treatments.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Food Science & Technology
Abir Ben Bacha, Norah Al-Orf, Mona Alonazi, Ramesa Shafi Bhat, Afaf El-Ansary
Summary: This study demonstrates that probiotics can reduce apoptosis and neuroinflammation induced by propionic acid (PPA) by modulating gut function. In a hamster model, probiotics significantly decreased levels of apoptotic markers and inflammation markers, providing protection against brain damage.
FOOD SCIENCE & NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Anesthesiology
Yaomin Wang, Scott A. Scarneo, Shin Hyung Kim, Xin Zhang, Jiegen Chen, Kelly W. Yang, Philip Hughes, Timothy Haystead, Andrea G. Nackley
Summary: Through a study on a mouse model, we found that the expression of eHsp90 on nociceptors increases during inflammation, and inhibiting eHsp90 can alleviate pain and inflammatory response. This finding provides a new approach for developing gender-tailored treatments for inflammatory pain.
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Article
Immunology
Runjing Cao, Zihao Li, Chuyu Wu, Senlin Ji, Yahui Li, Xiang Cao, Xiaohong Dong, Meiling Jiang, Tao Pang, Chenhui Wang, Jingwei Li, Yun Xu, Cun-Jin Zhang
Summary: Pyroptosis is a key inflammatory form of cell death that plays an important role in the progression of many inflammatory diseases. In this study, we conducted a screening of compounds based on in silico docking and found that C202-2729 could significantly attenuate the severity of experimental autoimmune encephalomyelitis (EAE) and showed comparable effects to the clinical drug teriflunomide. Furthermore, we found that C202-2729 did not affect GSDMD cleavage, upstream inflammasome activation, pore formation, and mature IL-1b release in mouse macrophages. These findings suggest that C202-2729 may have potential for translational application in GSDMD-associated inflammatory diseases.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Hui-Ju Tseng, Suddhasatwa Banerjee, Bin Qian, Mei-Jung Lai, Tung-Yun Wu, Tsung- Hsu, Tony Eight Lin, Kai Cheng Hsu, Kuo-Hsiang Chuang, Jing-Ping Liou, Jean C. Shih
Summary: In this study, MAO A/HSP90 dual inhibitors were synthesized and found to be effective in inhibiting the growth of GBM and other cancers. These inhibitors showed activity against MAO A, HSP90 binding, and growth of both TMZ-sensitive and -resistant GBM cells. Additionally, they exhibited potential as immune checkpoint inhibitors by reducing IFN-gamma induced PD-L1 expression.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ho Jin Lee, Hye-Young Min, Young-Sik Yong, Jihyae Ann, Cong Truong Nguyen, Minh Thanh La, Seung Yeob Hyun, Huong Thuy Le, Hyewon Kim, Hyukjin Kwon, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ho-Young Lee
Summary: This study revealed that Hsp90 inhibitors that block the N-terminal ATP-binding pocket activate STAT3, leading to the transcriptional upregulation of Wnt ligands and promoting cell survival in NSCLC. NCT-80 effectively reduced NSCLC cell viability, migration, and CSC-like phenotypes, and inhibited the growth of patient-derived xenograft tumors.
Review
Infectious Diseases
Juan M. Cantet, Zhantao Yu, Agustin G. Rius
Summary: Animals exposed to elevated ambient temperature experience physiological changes such as redistribution of blood and decreased blood flow to splanchnic tissues, leading to metabolic adaptations and gut dysfunction, ultimately activating a systemic inflammatory response.
Article
Multidisciplinary Sciences
Nasrin Talkhi, Mehdi Jabbari Nooghabi, Habibollah Esmaily, Saba Maleki, Mojtaba Hajipoor, Gordon. A. Ferns, Majid Ghayour-Mobarhan
Summary: This study used ensemble machine learning methods to determine the factors associated with serum anti-HSP27 antibody titers and demonstrated the magnitude and direction of the predictors using PFI and SHAP methods. The LightGBM model revealed several factors associated with anti-HSP27, including pro-oxidant-antioxidant balance, physical activity level, and various other factors. These findings improve our understanding of factors influencing anti-HSP27 antibody titers and their potential role in disease development.
SCIENTIFIC REPORTS
(2023)
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Soyema Khatun, Taewan Kim, Md. Mahi Imam Mollah
Summary: This study investigated the changes in functional components of soybeans under different temperature and duration conditions. The results showed that heat shock at 60 degrees C for 2 h increased polyphenols, antioxidants, and aglycon isoflavones in soybeans, resulting in increased anti-inflammatory and anti-obesity activity.
Article
Biochemistry & Molecular Biology
Tanya Ju-Ngam, Nichanun McMillan, Mamoru Yoshimizu, Hisae Kasai, Ratree Wongpanya, Prapansak Srisapoome
Summary: This research conducted molecular characterization and biofunctional analyses of Hsp40 and Hsp90 genes in giant river prawns under various stress conditions. The highest similarity scores of these genes were found with crustaceans. Expression patterns of Mr-hsp40 and Mr-hsp90 were different under Aeromonas hydrophila challenge and heat-cold shock conditions, highlighting their significant roles in stress responses.
Article
Plant Sciences
Yunxie Wei, Hongqiu Zeng, Wen Liu, Xiao Cheng, Binbin Zhu, Jingru Guo, Haitao Shi
Summary: This study systematically analyzed the correlation between HSP90 and autophagy signaling in cassava, and investigated their effects on plant disease response and underlying mechanisms through functional genomics and genetic phenotype assay. The study found that the potential MeHSP90.9-MeSGT1-MeRAR1 chaperone complex interacts with MeATGs and triggers autophagy signaling, enhancing disease resistance to cassava bacterial blight.
Article
Immunology
Jeonghyun Lee, Hyosung Park, Jiwon Lim, Hyung-Seung Jin, Yoon Park, Yu-Jin Jung, Hyun-Jeong Ko, Sung-Il Yoon, Geun-Shik Lee, Pyeung-Hyeun Kim, Sun Shim Choi, Changchun Xiao, Seung Goo Kang
Summary: This study reveals the crucial role of GSK3 in determining the fate of GC B cells towards plasma cell formation, by inducing changes in transcription factors required for plasma cell differentiation. This finding highlights the upstream master regulator responsible for interpreting external cues and mediating the formation of plasma cells in GC B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Young-In Kim, Eun-Je Yi, Young-Dae Kim, A. Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun-Jeong Ko, Jae-Hee Cheon, Yong Rae Hong, Sun-Young Chang
Summary: The novel drug CG-598 showed significant anti-inflammatory effects in an experimental murine colitis model, enhancing barrier function, reducing inflammatory lesions, and decreasing the expression of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hee-Sung Chae, Hyun Ji Kim, Hyun-Jeong Ko, Chang Hoon Lee, Young Hee Choi, Young-Won Chin
Article
Biochemistry & Molecular Biology
Jae-Hee Ahn, Byung-Hyun Lee, Seong-Eun Kim, Bo-Eun Kwon, Hyunjin Jeong, Jong Rip Choi, Min Jung Kim, Yong Park, Byung Soo Kim, Dae Hee Kim, Hyun-Jeong Ko
Summary: Multiple myeloma is a malignant cancer of plasma cells that remains incurable despite recent advancements in treatment. This study suggests that targeting the PD-L1 molecule with an anti-PD-L1 antibody could be a promising strategy for treating multiple myeloma, as it induces antibody-dependent cellular cytotoxicity against myeloma cells.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Virology
Seong-Ryeol Kim, Myeong-Seon Jeong, Seo-Hyeon Mun, Jaewon Cho, Min-Duk Seo, Hyoungsu Kim, Jooeun Lee, Jae-Hyoung Song, Hyun-Jeong Ko
Summary: Chrysin demonstrates potent antiviral activity against A/PR/8 influenza virus by inhibiting viral infection at the early stages of the replication cycle, mainly through activation of mTOR and suppression of autophagy.
Article
Biochemistry & Molecular Biology
Jaewon Cho, Nara Tae, Jae-Hee Ahn, Sun-Young Chang, Hyun-Jeong Ko, Dae Hee Kim
Summary: Chimeric antigen receptor T (CAR-T) cell therapy has shown promising results in treating blood cancer with high overall response rate. However, it has limitations in treating solid tumors and exhibits side effects. Bispecific antibodies have the potential to engage immune cells to target cancer cells and show effective tumor killing activity in vitro and in vivo. Engaging activated T cells with cancer cells using bispecific antibodies could be a novel next generation therapy that inhibits PD-L1 and increases infiltration of activated T cells in tumor site.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Chemistry, Applied
Minyeong Kim, Seong-Ryeol Kim, Jiye Park, Seo-Hyeon Mun, Myounghai Kwak, Hyun-Jeong Ko, Seung-Hoon Baek
Summary: This study aimed to investigate the structure and anti-enterovirus 71 (EV71) effects of polysaccharides extracted from the roots of Sanguisorba officinalis (SO), traditionally used for infectious diseases. The results showed that the purified polysaccharide (S-a3) significantly inhibited cell death and viral gene expression in EV71-infected cells, and alleviated EV71-induced symptoms in a mouse model. The effective dose of S-a3 was non-toxic. This study demonstrates that polysaccharides from SO can be a safe and effective treatment for EV71 infection.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dong-Gyun Hong, Ga Yeon Song, Cheol Bin Eom, Jae-Hee Ahn, Sun Myoung Kim, Aeri Shim, Yong-Hyun Han, Yoon-Seok Roh, Chang Yeob Han, Eun Ju Bae, Hyun-Jeong Ko, Yoon Mee Yang
Summary: This study reveals the increased expression of ERdj5 in alcoholic liver disease patients and mice. Mice lacking Dnajc10 are more susceptible to alcohol-induced liver injury and hepatic steatosis. Additionally, Dnajc10 depletion worsens oxidative stress and decreases Nrf2 pathway and glutathione contents, providing protection against liver damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Young-Saeng Jang, Seok-Won Yang, Tae-Gyu Kim, Ha-Eon Song, Sunhee Park, Eun Hye Lee, Seung-Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Geun-Shik Lee, Seok-Rae Park, Su Ryeon Seo, Pyeung-Hyeun Kim
Summary: The lactoferrin chimera (LFch) enhances TGF beta 1-induced Foxp3(+) Treg differentiation by diminishing TCR/CD28 signal intensity.
Article
Biochemistry & Molecular Biology
Taewoo Kim, Hyun Su Kim, Jaebong Jang, Dong-Jun Kim, Jongkook Lee, Dongjoo Lee, Seok-Ho Kim
Summary: This paper presents a concise and scalable method for synthesizing the phytoestrogen 7,2'-dihydroxy-4',5'-dimethoxyisoflavanone. The key steps of the synthesis include the construction of the deoxybenzoin unit and the efficient synthesis of the isoflavanone architecture.
Article
Immunology
Eun-Je Yi, Young -In Kim, Jae-Hyoung Song, Hyun-Jeong Ko, Sun -Young Chang
Summary: Mucosal surfaces play a vital role in protecting the body from infection, and mucosal vaccine delivery is crucial for establishing pathogen-specific mucosal immunity. This study investigates the intranasal administration of curdlan and antigen to induce mucosal immune responses and protect against viral infections. The results show that co-administration of curdlan and antigen increases specific antibodies and induces the differentiation of antigen-specific cells. Furthermore, the combination of curdlan and VP1 provides effective protection against enterovirus infection and reduces tissue damage by promoting Th17 responses.
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Suhyun Kim, Eun-Hye Hong, Cheol-Ki Lee, Yiseul Ryu, Hyunjin Jeong, Seungnyeong Heo, Joong-Jae Lee, Hyun-Jeong Ko
Summary: IL-22, a pleiotropic cytokine, shows potential in attenuating and treating colitis. The effective production and purification of recombinant mIL-22 in bacteria demonstrate its ability to ameliorate acute colitis and suppress pro-inflammatory cytokine production.
Article
Immunology
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Myeong Seon Jeong, Yoon Mee Yang, Jaewon Cho, Jae-Hyeon Jeong, Younggil Cha, Kil-Nam Kim, Hong Pyo Kim, Sun-Young Chang, Hyun-Jeong Ko
Summary: This study investigated the association between lipid metabolism and exacerbation of CVB3 pathology using a high-fat diet-induced obese mouse model. The results showed that lipotoxicity-induced inflammation in adipose tissue of obese mice led to increased replication of CVB3 and mortality. Additionally, inhibition of lipid-induced mtROS decreased viral replication. HFD-fed mice were more susceptible to CVB3-induced mortality, but this was ameliorated by administration of the mtROS inhibitor, MitoQ. These findings suggest that mtROS inhibitors could be potential treatments for CVB3 infection.
Article
Biochemistry & Molecular Biology
Hyo-Ji Lee, Wan-Gi Hong, Yunseo Woo, Jae-Hee Ahn, Hyun-Jeong Ko, Hyeran Kim, Sungjin Moon, Tae-Wook Hahn, Young Mee Jung, Dong-Keun Song, Yu-Jin Jung
MOLECULES AND CELLS
(2020)
