Review
Pharmacology & Pharmacy
Zhiyi Zhang, Jie Song, Cao Xie, Jun Pan, Weiyue Lu, Min Liu
Summary: Pancreatic cancer is a highly malignant tumor that is difficult to diagnose early, with most patients diagnosed in advanced stages. Current main treatments include chemotherapy, which has not significantly improved patient prognosis.
Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.
Review
Oncology
Torben Frostrup Hansen, Camilla Qvortrup, Per Pfeiffer
Summary: Angiogenesis is a key element in the treatment strategy for colorectal cancer, with challenges in finding effective biomarkers and personalized treatments. The combination of immunotherapy and anti-angiogenic treatment brings new hope for patients.
Article
Biochemistry & Molecular Biology
Teymour Vahedpour, Jatinder Kaur, Salar Hemmati, Maryam Hamzeh-Mivehroud, Ali Akbar Alizadeh, Frank Wuest, Siavoush Dastmalchi
Summary: A new series of compounds for the inhibition of COX-2 were synthesized, with the lead compound showing significant COX-2 inhibition and antiproliferative activity. Molecular docking studies indicated that these compounds interact with key binding site residues of the COX-2 enzyme via multiple hydrophobic and hydrogen-bond interactions.
CHEMISTRY & BIODIVERSITY
(2021)
Editorial Material
Medicine, General & Internal
Oladapo O. Yeku, Dan L. Longo
Summary: This editorial discusses the scientific basis of a clinical trial conducted by Prager and colleagues, which tested the efficacy of trifluridine-tipiracil and bevacizumab in treating patients with refractory metastatic colorectal cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Chemistry, Medicinal
Ali Aliabadi, Elham Khanniri, Mohammad Mahboubi-Rabbani, Maryam Bayanati
Summary: Dual cyclooxygenase 2/15-lipoxygenase inhibitors offer a valuable alternative for the treatment of inflammatory diseases and prevention of cancer, with reduced side effects compared to classical NSAIDs and selective COX-2 inhibitors. This review provides an overview of the COX-2 and 15-LOX pathways and discusses various structural families of dual inhibitors, paving the way for the design of potentially-active anticancer agents with balanced dual inhibition of these enzymes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Uchenna Simon Ezenkwa, Clement Abu Okolo, Gabriel Olabiyi Ogun, Adegboyega Akere, Olufemi John Ogunbiyi
Summary: Emerging data indicates a negative role of cyclooxygenase-2 (COX-2) in colorectal carcinomas (CRC). Investigation in developing communities contributes to the understanding of these lesions. The study revealed an increasing COX-2 expression from normal to adenomatous polyp and CRC tissues, associated with poorer prognostic indicators. Although COX-2 is early present in CRC, it may have a secondary role in promoting tumor growth and invasiveness.
Article
Chemistry, Medicinal
Zhuming Zhang, Avijit Ghosh, Peter J. Connolly, Peter King, Thomas Wilde, Jianyao Wang, Yawei Dong, Xueliang Li, Daohong Liao, Hao Chen, Gaochao Tian, Javier Suarez, William G. Bonnette, Vineet Pande, Karen A. Diloreto, Yifan Shi, Shefali Patel, Beth Pietrak, Lawrence Szewczuk, Carlo Sensenhauser, Shannon Dallas, James P. Edwards, Kurtis E. Bachman, David C. Evans
Summary: This study reported a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure, showing significant inhibition of adenoma progression and survival extension in an APC(min/+) mouse model. However, their chemoprotective effects were mainly driven by systemic COX-2 inhibition, resulting in less than expected efficacies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pandurangan Subash-Babu, Alanoud Aladel, Taghreed N. Almanaa, Sahar Abdulaziz AlSedairy, Ali A. Alshatwi
Summary: Using ononitol monohydrate from Cassia tora can inhibit the proliferation of human colorectal cancer cells by suppressing inflammatory gene expression and increasing the expression of tumor-suppressor genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marina Baretti, Adrian. G. G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara. Y. Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt, Nilofer. S. S. Azad
Summary: This study evaluated the efficacy of PD-1 immune checkpoint inhibitor therapy in combination with DNMT and HDAC inhibitors in MMRp CRC. The results showed limited effectiveness of this combination therapy with relatively high side effects. Further research is needed to understand the epigenetic-induced immune changes and expand the potential applicability of checkpoint inhibitors in this setting.
CLINICAL EPIGENETICS
(2023)
Review
Pharmacology & Pharmacy
Aya A. Mabrouk, Mina Ibrahim Tadros, Wessam M. El-Refaie
Summary: Oral carcinoma is a global health threat with overexpression of COX-2 enzyme in cancer cells. COX-2 inhibitors have potential in oral cancer treatment, but their clinical efficacy is limited by poor aqueous solubility and adverse effects. Advancements in nano-drug delivery systems offer hope in overcoming these limitations and improving the efficacy of COX-2 inhibitors.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Musa El-Barghouthi, Ayman S. Hasan, Wajdy Al-Awaida, Hamzeh J. Al-Ameer, Jatinder Kaur, Kaita J. Hayashibara, Jeremy Fleming, Jessica Waknin, Shigeo Hayashibara, Muna Slewa, Samer M. Hamzeh, Khaled Bodoor, Joshua Daniel McLoud, Frank Wuest, Baker Jawabrah Al Hourani
Summary: A unique class of 1,5-disubstituted tetrazoles were designed and synthesized, showing enhanced inhibition potency towards COX-2 enzyme. Tetrazole 4 exhibited the highest inhibition potency for both COX-2 and COX-1 enzymes while displaying selectivity for COX-2. Among the compounds studied, only azole 5 showed anti-cancer activity against human immortalized myelogenous leukemia. Overall, the investigated compounds showed low cytotoxicity for HDFa cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Multidisciplinary Sciences
Cheok Wui Chee, Nor Hisam Zamakshshari, Vannajan Sanghiran Lee, Iskandar Abdullah, Rozana Othman, Yean Kee Lee, Najihah Mohd Hashim, Nurshamimi Nor Rashidid
Summary: This study aimed to identify potential anti-colorectal cancer compounds from the root bark of Morinda citrifolia and analyze their efficacy in vitro. The results showed that morindone and damnacanthal from this plant exhibited significant anti-colorectal cancer activity and selectivity.
Review
Oncology
Kaipeng Jin, Chao Qian, Jinti Lin, Bing Liu
Summary: COX-2 and PGE2 play important roles in chronic inflammatory diseases, increasing tumor incidence and promoting tumor growth and metastasis. The COX-2-PGE2 pathway affects tumor-associated immune cells and promotes tumor immune evasion.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Sri Harsha Narayana, Ujala Mushtaq, Basim Shaman Ameen, Chuhao Nie, Daniel Nechi, Iqra J. Mazhar, Mohamed Yasir, Saba Sarfraz, Gandhala Shlaghya, Safeera Khan
Summary: Colorectal cancer is a major health concern worldwide, and the prevention of CRC through COX-2 inhibitors is being studied. COX-2 inhibitors can decrease prostaglandin levels and modulate signaling pathways involved in CRC development. A systematic review was conducted to evaluate the protective effects of long-term usage of COX-2 inhibitors on CRC and their overall effect on the prognosis of the disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Ophthalmology
Fatma Savur, Orhan Aydemir, Nevin Ilhan
CUTANEOUS AND OCULAR TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nevin Ilhan, Huseyin Fatih Gul, Solmaz Susam, Necip Ilhan, Ruken Bardas
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2020)
Article
Ophthalmology
Hakan Yildirim, Orhan Aydemir, Mehmet Balbaba, Ibrahim Hanifi Ozercan, Nevin Ilhan
CUTANEOUS AND OCULAR TOXICOLOGY
(2020)
Article
Neurosciences
Ibrahim Halil Yasak, Mustafa Yilmaz, Murat Gonen, Metin Atescelik, Mehtap Gurger, Nevin Ilhan, Mehmet Cagri Goktekin
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Article
Respiratory System
Erdal In, Mutlu Kuluozturk, Teyfik Turgut, Aysegul Altintop Geckil, Nevin Ilhan
Summary: This study found that serum endocan levels were significantly higher in AECOPD patients compared to stable COPD patients and controls, and stable COPD patients had higher levels than controls as well. Additionally, serum endocan levels were correlated with lung function parameters and oxygen pressure, and positively correlated with disease duration and systolic pulmonary artery pressure. Serum endocan levels can also serve as an independent predictor of COPD exacerbation.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Huseyin Fatih Gul, Necip Ilhan, Nevin Ilhan, Ibrahim Hanifi Ozercan, Tuncay Kuloglu
Summary: The study aimed to investigate the protective effects of pomegranate extract and tangeretin alone or in combination in a rat breast cancer model. The results showed that the combined application of pomegranate extract and tangeretin may be more beneficial in preventing breast cancer development, by reducing tumor markers, angiogenesis parameters, and influencing protein expressions to decrease apoptosis and proliferation of cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Ophthalmology
Murat Erdag, Mehmet Balbaba, Nevin Ilhan, Ilknur Calik, Fatih Ulas, Yesari Eroksuz, Hakan Yildirim
Summary: This study investigated the protective effect of Filgotinib in an endotoxin-induced uveitis model in rats. The results showed that Filgotinib significantly reduced clinical activity and histopathological examination scores, as well as TNF-alpha and IL-6 levels. Therefore, Filgotinib may be an alternative treatment option in preventing the development of noninfectious uveitis.
INTERNATIONAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hakan Yildirim, Mehmet Balbaba, Murat Erdag, Ali Dal, Mehmet Canleblebici, Nevin Ilhan, Yesari Eroksuz
Summary: The study showed that nintedanib has a protective effect in endotoxin-induced uveitis, reducing levels of interleukin-6, tumor necrosis factor-alpha, and clinical activity scores. Histopathological examinations revealed a significant decrease in inflammatory cell infiltration, edema, and hyperaemia in the nintedanib group compared to the sham group.
CUTANEOUS AND OCULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nevin Ilhan, Ibrahim Bektas, Solmaz Susam, Ibrahim H. Ozercan
Summary: The study suggests that RA may be beneficial in preventing AOM-induced colon carcinogenesis formation, reducing adenocarcinoma rates and affecting circulatory oxidant-antioxidant status.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Medical Laboratory Technology
Mustafa Yilmaz, Mehmet Cagri Goktekin, Nevin Ilhan
Summary: The study found significant differences in serum subfatin concentrations between the STEMI and NSTEMI groups, with lower levels in NSTEMI patients compared to the control group. The receiver operating characteristic (ROC) analysis showed that subfatin had relatively high sensitivity and specificity for distinguishing between AMI and control, as well as between NSTEMI and STEMI.
Article
Obstetrics & Gynecology
Cengiz Sanli, Remzi Atilgan, Tuncay Kuloglu, Sehmus Pala, Nevin Ilhan
Summary: This study investigates the immunoreactivity of cholinergic receptor muscarinic 1 (CHRM1) in the ovarian tissues of rats with ovarian hyperstimulation syndrome (OHSS), aiming to explore the potential contribution of muscarinic activity to the pathophysiology of OHSS.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zafer Cambay, Nevin Ilhan, Solmaz Susam, Mehmet Hamdi Muz
Summary: The study revealed that patients with COPD had lower BMI levels, higher MDA and adiponectin levels, and lower IL-6 and visfatin levels compared to the control group. These parameters may play a crucial role in the development of COPD and in monitoring the treatment of COPD-related diseases.
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
(2021)
Article
Medicine, General & Internal
Cengiz Sanli, Remzi Atilgan, Tuncay Kuloglu, Sehmus Pala, Bilge Aydin Turk, Hasan Burak Keser, Nevin Ilhan
Summary: This experimental study found that increased TRPM2 immunoreactivity on hyperstimulated rat ovaries may be associated with edema and congestion in ovarian tissue. Furthermore, elevated levels of VEGF, TNFα, and MDA were also observed in the OHSS group compared to the control group.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Emergency Medicine
Ali Aksu, Mehmet Bugra Bozan, Nizamettin Kutluer, Burhan Hakan Kanat, Yavuz Selim Ilhan, Ahmet Turkoglu, Adile Ferda Dagli, Nevin Ilhan, Ayse Azak Bozan, Nurullah Aksoy
Summary: The study evaluated the use of chlorhexidine gluconate and metronidazole impregnated compresses in left colonic anastomosis safety in the presence of peritonitis. Results showed that cleaning the abdomen with antibacterial soaked material increased resection safety and anastomosis safety in primary anastomosis, demonstrating the importance of proper cleaning protocols in surgical procedures.
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
(2021)
Article
Biochemistry & Molecular Biology
S. Unuvar, S. Gursoy, A. Berk, B. Kaymaz, N. Ilhan, G. Aktay
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
