Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yuna Jia, Xiaoyong Huang, Haiyan Shi, MingMing Wang, Jie Chen, Huahua Zhang, Danyang Hou, Hongmei Jing, Juan Du, Huihui Han, Jing Zhang
Summary: This study investigated the expression and biological role of ADAMDEC1 in colorectal cancer (CRC). ADAMDEC1 was found to be differentially expressed in CRC and was shown to promote CRC proliferation, migration, and invasion while inhibiting apoptosis. Further analysis revealed that ADAMDEC1 induces epithelial-mesenchymal transition (EMT) through the activation of the Wnt/beta-catenin signaling pathway. ADAMDEC1 may serve as a potential therapeutic target for the treatment of metastatic CRC.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Oncology
Meng-Shun Sun, Lan-Ting Yuan, Chia-Hao Kuei, Hui-Yu Lin, Yen-Lin Chen, Hui-Wen Chiu, Yuan-Feng Lin
Summary: The study revealed that RGL2 is commonly upregulated in primary tumors of CRC patients, serving as a poor prognostic marker and promoting metastatic progression by regulating Wnt/beta-catenin signaling axis and KRAS.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Guo-Dong Han, Yuan Sun, Hong-Xia Hui, Ming-Yue Tao, Yang-Qing Liu, Jing Zhu
Summary: Our research aimed to explore the potential involvement of miR-1224 in the progression of gastric cancer (GC). We found that miR-1224 was lowly expressed in GC specimens and cell lines, and its overexpression inhibited cell proliferation, migration, and invasion in GC cells. Additionally, SATB1 was identified as a direct target of miR-1224 in GC, and the expression of beta-catenin and c-myc was significantly inhibited in miR-1224-overexpression cells. Our findings suggest that miR-1224 has the potential to be a therapeutic target and novel biomarker for GC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fei Gao, Jilai Yin, Yongcun Wang, Hao Li, Daping Wang
Summary: miR-182 overexpression is positively correlated with distant metastasis in cervical cancer patients. It promotes the growth of cervical cancer cells and affects the progression of cervical cancer through the Wnt/β-catenin axis and its downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Chemistry, Medicinal
Jude Tetteh Quarshie, Kwadwo Fosu, Nicholas Awuku Offei, Augustine Kojo Sobo, Osbourne Quaye, Anastasia Rosebud Aikins
Summary: This study demonstrates that cryptolepine, a plant-derived compound, suppresses CRC cell proliferation, stemness, and metastasis by inhibiting WNT3a-induced activation of the WNT/β-catenin signaling pathway. These findings suggest that cryptolepine may serve as a potential WNT inhibitor in CRC treatment.
Review
Oncology
Y. Taank, N. Agnihotri
Summary: Aberrant Wnt/beta-catenin signaling plays a central role in the carcinogenesis of colorectal cancer. While targeting this pathway holds potential for treatment, current approaches have not been successful in clinical practice, prompting the need for new strategies. Recent studies have identified beta-catenin regulators that show promise in modulating the pathway and influencing the development of CRC and other solid tumors. Further research on the detailed mechanisms of these regulators may lead to improved treatment approaches.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang, Yan Wen, Peipei Zhang
Summary: This study demonstrated that activation of WNT7b autocrine may contribute to colorectal cancer metastasis by triggering the EMT process through the Wnt/β-catenin signaling pathway. High levels of WNT7b autocrine secretion predict a poor outcome in patients with colorectal cancer and may be a promising candidate for clinical treatments.
Article
Oncology
Peng Liu, Jingyu Liu, Mengyang Ding, Yijing Liu, Yue Zhang, Xiaoming Chen, Zhenxu Zhou
Summary: This study found that the expression levels of FUT2 were higher in colorectal cancer (CRC) tissues compared to adjacent non-tumor tissues. Knockdown of FUT2 inhibited the proliferation, migration, and invasion of CRC cells and promoted apoptosis. FUT2 knockdown also affected the expression of several key proteins involved in CRC progression. These findings suggest that FUT2 could be a potential diagnostic biomarker and therapeutic target for CRC treatment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ting Deng, Yibo Hou, Gaoyang Lin, Chunyan Feng, Kewei Liu, Wenke Chen, Wei Wei, Laiqiang Huang, Xiaoyong Dai
Summary: Colorectal cancer (CRC) is a major cause of cancer-related deaths globally. Fibromodulin (FMOD) is a proteoglycan that plays a vital role in tumor growth and metastasis. This study found that FMOD is upregulated in CRC and associated with poor patient prognosis. A novel FMOD antagonist peptide, RP4, was developed and shown to inhibit CRC cell growth and metastasis, promote apoptosis, and affect the immune microenvironment. Mechanistically, RP4 blocked the Akt and Wnt/beta-catenin signaling pathways. FMOD is identified as a potential target for CRC treatment and RP4 as a potential clinical drug.
Article
Cell Biology
Wenlong Hu, Jie Shen, Yu Tao, Dan Donga, Sicheng Lu, Liu Li, Dongdong Sun, Minmin Fan, Changliang Xu, Weixing Shen, Chengtao Yu, Haibo Cheng
Summary: This study found that CCDC85C inhibits the proliferation and migration of colorectal cancer cells by binding to GSK-3 beta and promoting ubiquitination and degradation of beta-catenin.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Yuqiang Li, Mengxiang Tian, Wenxue Liu, Dan Wang, Zhongyi Zhou, Qian Pei, Yan Huang, Fengbo Tan, Cenap Guengoer
Summary: The expression of FSTL3 is significantly higher in colon cancer specimens, and its expression is associated with increased invasive and metastatic capacity of tumor cells. Transcriptional regulation of FSTL3 is dependent on YAP1 de-phosphorylation events, leading to activation of the beta-Catenin pathway and promotion of EMT processes. Pharmacological targeting of YAP1 may offer a promising therapeutic strategy for anti-metastasis in CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su, Xianglin Yuan
Summary: The study found that miR-199b-3p is significantly up-regulated in CTx-resistant colorectal cancer cells. Inhibiting miR-199b-3p can improve the sensitivity of CTx-resistant cells to CTx by regulating the Wnt/β-catenin signaling pathway. Mouse models confirmed that down-regulating miR-199b-3p can restore the inhibitory effect of CTx on tumor growth.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Physical
Nasir Rafique, Abdul Hannan Asif, Rajan Arjan Kalyan Hirani, Hong Wu, Lei Shi, Shu Zhang, Shuaijun Wang, Yu Yin, Shaobin Wang, Hongqi Sun
Summary: Increasing water pollution poses a significant threat to public health, necessitating efficient monitoring and remediation technologies for a clean environment. This study introduces a versatile heterojunction of Au nanoparticles modified phosphorus doped carbon nitride (Au/P-CN), which exhibits improved light absorption, rapid charge carrier separation, and enhanced electrical conductivity. A highly sensitive photoelectrochemical (PEC) sensor is successfully demonstrated using the Au/P-CN heterostructure for the detection of toxic 4-chlorophenol (4-CP), showing a wide linear range, low detection limit, excellent stability, selectivity, and reliable analysis in real samples. Additionally, the Au/P-CN heterostructure achieves efficient photocatalytic degradation with a high removal efficiency for 4-CP, outperforming its counterpart of Au nanoparticles modified graphitic carbon nitride (Au/g-CN). This work opens up a new pathway for the efficient and simultaneous detection and remediation of organic pollutants using versatile photoactive catalysts.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yangyang Yang, Lei Shi, Jingkai Lin, Panpan Zhang, Kunsheng Hu, Shuang Meng, Peng Zhou, Xiaoguang Duan, Hongqi Sun, Shaobin Wang
Summary: In this study, a magnetic FeOx@MnO2@SiO2 micromotor with multiple functions was designed, which demonstrated its catalytic performance in the activation of H2O2/peroxymonosulfate (PMS) for sustained motion and organic degradation. The correlations between catalytic efficiency and motion behavior/mechanism were also revealed.
Article
Materials Science, Multidisciplinary
Xin Wang, Peng Qin, Hongqi Sun, Lai-Chang Zhang
Summary: This study investigates the corrosion behavior and mechanism of laser powder bed fusion produced (LPBFed) Ti5Cu and its heat-treated counterparts in 3.5 wt% NaCl solution. Heat treatment enhances corrosion resistance by generating Ti2Cu phase and forming a stable oxide film. The Ti2Cu phase acts as a microanode, decelerating corrosion on the α-Ti phase. The as-LPBFed Ti5Cu exhibits the worst corrosion resistance due to increased electron diffusion rate and preferential corrosion of the thermodynamically unstable α'-Ti phase in the acidic environment.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Engineering, Chemical
Zhengxin Yao, Roufei Chen, Ning Han, Hongqi Sun, Ngie Hing Wong, Lusi Ernawati, Shaobin Wang, Jaka Sunarso, Shaomin Liu
Summary: This study investigates the catalytic performance of natural mineral manganese ore for peroxymonosulfate-based advanced oxidation processes. The results show that manganese ore enhances the degradation of phenol, tetrabromobisphenol A, rhodamine B, and methylene blue, making it a promising catalyst for in situ persistent organic pollutant remediation.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
P. Qin, L. Y. Chen, Y. J. Liu, C. H. Zhao, Y. J. Lu, H. Sun, L. C. Zhang
Summary: The corrosion behavior and mechanism of laser powder bed fusion (L-PBF) produced CoCrW were studied in a 0.9 wt% NaCl solution with a pH of 2. It was found that the corrosion resistance of the alloy increased after 28 days of immersion due to the formation of an oxide film, resulting in an increased corrosion potential and a decreased passivation current density. The corrosion mechanism of L-PBF-produced CoCrW could be explained by the formation and dissolution of the oxide film, leading to the shrinkage of the melt pools formed during the laser melting process.
Article
Energy & Fuels
Xinyuan Xu, Jinqiang Zhang, Hong Wu, Lei Shi, Jie Zhang, Kuan Ding, Shu Zhang, Shuaijun Wang, Shaobin Wang, Hongqi Sun
Summary: In this study, the concentration and position of sulfur vacancies in ultrathin ZnIn2S4 nanosheets were successfully controlled to optimize the photo-driven lignin model reforming process, leading to excellent selectivity for hydrogen and chemical monomers. The proton migration pathway was modulated through sulfur vacancy engineering, achieving high concentrations of sulfur vacancies in the bulk and on the surface of ZnIn2S4. This provides new mechanistic insights into biomass photoreforming and elucidates the structure/chemistry-catalysis correlation of ZnIn2S4 photocatalysts, which are crucial for photocatalyst design and solar fuel production.
Review
Chemistry, Physical
Aixin Deng, Yue Sun, Zhanqi Gao, Shaogui Yang, Yazi Liu, Huan He, Jinqiang Zhang, Shaomin Liu, Hongqi Sun, Shaobin Wang
Summary: Carbon nitride is a metal-free photocatalyst with great potential for solar energy conversion and pollutant treatment. However, its photocatalytic performance is hindered by slow charge carriers due to the high symmetry of its structure. This review presents the latest progress in creating an internal electric field (IEF) in carbon nitride-based heterojunctions to enhance separation and migration of charge carriers. The relationship between IEF and photocatalytic performance is explored, with suggestions for future research and challenges in IEF-driven photocatalysis.
Article
Chemistry, Multidisciplinary
W. Han, D. Li, X. Hu, W. Qin, H. Sun, S. Wang, X. Duan
Summary: In this study, the efficiency of carbon quantum dots (CQDs) as photocatalysts is improved by fine-tuning the surface chemistry through selectively substituting surface carbonyl group (C=O) with phenylhydrazine (PH). The modified CQDs-PH show enhanced light absorption and separation of photogenerated electron-hole pairs, leading to boosted generation of reactive oxygen species (ROS) via peroxymonosulfate (PMS) activation. Theoretical calculations demonstrate spatial separation of electrons and holes on CQDs due to the spontaneous surface polarization induced by PH functionalization. This research provides a feasible approach to enhance the photocatalytic activity of CQDs for sustainable water decontamination.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Engineering, Environmental
Zhihao Tian, Qianru Chen, Shiying Ren, Huayang Zhang, Wenjie Tian, Hongqi Sun, Shaobin Wang
Summary: An investigation into the influence of different cobalt salts on biomass conversion revealed that the melting points and anion species of cobalt salts are critical factors. Low-melting-point cobalt salts promote mesopore formation and graphitization of biomass, while high-melting-point cobalt salts form an amorphous carbon/cobalt sulfide nanoparticle composite with different catalytic mechanisms. This study provides insight into the rational design of biomass-derived carbon-based catalysts with desired active sites.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Environmental
Xinyuan Xu, Lei Shi, Shu Zhang, Zhimin Ao, Jinqiang Zhang, Shaobin Wang, Hongqi Sun
Summary: Biomass is a renewable, sustainable, and clean energy resource that can be used to combat the depletion of fossil fuels. Photocatalytic reforming is a novel technology that utilizes solar energy to convert biomass into hydrogen and valuable chemicals. This review focuses on the photoreforming of lignocellulose, particularly lignin, due to its complex and stubborn structure. The breakage of the β-O-4 linkage in lignin can be achieved through oxidation and reduction, and this review discusses different dissociation strategies and the selection of photocatalysts. Challenges related to photocatalysts, solvent, and post-treatment are identified, and potential solutions are provided.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
X. Wang, P. Qin, L. Y. Chen, H. Sun, L. C. Zhang
Summary: This study investigated the corrosion behavior of laser powder bed fusion produced Ti5Cu and its heat-treated counterparts (named as HT-740 and HT-900) in Hank's solution. The presence of acicular α'-Ti phase in LPBFed Ti5Cu was found to be beneficial to corrosion, while the corrosion resistance of HT-740 and HT-900 increased due to the dual-phase microstructure (α'/α-Ti + Ti2Cu) or increased content of Ti2Cu phase. The Ti2Cu phase provided an 'envelope' protection to the α'/α-Ti phase and slowed down the micro-galvanic reaction between α'/α-Ti phase and Ti2Cu phase.
Article
Engineering, Environmental
Rajan Arjan Kalyan Hirani, Abdul Hannan, Nasir Rafique, Lei Shi, Wenjie Tian, Haitao Wang, Hongqi Sun
Summary: Advanced oxidation processes (AOPs) have shown great potential for wastewater remediation in recent years. Graphene-based composites have been widely used for catalytic oxidation, but the recovery and reusability of catalysts remain a challenge. To address this issue, researchers created three-dimensional graphene-based composites and successfully catalyzed the oxidation of sulfamethoxazole (SMX), achieving catalyst recovery and reusability.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Chemical
Rajan Arjan Kalyan Hirani, Abdul Hannan Asif, Nasir Rafique, Lei Shi, Shu Zhang, Martin Saunders, Wenjie Tian, Shaobin Wang, Hongqi Sun
Summary: In this study, three-dimensional nitrogen-doped graphene macrostructures (3D-NGMs) were synthesized and used for the activation of peroxydisulfate (PS) to degrade sulfamethoxazole (SMX). The nitrogen configuration in the sp2 hybridised carbon network of the catalytic cubes was found to play an important role in the advanced oxidation processes. The optimal N-loading in NGC3 cubes showed outstanding performance for SMX degradation, and a possible reaction mechanism was proposed based on comprehensive studies on radical generation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Shuoyuan Tian, Yu Yin, Mengxuan Liu, Lei Shi, Shu Zhang, Abdul Hannan Asif, Xuan Li, Mengqiong Liu, Xiaoguang Duan, Shaobin Wang, Hongqi Sun
Summary: The discharge of difficult-to-degrade pharmaceuticals into water systems has had severe impacts on public health and ecosystems. Advanced oxidation processes (AOPs) have proven effective in removing these persistent pollutants, with single-atom catalysts (SACs) being the leading materials due to their highly exposed metal sites. In this study, hollow spherical graphitic carbon nitride (hsCN) incorporated with copper species was developed as a Fenton-like catalyst for the removal of acetaminophen (ACT). The SACu-hsCN material, with atomically dispersed Cu-N3 sites and a hollow structure, achieved the highest ACT removal efficiency of 94.8% within 180 minutes of Fenton-like reactions, surpassing the 56.7% removal efficiency of AGCu-hsCN with aggregated Cu particles. Furthermore, SACu-hsCN remained active even after four cycles of regeneration. Mechanistic investigations revealed that both hydroxyl radicals (•OH) and singlet oxygen (1O2) contributed to ACT degradation in the SACu-hsCN/H2O2 system, with non-radical 1O2 playing the dominant role.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jingkai Lin, Yantao Wang, Wenjie Tian, Huayang Zhang, Hongqi Sun, Shaobin Wang
Summary: A series of macroporous carbon nitride-supported single-atom transition metal catalysts have been developed for solar light-driven photocatalytic gaseous NH3 splitting. The optimized Ni-MCN catalyst shows a high H-2 production rate due to the presence of Ni-N-4 sites, which improve the optical properties, accelerate charge carrier separation/transfer, and boost NH3 splitting kinetics. These findings provide valuable guidelines for the rational design of single-atom catalysts for energy- and cost-effective photocatalytic NH3 splitting.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
