Article
Chemistry, Applied
Chao Xu, Shui Guan, Jianqiang Xu, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun
Summary: In this study, protocatechuic acid was grafted onto carboxymethyl chitosan to enhance antioxidant effect, where the conjugates showed improved radical scavenging activities and chelating activity. The prepared hydrogel exhibited sustained release of PCA-containing degraded fragment and protective effect against oxidative damage, suggesting its potential in drug release and tissue engineering applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Ying Li, Lezhen Dong, Yahui Liu, Qin Chen, Zufang Wu, Lingyi Liu, Mohamed A. Farag, Lianliang Liu
Summary: The effects of covalent binding of protocatechuic acid (PA) and gallic acid (GA) to lactoferrin (LF) on the structure, functional, and antioxidant properties of the protein conjugate were investigated. The LF-PA/GA conjugates showed altered hydrodynamic diameter and zeta-potential, but their antioxidant activities remained unchanged.
Article
Physiology
Jeremy A. Bigalke, Huanjia Gao, Qing-Hui Chen, Zhiying Shan
Summary: Salt-sensitivity is a major factor in the development of hypertension, and the role of the brain orexin system in the pathology of salt-sensitive hypertension remains to be explored. This study demonstrated that orexin signaling through the OX1R in the PVN plays a critical role in the onset and maintenance of hypertension in the DOCA-salt model, involving the activation of AVP-producing neurons and subsequent release of AVP into the periphery.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chang Liu, Chujie Zhang, Mengqiu Li, Jing Fu, Haichen Yang, Wenhan Ge, Yan Shi, Yang Lee, Cheng Huang
Summary: This study investigated the interaction between protocatechuic acid (PCA) and human serum albumin (HSA), as well as its protective effects against oxidative stress and pulmonary fibrosis. The results showed that PCA can protect human type II alveolar epithelial cells (AECs) by reducing oxidative stress, inflammation, and apoptosis, possibly through regulation of the NF-jB signaling pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Madeline de Souza Correa, Nayara Lais Boschen, Paulo Rogerio P. Rodrigues, Marcos L. Corazza, Agnes de Paula Scheer, Rosemary Hoffmann Ribani
Summary: Blackberry seed extracts obtained by supercritical CO2 and ethanol extraction showed good antioxidant potential, with high total phenolic content and phenolic compound concentration. The extracts also exhibited a protective effect against the oxidation of soybean oil.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Biochemistry & Molecular Biology
Qiaoli Zhao, Liuping Fan, Yuanfa Liu, Jinwei Li
Summary: In this study, chitosan was functionalized with protocatechuic acid and used to improve the stability of 13-carotene in Pickering emulsions. The grafting ratio of protocatechuic acid in chitosan conjugates was found to be dependent on the molecular weight of chitosan. The conjugates exhibited reduced crystallinity and thermal stability and improved antioxidant activity. Additionally, the conjugate particles significantly improved the stability of 13-carotene in Pickering emulsions and showed higher oxidation stability compared to chitosan particles. These results provide valuable information for the application of chitosan-protocatechuic acid conjugates in emulsion systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zhaoxia Li, Yujuan Liu, Fang Wang, Zhuanglei Gao, Mohamed A. Elhefny, Ola A. Habotta, Ahmed E. Abdel Moneim, Rami B. Kassab
Summary: Arsenic is a toxic metalloid that is abundantly found in nature and used in many industries. This study investigated the neuroprotective potential of protocatechuic acid (PCA) against arsenic-induced neurotoxicity in mice, showing that PCA can positively impact oxidative stress and cytokine levels induced by arsenic exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Engineering, Multidisciplinary
Chen Zhou, Ruiling Xu, Xiaowen Han, Lei Tong, Li Xiong, Jie Liang, Yong Sun, Xingdong Zhang, Yujiang Fan
Summary: Injectable antioxidant hydrogels composed of protocatechuic acid (PA)-mediated carboxylated chitosan (CCS) and oxidized hyaluronic acid (OHA) conjugate were designed to reduce oxidative stress and promote wound healing. These hydrogels exhibited stable chemical structure, satisfactory physical properties, and effective antibacterial properties. In addition, the hydrogels demonstrated significant antioxidant capacity and promoted collagen deposition in wound healing in animal tests.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Plant Sciences
Sujith Thatipelli, Murugammal Shanmugam, Shakila Ramachandran, Gopinath Pushparathinam
Summary: The roots of H. indicus are widely used in traditional medicine systems in India, and are often substituted with D. hamiltonii in the herbal market. In this study, a validated high-performance thin layer chromatography (HPTLC) method was developed for the quantification of five marker compounds in H. indicus and D. hamiltonii. The method can be used to assess the quality of these plants and herbal formulations containing them.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2023)
Article
Peripheral Vascular Disease
Ying Gao, Wenqiang Yu, Jinfang Song, Jiayi Nie, Zichan Cui, Shihong Wen, Benquan Liu, Hua Liang
Summary: Myeloid JMJD3 ablation attenuates kidney inflammation and fibrosis in DOCA salt-induced hypertension, leading to improved kidney function and reduced injury. Inhibition of myeloid JMJD3 may be a potential therapeutic target for hypertensive nephropathy.
HYPERTENSION RESEARCH
(2023)
Article
Environmental Sciences
Alaa Jameel A. Albarakati
Summary: This study confirmed the protective effect of protocatechuic acid on carrageenan-induced paw edema in mice, which may be attributed to its antioxidant and anti-inflammatory properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Paul Thomas, Emmanuel Essien, Anwanabasi Udoh, Bright Archibong, Ofonasaha Akpan, Emediong Etukudo, Marinella De Leo, Olorunfemi Eseyin, Guido Flamini, Kola Ajibesin
Summary: The study evaluated the anti-inflammatory, analgesic, and antioxidant activities of Uapaca staudtii stem bark extract and fractions, and isolated protocatechuic acid and betulinic acid as bioactive compounds. The results demonstrated significant medicinal value of Uapaca staudtii stem bark in treating pain and inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Li-Jun Li, Shuo Chao, Shu-Xian Zhao, Jun Lu, Xiao-Yuan Zhang, Yong Zhao, Ming-Hui Zhao, Gui-An Huang, Shen Yin, Qing-Yuan Sun, Lei Zhao, Zhao-Jia Ge
Summary: Protocatechuic acid (PCA), an important bioactive component of tea, can delay oocyte ageing, improve oocyte quality, and enhance fertilization and embryo development rates.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Osaze Edosuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan
Summary: The study showed that fumarate can reduce hypertension, renal injury, and improve the redox state of the kidney in DOCA/salt hypertension through selective reduction of L-arginine metabolism.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Agriculture, Dairy & Animal Science
Shad Mahfuz, Hong-Seok Mun, Muhammad Ammar Dilawar, Keiven Mark B. Ampode, Chul-Ju Yang
Summary: Protocatechuic acid (PCA) is a phenolic compound derived from natural plants, known for its antioxidant, anti-inflammatory, and antimicrobial properties. It has been shown to enhance the antioxidant status, immune function, antimicrobial activity, intestinal health, and growth performance of farm animals. However, the practical application of PCA in animal nutrition, including dosages and its mode of action on animal health, remains unclear.
Article
Clinical Neurology
Fatemeh Nazari, Vahid Shaygannejad, Mehrdad Mohammadi Sichani, Marjan Mansourian, Valiollah Hajhashemi
Article
Urology & Nephrology
Fatemeh Nazari, Vahid Shaygannejad, Mehrdad Mohammadi Sichani, Marjan Mansourian, Valiollah Hajhashemi
Article
Pharmacology & Pharmacy
Shiva Nasr, Jaleh Varshosaz, Valiolah Hajhashemi
PHARMACOLOGICAL REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Valiollah Hajhashemi, Mustafa Ghanadian, Abbasali Palizaban, Karim Mahnam, Hamed Eshaghi, Bahareh Gheisari, Hojjat Sadeghi-Aliabadi
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2020)
Article
Chemistry, Physical
Parvin Asadi, Mohsen Alvani, Valiollah Hajhashemi, Mahboubeh Rostami, Ghadamali Khodarahmi
Summary: New triazine-based derivatives were synthesized and evaluated for their anti-inflammatory activity, showing promising results as potential anti-inflammatory agents.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Hamed Vakilzadeh, Jaleh Varshosaz, Mohammad Dinari, Mina Mirian, Valiollah Hajhashemi, Nahal Shamaeizadeh, Hamid Mir-mohammad Sadeghi
Summary: Dasatinib (DAS) was conjugated to two molecular weights of chitosan (CHIT) using disulfide bond-containing linker to synthesize CHIT-S-S-DAS amphiphilic conjugates. The resulting redox-responsive micelles showed potential for passive targeting and on-demand drug release for DAS delivery to macrophages. In vitro and in vivo studies demonstrated that the optimized redox-responsive micelles were highly efficient in reducing inflammation and had better therapeutic effects compared to non-redox responsive micelles and free DAS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Omid Hajhashemi, Azadeh Mesripour, Valiollah Hajhashemi
Summary: This study evaluated the effect of vanillic acid (VA) on depression induced by interferon-alpha (IFN-alpha) and cyclosporine A (CSA) in a mice model. The results showed that VA was able to alleviate the depressive symptoms caused by IFN-alpha and CSA.
JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES
(2022)
Article
Clinical Neurology
Valiollah Hajhashemi, Ghadamali Khodarahmi, Parvin Asadi, Hamed Rajabi
Summary: The study demonstrated that both vanillin-triazine and phenylpyrazole-triazine derivatives have an antinociceptive effect. Some compounds showed activity in the early phase of the formalin test and in the hot plate test, indicating their potential in controlling acute pain and chronic/inflammatory pain.
KOREAN JOURNAL OF PAIN
(2022)
Article
Pharmacology & Pharmacy
Somayeh Taymouri, Valiollah Hajhashemi, Majid Tabbakhian, Massoud Torkashvand
Summary: In this study, imatinib-loaded transfersomal gel (imatinib-TFS-Gel) was developed to reduce oral dosing frequency and side effects in rheumatoid arthritis (RA) therapy. The optimized imatinib-TFS formulation showed promising characteristics with improved skin permeation and efficacy in the RA rat model, indicating its potential as a drug delivery system for RA treatment.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Valiollah Hajhashemi, Behzad Zolfaghari, Pooya Amin
Summary: The study evaluated the anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of bark and essential oil of leaves of P. eldarica, finding that they significantly reduced acute and chronic pain as well as inflammation, with a partial involvement of ATP-dependent K+ channels.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2021)
Article
Chemistry, Medicinal
Azadeh Mesripour, Mojgan Golbidi, Valiollah Hajhashemi
RESEARCH IN PHARMACEUTICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Azadeh Mesripour, Andiya Meshkati, Valiollah Hajhashemi
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Immunology
Valiollah Hajhashemi, Samira Rafieian Kopaei, Seyed Ebrahim Sajjadi
IMMUNOPATHOLOGIA PERSA
(2020)
Article
Chemistry, Medicinal
Asie Poorassar, Mohammad Reza Shams Ardekani, Valiollah Hajhashemi, Roja Rahimi, Mehran Mirabzadeh Ardakani, Mohammadreza Aghayeghazvini
RESEARCH IN PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Ali Hosseini-Sharifabad, Sara Naghibzadeh, Valiollah Hajhashemi
RESEARCH IN PHARMACEUTICAL SCIENCES
(2019)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)