Article
Chemistry, Inorganic & Nuclear
Truong Tan Trung, Nguyen Thi Thanh Huong, Tran Dinh Loc, Nguyen Thanh Si, Vo Quoc Khuong, Pham Tran Nguyen Nguyen
Summary: The present study reports a green synthesis route of silver nanoparticles using the flower extract of Quisqualis indica Linn. The physicochemical characteristics of the nanoparticles and the stabilizing compounds in the flower extract were investigated. The study also calculated the quantum chemical parameters of compounds in the flower extract and evaluated their binding affinity with bacterial proteins.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Evgenii V. Plotnikov, Maria S. Tretayakova, Diana Garibo-Ruiz, Ana G. Rodriguez-Hernandez, Alexey N. Pestryakov, Yanis Toledano-Magana, Nina Bogdanchikova
Summary: This study synthesized silver nanoparticles by irradiation treatment of silver nitrate solution with various stabilizers in a liquid medium and investigated their cytotoxic properties against cancer cells. The results showed that the silver nanoparticles had a dose-dependent cytotoxic effect on tumor cells, and the particles obtained with the combination of polyvinylpyrrolidone and collagen hydrolysate exhibited stronger cytotoxicity compared to samples stabilized with only collagen or only polyvinylpyrrolidone. The AgNPs formulation prepared with a mixture of PVP and PH showed significantly higher activity than other reported formulations.
Article
Biochemistry & Molecular Biology
Guo-Kai Wang, Yun-Peng Sun, Wen-Fang Jin, Yang Yu, Jian-Yong Zhu, Jin-Song Liu
Summary: Sixteen new limonoids and 18 known limonoids were isolated from Swietenia macrophylla, and their structures were determined. Limonoid 19 exhibited significant cytotoxic effects against A375 cells and induced apoptosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qinglian Hu, Liwang Xu, Xiaoyu Huang, Yuxuan Duan, Dongchang Sun, Zhengwei Fu, Yunfen Ge
Summary: In this study, a collaborative MOF system with dual-response properties was constructed for intelligent drug release. The system demonstrated excellent biocompatibility and synergistic efficacy, showing promising potential for biomedical applications.
Article
Chemistry, Multidisciplinary
Kakoli Malakar, Balasubramaniam Selvakumaran, Mariappan Murali, Pitchan Arul Prakash, Somasundaram Sangeetha, Winaki P. Sohtun, Mohamed Sultan Mohamed Jaabir, Marappan Velusamy
Summary: Eight novel mixed-ligand copper(ii) complexes were characterized and found to exhibit excellent activity and cytotoxicity in cancer treatment.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alina Aktanova, Tatjana Abramova, Ekaterina Pashkina, Olga Boeva, Lyubov Grishina, Ekaterina Kovalenko, Vladimir Kozlov
Summary: Research on cucurbiturils is focused on improving solubility, selectivity, stability, binding and release properties. The study found that cucurbiturils have high biocompatibility, with no cytotoxicity at concentrations below 0.3 mM. However, they may increase lymphocyte apoptosis levels and enhance hemolysis in relevant media.
Article
Chemistry, Inorganic & Nuclear
Zhen-Fang Zeng, Qiu-Ping Huang, Jie-Hui Cai, Guang-Jin Zheng, Li-Jin Qin, Qiu-Chan Huang, You-Huan Wei
Summary: A novel copper (II) complex was successfully synthesized and characterized for its binding properties with CT-DNA and HSA. The complex exhibited intercalative bindings with CT-DNA and HSA, resulting in fluorescence quenching. In vitro assays showed the complex's superior anti-proliferative effects on various cancer cell lines compared to cisplatin, with dose- and time-dependent induction of apoptosis/necrosis and cell cycle arrest at G0/G1 phase in HepG2 cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Patrycja Klos, Magdalena Peruzynska, Magdalena Baskiewicz-Halasa, Paulina Skupin-Mrugalska, Malgorzata Majcher, Magdalena Sawczuk, Bartosz Szostak, Marek Drozdzik, Boguslaw Machalinski, Dariusz Chlubek
Summary: The study compared the anti-cancer activity of free thymoquinone and thymoquinone-loaded liposomes on melanoma cells. The results showed that thymoquinone had different antiproliferative and proapoptotic effects on different melanoma cell lines, and thymoquinone-loaded liposomes exhibited stronger cytotoxicity on the cells.
Article
Chemistry, Applied
Elumalai Kowsalya, Kithiyon MosaChristas, Chinna Rani Inbaraj Jaquline, Pannerselvam Balashanmugam, Thiyagarajan Devasena
Summary: Green synthesis of functionalized gold nanoparticles using leaf aqueous extracts from 10 different plants was successful, with Pterygota alata showing enhanced antioxidant activity and potent anticancer efficacy against MCF-7 breast cancer cells. The phytosynthesized AuNPs may be a promising anti-cancer strategy for breast cancer without toxicity to normal cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
B. Jyothish, John Jacob
Summary: This study evaluated the physical properties and anticancer characteristics of ZnFe2O4 and AlxZn1-xFe2O4 nanoparticles. The results showed that with increasing annealing temperatures, the micro strain values of the nanoparticles decreased, as well as the band gap energy. In cell experiments, these nanoparticles exhibited anticancer activities.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Integrative & Complementary Medicine
Haleh Forouhandeh, Zahra Rezaei Param, Ommoleila Molavi, Parina Asgharian, Vahideh Tarhriz
Summary: This study evaluated the anti-proliferative activity of E. caucasicum on melanoma cancer cells and non-cancerous cells. The n-Hexane extract and its 40% and 60% fractions showed the highest cytotoxic effect against the B16F10 cell line, inhibiting growth through induction of apoptosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Chemistry, Inorganic & Nuclear
Yong-Po Zhang, Zhong-Ying Ma, Pei-Pei Qiao, Chun-Yan Gao, Jin-Lei Tian, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu, Shi-Ping Yan
Summary: The study investigated the structure-activity relationship of two new copper complexes. It found a synergistic effect between the dinuclear ligand and copper ions, as well as the flexibility of the mononuclear ligand and copper ions, impacting nuclease activity and cytotoxicity. Both complexes exhibited inhibitory activity against human tumor cells, with complex 2 showing effectiveness in inhibiting cell proliferation and inducing apoptosis in HeLa cells via a ROS-triggered pathway.
Article
Toxicology
Yanyan Liao, Weiyi Wang, Zhihui Li, Yahong Wang, Lu Zhang, Xiaomei Huang, Peng Cai
Summary: This study utilized nonlabeled proteomics and bioinformatics analysis to investigate the proteomic response to graphene oxide (GO) in A549 cells, revealing that GO may exert toxic effects on cells by regulating gene transcription, immune response, cell growth, and apoptosis. Ingenuity pathway analysis identified key node proteins such as SMARCA4, TGF-beta 1, and TP53 at the center of the protein interaction network, which may play a crucial role in regulating GO toxicity and developing biomarkers for GO-induced pulmonary toxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Liping Zou, Guiping Cheng, Chengcheng Xu, Heyu Liu, Yingying Wang, Nianyu Li, Xiaorong Fan, Changhong Zhu, Wei Xia
Summary: CuNPs induce oxidative stress in human ovarian granulosa cells, possibly through the MAPK14-Nrf2 signaling pathway to induce HO-1 expression, but HO-1 can protect cells from oxidative stress induced by CuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Medicine, Research & Experimental
Amirhossein Bahreyni, Yasir Mohamud, Honglin Luo
Summary: Melanoma, the deadliest form of skin cancers, has unsatisfying clinical outcomes despite recent efforts in immunotherapeutic strategies. Factors such as side-effects, immunosuppressive tumor microenvironment, and tumor heterogeneity hinder efficient cancer immunotherapy. Nanotechnology-based approaches have been developed to enhance efficacy and reduce toxicity. Recent studies have shown the revolutionary potential of nanomaterials in immunotherapy for melanoma. This review highlights the integration of nanotechnology and cancer immunotherapy in melanoma treatment, emphasizing the therapeutic advantages for patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)