Review
Biochemistry & Molecular Biology
Cristobal avila, Jose Ignacio Vinay, Marzia Arese, Luciano Saso, Ramon Rodrigo
Summary: Infertility is a common condition that affects a significant percentage of couples worldwide, with male infertility being a prominent cause. Oxidative stress has been increasingly recognized as a key factor in male infertility, but effective antioxidant interventions have not yet been established.
Article
Biology
Peiman Zandi, Ewald Schnug
Summary: Environmental changes caused by anthropogenic activities have a significant impact on plants, leading to the generation of reactive oxygen species (ROS) and ultimately oxidative stress. Plants have developed defensive mechanisms, including enzymatic and non-enzymatic antioxidants, to scavenge excess ROS and maintain cellular redox homeostasis. Additionally, plant-microbe interactions have been found to improve immune systems in plants under stress. Understanding and studying these antioxidant systems and beneficial microbiome interactions in plants are important for plant survival and productivity.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Pavel Kerchev, Frank Van Breusegem
Summary: Reactive oxygen species (ROS), once considered harmful metabolic byproducts, are now seen as integral to cellular programs, activating signaling pathways that regulate plant growth, development, and defense. Adverse environmental conditions can lead to excessive ROS levels, causing oxidative stress and negative impacts on cellular components. Research efforts have focused on enhancing antioxidant mechanisms to improve oxidative stress resilience in both model and crop species.
Review
Pharmacology & Pharmacy
Zsolt Kopa, Marton Keszthelyi, Nikolaos Sofikitis
Summary: Antioxidant supplementation may protect sperms against oxidative stress, but excessive exposure can lead to reductive stress, affecting sperm function and embryo development. Studies on antioxidant treatment in male infertility reported improvements in sperm parameters, but also highlighted the uncertainties and biases in the results. There is a need for further research on the balance between oxidant and antioxidant systems to better understand their impact on fertility and potential health risks.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Evangelos N. Symeonidis, Evangelini Evgeni, Vasileios Palapelas, Dimitra Koumasi, Nikolaos Pyrgidis, Ioannis Sokolakis, Georgios Hatzichristodoulou, Chara Tsiampali, Ioannis Mykoniatis, Athanasios Zachariou, Nikolaos Sofikitis, Ares Kaltsas, Fotios Dimitriadis
Summary: Male infertility is a common medical condition affecting approximately 15% of couples globally, with an estimated 190 million people struggling with it. Urologists face a wide range of male infertility conditions, from typical cases to more complex ones, with oxidative stress being a critical component entailing an imbalance between ROS and antioxidants. The antioxidant paradox poses one of the biggest challenges in andrology, with the emergence of new tools like the MiOXSYS (R) assay offering a quantification of OS and potential solutions for maintaining redox balance.
Review
Biochemistry & Molecular Biology
Thomas Kalfas, Aris Kaltsas, Evangelos N. Symeonidis, Asterios Symeonidis, Athanasios Zikopoulos, Efthalia Moustakli, Chara Tsiampali, Georgios Tsampoukas, Natalia Palapela, Athanasios Zachariou, Nikolaos Sofikitis, Fotios Dimitriadis
Summary: This study evaluates the effects of COVID-19 on testicular function and the potential role of antioxidants. Although the virus is rarely detectable in sperm and testicular tissue, semen quality and hormonal balance are affected, and testicular pathology in deceased patients shows defects in spermatogenesis, vascular changes, and inflammation. Limited research makes it uncertain whether antioxidants can improve sperm quality after infection.
Article
Biochemistry & Molecular Biology
Emily P. P. Evans, Jorien T. M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G. J. M. Arts, Romana Schirhagl, Astrid E. P. Cantineau
Summary: Currently, 15% of couples are suffering from infertility, with 45-50% of cases attributed to male factors. Free radicals or reactive oxygen species (ROS) play a key role in the fertility process, while also serving important functions in sperm maturation. These ROS are influenced by lifestyle, age, and disease.
Review
Andrology
Cayde Ritchie, Edmund Y. Ko
Summary: The impact of reactive oxygen species on male fertility is determined by the delicate balance between oxidative stress and antioxidant capacity. Uninhibited reactive oxygen species can lead to damage to sperm, potentially causing male factor infertility. Research has shown that oxidative stress may affect male fertility through various pathological pathways, providing new directions for studying and predicting reproductive success.
Review
Andrology
Sajal Gupta, Renata Finelli, Ashok Agarwal, Ralf Henkel
Summary: Oxidative stress is prevented by antioxidants, which are crucial for sperm health. Total antioxidant capacity (TAC) can aid in diagnosing male infertility, as infertile patients tend to have lower TAC levels. There is a positive correlation between TAC and seminal parameters, and evaluating TAC along with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may improve the accuracy of diagnosing male infertility.
Article
Biochemistry & Molecular Biology
Maria Robles, Rafael Torronteras, Carol Ostojic, Cinta Oria, Maria Cuaresma, Ines Garbayo, Francisco Navarro, Carlos Vilchez
Summary: This study investigated the physiological and biochemical responses of Coccomyxa onubensis to Fe(III)-induced stress. The results showed that moderate levels of Fe(III) improved the growth and photosynthetic viability of C. onubensis, as well as triggered antioxidant responses. The findings suggest that C. onubensis has a notable antioxidant capacity, making it suitable for producing cell extracts with potential anti-inflammatory activity.
Review
Biochemistry & Molecular Biology
Zhen Zeng, Christoph Centner, Albert Gollhofer, Daniel Koenig
Summary: Whole dietary strategies rich in antioxidants have gained attention for their potential to alleviate exercise-induced oxidative stress, with most studies showing favorable effects. However, research on the effects of such strategies on oxidative stress is still limited, and further systematically designed studies are needed to strengthen the evidence.
Review
Biochemistry & Molecular Biology
Maochao Luo, Li Zhou, Zhao Huang, Bowen Li, Edouard C. Nice, Jia Xu, Canhua Huang
Summary: Cancer is associated with oxidative stress, and targeting this imbalance between reactive oxygen species (ROS) and antioxidants may have therapeutic potential. However, the clinical efficacy of antioxidants in cancer treatment remains uncertain. This review discusses the rationale and recent advances in antioxidant therapy for cancer, as well as potential strategies for improving its effectiveness.
Review
Biochemistry & Molecular Biology
Elena-Codruta Dobrica, Matei-Alexandru Cozma, Mihnea-Alexandru Gaman, Vlad-Mihai Voiculescu, Amelia Maria Gaman
Summary: Psoriasis is associated with oxidative stress, and the duration and severity of the disease are positively correlated with the concentration of oxidative stress markers. The crosstalk between psoriasis and oxidative stress is influenced by polymorphisms in genes related to redox balance. Further research should focus on evaluating oxidative stress biomarkers and studying the polymorphisms in genes regulating redox balance in psoriasis patients, as well as translating these findings into the management of psoriasis and understanding its pathogenesis.
Review
Pharmacology & Pharmacy
Fotios Dimitriadis, Evangelos N. Symeonidis, Panagiota Tsounapi, Aris Kaltsas, Georgios Hatzichristodoulou, Ioannis Sokolakis, Athanasios Zachariou, Atsushi Takenaka, Nikolaos Sofikitis
Summary: Although antioxidants have emerged as a promising solution for male infertility induced by oxidative stress, the excessive use of these compounds may be harmful. Further elaborate studies are needed in the future to explore the effects of antioxidants on semen parameters and fertility potential.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Engineering, Multidisciplinary
Muhammad Nadeem, Imran Siddique, Rifaqat Ali, Nawa Alshammari, Raja Noshad Jamil, Nawaf Hamadneh, Ilyas Khan, Mulugeta Andualem
Summary: This work investigates fundamental flow problems of a third-grade non-Newtonian fluid in a fuzzy environment. The governing nonlinear DEs are transformed into FDEs using MFs and solved using the ADM. The findings are consistent with previous results and the effect of alpha-cut and engineering constants on fuzzy velocity profile is analyzed graphically and numerically.
MATHEMATICAL PROBLEMS IN ENGINEERING
(2022)
Review
Urology & Nephrology
Muhammad Naveed, Changxing Li, Awais Ullah Ihsan, Muhammad Shumzaid, Asghar Ali Kamboh, Ali Asghar Mirjat, Muhammad Saeed, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Sobia Noreen, Asadullah Madni, Xiaohui Zhou
Summary: The assessment and management of urologic chronic pelvic pain syndrome (UCPPS) is controversial due to the lack of reliable tools for evaluating symptoms and quality of life impact. The etiology is multifactorial, and treatment options are uncertain. The immune system plays an important role in the disease. The UPOINT system can guide treatment and improve symptoms.
Article
Mathematics, Applied
Liaquat Ali Lund, Abderrahim Wakif, Zurni Omar, Ilyas Khan, Isaac Lare Animasaun
Summary: This report investigates the influence of thermal radiation and viscous dissipation on the motion of hybrid nanofluid over a moving surface. The study finds that thermal radiation parameter enhances heat transfer rate and increases temperature, and two solution branches are observed, with the upper branch being stable.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2023)
Article
Thermodynamics
Lipika Panigrahi, J. P. Panda, Ilyas Khan
Summary: This study focuses on analyzing the entropy generation and 2-dimensional unsteady stagnation flow with suction/injection constraint present in the boundary. The model also incorporates the induced magnetic field formed by the motion of conductive fluid. The time-dependent partial differential equations are transformed into non-linear ordinary differential equations using suitable similarity variables. Numerical solutions are obtained using shooting technique and the results are presented and discussed through graphs and tables.
NUMERICAL HEAT TRANSFER PART B-FUNDAMENTALS
(2022)
Article
Neurosciences
Rana Muhammad Shoaib, Muhammad Zaeem Ahsan, Usman Akhtar, Khalil Ali Ahmad, Usman Ali, Men-Yan Deng, Xin-Yan Li, Yong-Xiang Wang
Summary: Panax notoginseng is commonly used to alleviate chronic pain and is available in China as a nonprescription drug. Scientific evidence is needed to demonstrate its pain-relieving effects, effective ingredients, and mechanism of action.
NEUROSCIENCE RESEARCH
(2023)
Article
Physics, Multidisciplinary
Muhammad Zafarullah, Ilyas Khan, Aneesa, Najeeb Alam Khan
Summary: The aim of this research is to investigate the behavior of the fractionalized Oldroyd-B fluid with the influence of MHD effect, enclosed by two endless uniaxial circular cylinders, using Laplace transform with Antangano Baleanu fractional operator and finite Hankel transform. Both cylinders are moving together about their same axis, with the inner and outer cylinders starting from a resting state and having rotational and translational time-dependent velocities. Analytical solutions for flow rate and tangential stress are obtained using integral and series patterns in the form of the generalized function M, which satisfy all imposed boundary conditions. Comparable solutions for ordinary Oldroyd-B, Maxwell, second grade, and Newtonian fluids can be easily achieved as special cases of the generalized results. The graphical illustration provides predictions on the impact of relaxation time and non-integer order fractional material on fluid flow, as well as comparisons between the equations.
WAVES IN RANDOM AND COMPLEX MEDIA
(2023)
Review
Rehabilitation
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed
Summary: Obesity is a severe health concern that is associated with heart failure and cardiovascular disease. It is caused by a metabolic imbalance where more calories are consumed than burnt. Obesity has adverse impacts on the cardiovascular system, including inflammation, atherosclerosis, and high blood pressure. It is also a known risk factor for various diseases.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2023)
Article
Mathematics, Interdisciplinary Applications
Mohd Anul Haq, Ilyas Khan, Ahsan Ahmed, Sayed M. Eldin, Ali Alshehri, Nivin A. Ghamry
Summary: In this paper, a novel Deep Convolutional Neural Network for Brain Tumor (DCNNBT) is proposed for the detection and classification of brain tumors, emphasizing the importance of early diagnosis for effective treatment and improved patient survival rates.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Article
Mathematics, Interdisciplinary Applications
Ghulam Bary, Waqar Ahmed, Riaz Ahmad, Sayed m. Eldin, Ilyas Khan, Duohui Huang
Summary: This paper investigates the influence of temperature and momentum-dependent coherence-chaos radiations on particle excretion from a fluid with quantum supremacy. The study provides a comprehensive analysis of the fluid in the context of quantum interference for partially chaotic systems and presents novel findings on chaos synchronization of identical bosons in the extending source. The results demonstrate the significant impact of coherence on chaotic production and describe the temperature profile and density equations of the fluid.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Article
Mathematics, Interdisciplinary Applications
Amjad Hussain, Adil Jhangeer, Muhammad khubaib Zia, Ilyas Khan, Abdul hamid Ganie, Sayed m. Eldin
Summary: In this study, the nonlinear generalized Camassa-Holm Kadomtsev-Petviashvili equation in (1 + n) dimensions is investigated using Lie theory. Lie point symmetries and conservation laws of the equation are computed, and a wide range of solitonic structures are obtained using an extended algebraic approach.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Mathematics, Interdisciplinary Applications
Ghulam Bary, Waqar Ahmed, Riaz Ahmad, Abha Singh, Sayed M. Eldin, Duohui Huang, Ilyas Khan
Summary: In this paper, the dynamics of quantum correlations in an isolated physical quantum influenced by intrinsic coherence are explored. The amount of coherent-chaotic fractions and specific correlations in the hybrid system are characterized using the granular model and spherical droplets. The effect of coherence on the evolution of these correlations in engineering applications is examined, and the behavior of multiparticle correlations in relation to system parameters and coherence rate is analyzed in detail. The study found that correlations with genuine interferences exhibit slight asymmetry and that genuine correlations are more meaningful than primary interference. Furthermore, the robustness of quantum correlations can be modulated by adjusting coherent rate, source physical properties, and initial conditions.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Article
Engineering, Multidisciplinary
Taza Gul, Sayer Obaid Alharbi, Ilyas Khan, Mohd Shakir Khan, Saleh Alzahrani
Summary: In this study, the stagnation point flow model is used to evaluate the energy transient across the nanofluid through comparative analysis. The slip surface is considered in the momentum equation to assess lubrication. A specific thermophysical model based on thermal conductivity and viscosity, with slip boundary conditions, is used. The modeled equations are processed using the Numerical Runge Kutta (RK-4) procedure, and the accuracy is checked using the control volume finite element method (CVFEM). The results are validated by prior studies and demonstrate a decent level of coherence.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Engineering, Multidisciplinary
Waqas Ali, Farhad Ali, Ata Ur Rahman, Ilyas Khan
Summary: The goal of this paper is to create a novel model for the two-dimensional flow of a second-grade fluid and the transfer of heat due to free convection. The model is developed in fractional form using the Caputo-Fabrizio fractional derivative approach. Exact solutions for fluid velocity and temperature are obtained analytically and simplified in limiting cases. Numerical results demonstrate the significant influence of embedded flow parameters on temperature and velocity profiles.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Medicine, General & Internal
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed, Faisal Siddique, Muhammad Naveed, SaifUr Rehman
Summary: This study explores the association between increased susceptibility and severity in hypertensive COVID-19 patients. The findings suggest that certain SNPs in the ACE2 gene may contribute to the severity of COVID-19 in individuals with hypertension.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
