Article
Oncology
Yuna Jia, Xiaoyong Huang, Haiyan Shi, MingMing Wang, Jie Chen, Huahua Zhang, Danyang Hou, Hongmei Jing, Juan Du, Huihui Han, Jing Zhang
Summary: This study investigated the expression and biological role of ADAMDEC1 in colorectal cancer (CRC). ADAMDEC1 was found to be differentially expressed in CRC and was shown to promote CRC proliferation, migration, and invasion while inhibiting apoptosis. Further analysis revealed that ADAMDEC1 induces epithelial-mesenchymal transition (EMT) through the activation of the Wnt/beta-catenin signaling pathway. ADAMDEC1 may serve as a potential therapeutic target for the treatment of metastatic CRC.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Long-Jiang Chen, Lun Wu, Wei Wang, Lu-Lu Zhai, Feng Xiang, Wei-Bo Li, Zhi-Gang Tang
Summary: The study identified a lncRNA called linc01614 which is upregulated in pancreatic cancer tissues and cell lines. Knockdown of linc01614 inhibits cell proliferation, migration, and invasion, and it stabilizes beta-catenin protein to activate the WNT/beta-catenin signaling pathway. This study suggests that linc01614 may function as an oncogene and could be a potential therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Wenlong Hu, Jie Shen, Yu Tao, Dan Donga, Sicheng Lu, Liu Li, Dongdong Sun, Minmin Fan, Changliang Xu, Weixing Shen, Chengtao Yu, Haibo Cheng
Summary: This study found that CCDC85C inhibits the proliferation and migration of colorectal cancer cells by binding to GSK-3 beta and promoting ubiquitination and degradation of beta-catenin.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Oncology
Pu-Hyeon Cha, Jeong-Ha Hwang, Dong-Kyu Kwak, Eunjin Koh, Kyung-Sup Kim, Kang-Yell Choi
Summary: In colorectal cancer, the loss of APC activates Wnt/beta-catenin signaling, leading to the Warburg effect and affecting cancer cell metabolism. PKM2 and LDHA were identified as key molecules regulated by Wnt/beta-catenin signaling, with APC loss increasing their expression, resulting in increased glucose consumption and lactate secretion.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Endocrinology & Metabolism
Daniil Sokolov, Neha Sharda, Banabihari Giri, Md Sazzad Hassan, Damandeep Singh, Agnieszka Tarasiewicz, Charity Lohr, Urs von Holzen, Tibor Kristian, Jaylyn Waddell, Russel J. Reiter, Hafiz Ahmed, Aditi Banerjee
Summary: In this study, the combination of melatonin and andrographolide was found to inhibit the growth of colon cancer colospheroids by downregulating the beta-catenin signaling pathway and inhibiting angiogenesis. This dual therapy reduced stemness and induced cell death through increased reactive oxygen species levels and decreased mitochondrial membrane potential and ATP level. In addition, it also inhibited the Wnt/beta-catenin pathway and reduced the expression of genes related to angiogenesis.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is rising, with lifestyle factors and genetic background playing a potential role. The study found a missense mutation, HNF1AA98V, in the Hepatic Nuclear Factor 1α (HNF1A) gene, which reduces DNA binding ability. In mice, introducing the HNF1AA98V variant and feeding a high-fat or high-sugar diet led to an increased formation of colonic polyps. The study also revealed alterations in gene expression and signaling pathways related to metabolism, immunity, and lipid biogenesis.
Article
Oncology
Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhongxue Fu
Summary: This study found that Sestrin2 inhibits the progression of colorectal cancer by suppressing cell proliferation, migration, and colony formation. It also affects the cancer stemness properties. This is achieved through downregulation of the Wnt signaling pathway. The findings suggest that Sestrin2 could be a promising therapeutic target for colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Guoqiang Yan, Shiquan Li, Meng Yue, Chenyao Li, Zhenhua Kang
Summary: The study revealed that KDM5B is abundantly expressed in colorectal cancer tissues and cells, and high KDM5B expression is associated with poor prognosis. KDM5B activates the Wnt/beta-catenin pathway by downregulating CCL14, promoting the progression of colorectal cancer.
Article
Biochemistry & Molecular Biology
Teerapich Kasemsuk, Natthiya Saehlim, Patcharee Arsakhant, Gunya Sittithumcharee, Seiji Okada, Rungnapha Saeeng
Summary: A novel series of acanthoic acid analogues containing triazole moiety were synthesized, with 3d exhibiting the strongest cytotoxic activity. Computational studies showed that 3d has high binding energy with CDK-2 and EGFR protein kinases, indicating its potential as an anticancer agent.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Rada Bunthawong, Uthaiwan Sirion, Arthit Chairoungdua, Kanoknetr Suksen, Pawinee Piyachaturawat, Apichart Suksamrarn, Rungnapha Saeeng
Summary: Two new series of andrographolide analogues were designed and synthesized from natural andrographolide, showing different cytotoxicity against cancer cells. Compounds with formyl group exhibited selective activity on P-388 cell line. Computational studies revealed the importance of specific functional groups in cytotoxicity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Ye-Xing Cao, Patamawadee Silalai, Chun-Fang Liu, Ke-Yin Yu, Xu Bao, Xian-He Zhao, Rungnapha Saeeng, Chun-An Fan
Summary: This study presents a novel hypervalent-iodine(III)-mediated tandem reaction for the synthesis of structurally interesting and synthetically useful aziridines. The resulting densely functionalized aziridines offer a platform for accessing architecturally diverse aza-heterocycles through selective ring-opening transformations initiated by the reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Medicinal
Patamawadee Silalai, Dumnoensun Pruksakorn, Arthit Chairoungdua, Kanoknetr Suksen, Rungnapha Saeeng
Summary: Twenty six propargylamine mycophenolate analogues were synthesized and screened for cytotoxic activity against cancer cells, with some compounds demonstrating selective toxicity towards neuroblastoma cells. Compound 6a was identified as a potential therapeutic target for cancer treatment based on molecular docking results. The propargylamine mycophenolate scaffold shows promise as a starting point for developing new anticancer drugs for neuroblastoma.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Nutthanicha Ketsomboon, Rungnapha Saeeng, Klaokwan Srisook, Uthaiwan Sirion
Summary: This study introduces a convenient method for the one-pot synthesis of long alkyl-chain triazolylglycosides using ionic liquid as dual promoter and solvent. The approach involves a sequential one-pot two-step glycosidation-CuAAc click reaction to achieve products in moderate to high yields, and successfully prepares non-ionic monocatenary triazolylglycoside surfactants with excellent yields, which were further evaluated for their cytotoxic activity.
TETRAHEDRON LETTERS
(2021)
Article
Pharmacology & Pharmacy
Anisha Mazumder, Anupma Dwivedi, Wirat Assawapanumat, Rungnapha Saeeng, Witaya Sungkarat, Norased Nasongkla
Summary: In this study, galactose-targeted and non-targeted micelles were designed to enhance the anticancer activity and achieve targeted imaging using RSPP050 as an anticancer agent and superparamagnetic iron oxide (SPIO) as a contrast agent. The results showed that galactose micelles had higher drug loading content and cytotoxicity compared to non-targeted micelles. Moreover, targeted SPIO micelles decreased the magnetic resonance imaging (MRI) intensity, indicating their potential as a contrast agent for hepatocellular carcinoma.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Organic
Suttida Rinkam, Warapong Senapak, Sarayut Watchasit, Rungnapha Saeeng, Uthaiwan Sirion
Summary: A convenient and practical method for the synthesis of unsymmetrical triarylmethanes was demonstrated using a Bronsted acidic ionic liquid as the catalyst in a one-pot three-component double Friedel-Crafts reaction at 80 degrees C. The reaction was successful under metal- and solvent-free conditions, yielding moderate to high yields of the desired products from a wide range of substrates. The mechanism of the reaction was studied using quantitative NMR analysis.
Article
Biochemistry & Molecular Biology
Bodee Nutho, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Patcharee Arsakhant, Rungnapha Saeeng, Thanyada Rungrotmongkol
Summary: This study investigates the potential of twenty-one 12-dithiocarbamate-14-deoxyandrographolide analogues as inhibitors of SARS-CoV-2 Mpro through in vitro and in silico studies. The findings suggest that four compounds show promising inhibitory activity against SARS-CoV-2 Mpro, highlighting their potential as antiviral agents.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Supusson Pengnam, Purin Charoensuksai, Boon-ek Yingyongnarongkul, Rungnapha Saeeng, Hasan Uludag, Prasopchai Patrojanasophon, Praneet Opanasopit, Samarwadee Plianwong
Summary: Breast cancer is the second leading cause of cancer-related death in the US. This study developed a chitosan derivative-stabilized 3nAG nanosuspension and improved its efficacy in killing breast cancer cells by adding siRNA.
Article
Chemistry, Multidisciplinary
Patamawadee Silalai, Suwichada Jaipea, Jiraporn Tocharus, Anan Athipornchai, Apichart Suksamrarn, Rungnapha Saeeng
Summary: The designed and synthesized 1,2,3-triazole-genipin analogues showed neuroprotective activity and inhibition of butyrylcholinesterase. They have the potential to be promising lead compounds as anti-Alzheimer's agents.
Article
Chemistry, Organic
Thewika Benchawan, Rungnapha Saeeng
Summary: An efficient method for selective synthesis of mono- and bis-sulfenylindoles was developed using a novel aerobic catalytic oxidation system KI/SeO2 for sulfenylation of indoles with disulfide/thiols. The reaction features easy operation, mild reaction conditions, good atom economy, and metal-free approach, leading to desired products in high yields.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Suwichada Jaipea, Natthiya Saehlim, Waraporn Sutcharitruk, Anan Athipornchai, Kornkanok Ingkaninan, Rungnapha Saeeng
Summary: The alkaloid piperine 1 extracted from the black pepper plant (Piper nigrum L.) was converted to piperine amide derivatives (3a-3z) through condensation with various piperazine derivatives and secondary amines. These synthesized compounds were evaluated for their antioxidant and inhibition activities against AChE and BChE, which are important targets for Alzheimer’s disease therapy. Most of the compounds showed good antioxidant behavior and potent inhibition of AChE and BChE activities. In particular, compound 3c exhibited the highest AChE inhibition, while compounds 3v, 3x, and 3z showed better BChE inhibitory activities than galantamine. Docking studies confirmed their good binding energies to the target enzymes, suggesting their potential as anti-Alzheimer's drugs.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Plant Sciences
Nittaya Boonmuen, Kanoknetr Suksen, Mintra Kaewkittikhun, Laongthip Ruknarong, Patamawadee Silalai, Rungnapha Saeeng, Arthit Chairoungdua, Sunhapas Soodvilai, Duangrat Tantikanlayaporn
Summary: While obesity is a global health threat, effective pharmacological interventions have been limited. This study explored the use of a genipin analogue, G300, derived from Gardenia jasminoides Ellis, as a potential therapeutic agent for obesity. G300 was found to suppress adipogenic differentiation and lipid accumulation in adipocytes, and improve adipocyte function. These findings suggest that G300 has the potential to be a novel treatment for obesity and related disorders.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Organic
Patamawadee Silalai, Rungnapha Saeeng
Summary: This paper presents the acid-controlled divergent synthesis of 3-pyrrolidin-2-yl-1H-indoles and symmetric and unsymmetrical bis(indolyl)methanes (BIMs) through photocatalyzed decarboxylative coupling and Friedel-Crafts alkylation reactions. The method offers C-H functionalization, switchable formation of two products, room-temperature conditions, low photocatalyst loadings, absence of strong oxidant, and moderate to excellent yields. It has been successfully applied for the synthesis of natural product vibrindole A and 1,1-bis(1H-indol-3-yl)-2-phenylethane.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nipaphorn Ponpao, Warapong Senapak, Rungnapha Saeeng, Jaray Jaratjaroonphong, Uthaiwan Sirion
Summary: This study established a beneficial, scalable, and efficient methodology for synthesizing aniline-based triarylmethanes using a Bronsted acidic ionic liquid as a catalyst, achieving high yields with a broad range of substrates. Additionally, alternative aromatic nucleophiles were also studied, leading to a diversity of triarylmethane derivatives in high to excellent yields.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
