Article
Biotechnology & Applied Microbiology
Peng Hu, Chengyao Ni, Pen Teng
Summary: The study found that artesunate has inhibitory effects on the proliferation, migration and invasion of non-small cell lung cancer cells, and induces apoptosis. This effect may be associated with decreased expressions of HuR and MMP-9 proteins.
Article
Oncology
Wei Yu, Xiao Zhang, Wei Zhang, Minggang Xiong, Yuhan Lin, Ming Chang, Lin Xu, Yi Lu, Yun Liu, Jian Zhang
Summary: The study found that 19-HB inhibits the proliferation, migration, and invasion, and promotes the apoptosis of NSCLC cells through the Wnt/beta-catenin pathway. Additionally, 19-HB inhibited the growth of xenograft tumors in nude mice with limited toxicity to the liver and kidney.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Quanfu Li, Yunkai Chu, Shengze Li, Liping Yu, Huayun Deng, Chunhua Liao, Xiaodong Liao, Chihyu Yang, Min Qi, Jinke Cheng, Guoqiang Chen, Lei Huang
Summary: This study identifies a novel role of mucin 1 (MUC1) in promoting mitophagy and maintaining the malignancy of cancer cells. MUC1 interacts with ATPase family AAA domain-containing 3A (ATAD3A) and induces its degradation, resulting in protection of PTEN-induced kinase 1 (Pink1) from ATAD3A-mediated cleavage. Inhibition of mitophagy suppresses MUC1-induced cancer cell activity. The findings provide a new therapeutic approach for MUC1-positive cancers.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Kentaro Minegishi, Yoh Dobashi, Hiroyoshi Tsubochi, Koichi Hagiwara, Yuko Ishibashi, Sachiyo Nomura, Ritsuko Nakamura, Yasukazu Ohmoto, Shunsuke Endo
Summary: The study demonstrated that TFF-1 is expressed and secreted in adenocarcinoma-derived lung cancer cells, where its overexpression drives cell cycle transition and increases apoptosis, while suppressing cell migration and invasion. The suppressive effects on proliferation and migration can be restored by transfection of TFF-1 specific siRNA.
ONCOTARGETS AND THERAPY
(2021)
Article
Biology
Jin Zhang, Qianli Ma, Qiduo Yu, Fei Xiao, Zhenrong Zhang, Hongxiang Feng, Chaoyang Liang
Summary: PSMD3 is overexpressed in lung cancer tissues and cells, promoting cell proliferation, migration, and invasion, as well as stabilizing ILF3 protein expression and deubiquitination. The ILF3 inhibitor YM155 can suppress tumor growth in the presence of PSMD3, indicating that the PSMD3/ILF3 axis may be a novel strategy for diagnosis and treatment of lung cancer.
Article
Biochemistry & Molecular Biology
Bin Huang, Gongzhi Wu, Chongxiong Peng, Xuyang Peng, Mingjiang Huang, Jianyang Ding, Huaizhong Zhang, Xuhui Wu
Summary: This study aimed to clarify the role of miR-126 in the biological behaviors of non-small cell lung cancer (NSCLC) cells, including cell proliferation, migration, invasion, and apoptosis. The results showed that miR-126 was significantly down-regulated in NSCLC, and overexpression of miR-126 inhibited cell proliferation, migration, and invasion while promoting cell apoptosis.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Food Science & Technology
Yu Kang, Xiao Wang, Xingchuan Wei, Dongli Li, Lishe Gan, Jingwei Jin, Rihui Wu, Panpan Wu, Zhaojun Sheng, Kun Zhang, Susan Goodin, Xuetao Xu, Xi Zheng
Summary: Both a-Humulene and sclareol in combination synergistically inhibit the growth of pancreatic cancer cells by inducing apoptosis, suppressing migration, invasion, and sphere formation. Mechanistically, the combination decreases the levels of NF-kappa B, pAkt, and Bcl-2 and increases the level of Bax. In addition, the combination also suppresses tumor growth in an in vivo xenograft model.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Dong-bin Wang, Xuan Li, Xi-Ke Lu, Zhong-yi Sun, Xun Zhang, Xia Chen, Lan Ma, Hong-gang Xia
Summary: Lung malignancy is a major cause of disease mortality worldwide, with TTR serving as a specific biomarker for clinical diagnosis. Research on the impact of abnormal TTR expression on NSCLC showed that upregulation of TTR suppressed cell proliferation, migration, invasion, and increased apoptosis. In vivo experiments confirmed that overexpression of TTR promoted cell apoptosis and inhibited tumor growth, suggesting a potential antitumor effect of TTR in human NSCLC progression.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Yuan, Huixia Guo, Jiajie Ding, Chan Jiao, Yalei Qi, Hajra Zafar, Xueyun Ma, Faisal Raza, Jianqiu Han
Summary: This study investigates the effects of PPO extracted from Edible mushroom on the proliferation, migration, invasion, and apoptosis of cancer cells in vitro and explores its therapeutic effects on tumors in vivo. The results suggest that PPO could effectively inhibit the growth of various cancers and has potential as a promising agent for cancer treatment.
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Medical Laboratory Technology
Jianzhong Wu, Ling Gao, Hong Chen, Xiaojun Zhou, Xialiang Lu, Zhongqi Mao
Summary: This study revealed that in poorly differentiated gastric cancer (PDGC), the upregulation of LINC02535 expression contributes to cell proliferation, migration, invasion, and wound healing, while its inhibition facilitates cell apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Plant Sciences
Mohd Mukrish Mohd Hanafi, Harisun Yaakob, Simon Gibbons, Jose M. Prieto
Summary: This study evaluated the effects of Marantodes pumilum Blume Kuntze plant extracts on prostate cancer cells in vitro. Active compound/s were identified and their mechanism of action was characterized. The extracts induced apoptosis, inhibited migration and invasion of cancer cells, and regulated gene expressions related to tumor growth and metastasis. The active compound was identified as 5-henicosene-1-yl-resorcinol.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
