Article
Biochemistry & Molecular Biology
Daniela Balderas-Cordero, Octavio Canales-Alvarez, Roberto Sanchez-Sanchez, Alejandro Cabrera-Wrooman, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy
Summary: This study evaluated the wound-healing effect of ChEEP and found that it can promote wound contraction, reduce healing time, increase wound tensile strength, and promote collagen formation. It is the first time that the wound-healing activity of a Mexican propolis has been evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Lin, Tao Fu, Yuqing Lei, Jiajia Xu, Sa Wang, Fuming He, Zhijian Xie, Ling Zhang
Summary: This study developed a new antibacterial hydrogel with excellent antimicrobial activity, histocompatibility, and wound healing potential. The hydrogel released antibacterial peptides to inhibit bacterial biofilm formation and regulate inflammatory responses, as well as promote angiogenesis, thereby aiding in the rapid healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Keke Wu, Meimei Fu, Yitao Zhao, Ethan Gerhard, Yue Li, Jian Yang, Jinshan Guo
Summary: This study developed a multifunctional bioadhesive made from the natural polyphenolic compound tannic acid, which possesses antioxidant, anti-inflammatory, and antimicrobial properties. The bioadhesive showed favorable biocompatibility and mechanical strength, and it promoted wound closure and scarless healing.
BIOACTIVE MATERIALS
(2023)
Article
Plant Sciences
Mehmet Evren Okur, Ayse Esra Karadag, Yagmur Ozhan, Hande Sipahi, Sule Ayla, Benay Daylan, Suekran Kultur, Betuel Demirci, Fatih Demirci
Summary: The study demonstrates the antioxidant and anti-inflammatory properties of Phlomis rigida, as well as its positive effects on wound healing through both in vitro and in vivo experiments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Polymer Science
Harshad S. Kapare, Prabhanjan S. Giram, Sadhana S. Raut, Hemant K. Gaikwad, Ana Claudia Paiva-Santos
Summary: Flavonoids and polyphenolic compounds found in propolis, a natural bee product, play a crucial role in wound healing. This study aimed to develop and characterize a propolis-based hydrogel composition with wound healing potential. The formulation was analyzed for its phytochemical content, pH, viscosity, and in vitro release. Results from burn and excision wound healing models demonstrated the efficacy of the propolis hydrogel in promoting wound contraction and re-epithelialization, comparable to the standard povidone iodine ointment. This formulation shows promise for further clinical research on wound healing.
Review
Oncology
Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo, Yong Xu, Wei Qian
Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Medicinal
Christian Oktavianus Manginstar, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, Sofia Safitri Hessel
Summary: This literature review provides an overview of propolis' mechanisms of action, wound-healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising candidate for managing skin burn injuries. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages.
PHYTOTHERAPY RESEARCH
(2023)
Review
Dermatology
Julia Carnelos Machado Velho, Thais Amaral Franca, Maria Jose Malagutti-Ferreira, Edilson Rodrigues Albuquerque, Francislaine Aparecida dos Reis Livero, Murilo Racy Soares, Ademilson Espencer Egea Soares, Joao Tadeu Ribeiro-Paes
Summary: Propolis, a natural resin produced by bees, has anti-inflammatory and antibiotic properties and promotes skin regeneration. It has shown potential as a therapeutic agent for treating skin ulcers.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Filipe Oliveira, Eduardo Silva, Ana Matias, Joana M. Silva, Rui L. Reis, Ana Rita C. Duarte
Summary: Effective antimicrobial treatment is a critical need, and this study presents a strategy using deep eutectic systems (DES) to address this need. The natural deep eutectic systems (NADES) based on menthol and saturated free fatty acids (FFA) exhibited effective antimicrobial properties against various microorganisms. Furthermore, these NADES also showed potential in wound healing by preventing microbial invasion, promoting epidermis repair, and reducing cell stress and inflammation.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen
Summary: Emodin can improve diabetic wound healing by promoting extracellular matrix synthesis and granulation tissue formation, and promote the conversion of M1-like macrophages to M2-like macrophages by down-regulating the NF-xB signaling pathway. This study identified potential targets of emodin and revealed its role in fibroblast proliferation and ECM formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qianmin Ou, Shaohan Zhang, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu, Zeyuan Cao, Jun Wu, Yan Wang
Summary: The hydrogel wound dressings developed by incorporating PUE or FA via PDA nanoparticles show improved enzyme activity, reduced ROS and malondialdehyde levels, promoting wound healing and tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Paulo R. Gabbai-Armelin, Luciana S. Sales, Tulio Morandin Ferrisse, Analu Barros De Oliveira, Juliana R. De Oliveira, Elisa M. A. Giro, Fernanda L. Brighenti
Summary: Thymol has antibacterial, antioxidant, anti-inflammatory, and wound healing properties. In vitro and in vivo studies have shown its effectiveness as an anti-inflammatory agent. However, there are biases in the studies, and more research is needed to understand the dose-response relationship and mechanism of action of thymol as a healing agent.
PHYTOTHERAPY RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Limberg Jaldin-Crespo, Nataly Silva, Jessica Martinez
Summary: This article summarizes the latest therapies for wound healing based on bionanomaterials assisted by honey and propolis, emphasizing their anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Nanomaterials enable targeted and continuous delivery at the site of the wound, avoiding systemic adverse effects.
Article
Chemistry, Applied
Guofeng Wu, Fenbo Ma, Yizhebang Xue, Ying Peng, Liqiu Hu, Xiaowo Kang, Qili Sun, Dong Fang Ouyang, Bin Tang, Lijun Lin
Summary: A chondroitin sulfate zinc (CSZn) complex synthesized using ion-exchange method has shown potential in antibacterial and wound healing applications. The CSZn exhibited inhibitory effects on Escherichia coli and Staphylococcus aureus growth and promoted fibroblast growth and wound healing at specific concentrations.
CARBOHYDRATE POLYMERS
(2022)
Article
Cell Biology
Sonia Sahvieh, Ahmad Oryan, Shadi Hassanajili, Amir Kamali
Summary: The study found that stem cell-loaded PLA/PCL/HA scaffolds showed better results in bone healing, assisting in bone tissue regeneration and healing. The experimental results demonstrated significant improvements in biomechanics, immunohistochemistry, and radiological evaluations in the BMSCs-loaded scaffold group, indicating higher levels of bone regeneration.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell & Tissue Engineering
Ahmad Oryan, Shadi Hassanajili, Sonia Sahvieh
Summary: This study tested the effects of a scaffold made of different materials on the regeneration of critical bone defects in rats, finding that the cell-seeded scaffold group showed significantly better regeneration outcomes compared to the untreated group. Additionally, the cell-seeded scaffold group and autograft group demonstrated comparable results on day 80 post-treatment.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Retraction
Cell Biology
Ahmad Oryan, Mohamadreza Baghaban Eslaminejad, Amir Kamali, Samaneh Hosseini, Ali Moshiri, Hossein Baharvand
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Sogand Sasan Moghadam, Maryam Ghahramani, Kazem Khoshaman, Ahmad Oryan, Ali Akbar Moosavi-Movahedi, Boris Kurganov, Reza Yousefi
Summary: This study evaluated the impact of peroxynitrite (PON) and methylglyoxal (MGO) on alpha A-crystallin (alpha A-Cry) and found that the reaction of these compounds led to the formation of new chromophores, changes in protein structure, reduction in oligomer size, and increased chaperone activity of alpha A-Cry. Ascorbic acid and glutathione were able to reverse these effects. The results suggest that the lens antioxidant defense system, particularly glutathione, can provide strong protection against diabetic cataract.
BIOCHEMISTRY-MOSCOW
(2022)
Review
Cell Biology
Ahmad Oryan, Effat Alemzadeh, Esmat Alemzadeh, Maryam Barghi, Mohammad Zarei, Hamid Salehiniya
Summary: Adipose stem cell therapy can enhance the healing rate of burn wounds, especially when combined with hydrogels to significantly increase the viability of adipose stem cells. However, more clinical studies are needed to further explore the role of adipose stem cells in burn wound healing.
CELL AND TISSUE BANKING
(2022)
Article
Immunology
Ahmad Oryan, Hassan Sharifi Yazdi, Soodeh Alidadi, Sedigheh Doostmohammadi
Summary: GyrB PCR-RFLP can be used for diagnosing and detecting bovine and human tuberculosis. It is an accurate and reliable method for identifying the species of Mycobacterium tuberculosis complex (MBTC) and should be considered in tuberculosis control strategies, particularly the isolation of M. bovis from human specimens.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Azadeh Moradi Pirbaluty, Hossein Mehrban, Saeid Kadkhodaei, Rudabeh Ravash, Ahmad Oryan, Mostafa Ghaderi-Zefrehei, Jacqueline Smith
Summary: This bioinformatics study analyzed the transcriptome of chickens after influenza A virus challenge to explore the host expression response. The study identified different gene importance in lowly and highly pathogenic avian influenza infections, which can provide a basis for future development of treatments and preventions against avian influenza in chickens.
Article
Agriculture, Dairy & Animal Science
Zahra Hasanpour, Mousa Zarrin, Ahmad Oryan, Mostafa Mohaghegh-Dolatabad, Amir Ahmadpour
Summary: This study aims to validate the impact of feed restriction and the transition period on hepatic genes related to fat metabolism in fat-tailed sheep. The results show that feed restriction does not affect the mRNA abundance of the target genes during both pre- and post-partum periods. However, parturition suppresses the mRNA abundance of these genes. Fat-tailed sheep are well adapted to feed scarcity and have a higher capacity for fat mobilization during negative energy balance.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Tropical Medicine
Ahmad Oryan, Effat Bemani, Somayeh Bahrami
Summary: Objective of this study was to evaluate the in vitro and in vivo efficacy of quercetin against Leishmania major, as well as its immunomodulatory and anti-oxidative activity. The results showed that quercetin exhibited anti-leishmanial activity, immunomodulatory, anti-oxidative, and anti-inflammatory effects. Therefore, it has the potential to be further explored as an effective drug for treating leishmaniasis.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ali Motamed Nezhad, Zahra Behroozi, Keihan Kookli, Alireza Ghadaksaz, Seyedalireza Moghaddas Fazeli, Ali Moshiri, Fatemeh Ramezani, Molood Gooniband Shooshtari, Atousa Janzadeh
Summary: The results of the study show that both PBMT 90 and 117s have similar effects in relieving pain and improving functional recovery. The regulation of epigenetic mechanisms may be an important mechanism of action for PBMT 117s, highlighting the importance of radiation duration and cumulative energy in treatment efficacy.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arash Farzan, Ali Moshiri, Sina Andalib, Mostafa Shamsi, Nima Motamed
Summary: This study assessed the effects of simvastatin and low-level laser therapy (LLLT) on sutural bone formation in rats. The results showed that both simvastatin and LLLT significantly improved osteogenesis, and the combination of both interventions showed superior clinical results compared to other interventions.
JOURNAL OF LASERS IN MEDICAL SCIENCES
(2022)
Correction
Engineering, Biomedical
A. Oryan, Baghaban M. Eslaminejad, A. Kamali, S. Hosseini, F. A. Sayahpour, H. Baharvand
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Veterinary Sciences
Ahmad Khajeh, Ali Baniadam, Ahmad Oryan, Alireza Ghadiri, Hadi Naddaf
Summary: The study found that autograft of the nuchal ligament promotes tendon defect healing in donkeys by enhancing collagen diameter and fiber density, without causing neck swelling or angle changes. The transplanted tissue was mainly in the remodeling or maturation phase on day 120 postoperatively.
VETERINARY RESEARCH FORUM
(2021)
Article
Entomology
Naglaa A. AbdElKader, Eldessouky Sheta, Huda O. AbuBakr, Omnia A. A. El-Shamy, Ahmad Oryan, Marwa M. Attia
Summary: This study investigated the effects of a novel natural drug developed with new technology on highly prevalent larvae in donkeys. The combination of chitosan and ivermectin showed practical synergism beneficial for animal health.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)