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Biochemistry & Molecular Biology
Yuan Fu, Yunran Xu, Yunjun Liu, Yi Wang, Ju Chen, Xiuzhen Wang
Summary: Three benzoxanthone derivatives were synthesized using a new photochemical strategy, and their cytotoxic activity and interaction with DNA were evaluated. The results showed that these compounds induced cell apoptosis through a ROS-mediated mitochondrial dysfunction pathway.
Article
Pharmacology & Pharmacy
Changlun Chen, Yilin Liu, Yi Shen, Lili Zhu, Lumeng Yao, Xingxing Wang, Anna Zhang, Jiao Li, Jianjun Wu, Luping Qin
Summary: Rosmarinic acid (RA) was isolated from Rubi Fructus for the first time and was found to induce apoptosis in SGC-7901 and HepG2 cells through the mitochondrial pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
Jiawen Wang, Haimei Liu, Xiaoyun Wu, Chuanling Shi, Wenlong Li, Yuhan Yuan, Yunjun Liu, Degang Xing
Summary: This study evaluated the anticancer activity of newly synthesized iridium(III) complexes and found that these complexes exhibit significant inhibition of cell proliferation and induction of apoptosis.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2022)
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Cell Biology
Tian-Chuan Li, Nai-Jie Chen, Yun-Ying Chen, Bing-Jing He, Zhi-Feng Zhou
Summary: Solasonine, a steroidal glycoalkaloid from the herbal plant Solanum nigrum Linn., has been found to inhibit the proliferation of human gastric cancer cells by regulating the cell cycle, down-regulating specific protein expression, and inducing apoptosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Yafei Chu, Zheng Xiao, Nan Jing, Wenjuan Yan, Shanmei Wang, Bing Ma, Jiangfeng Zhang, Yi Li
Summary: Arborinine, a natural product from G. parva leaf extracts, shows potential antiproliferative activity against human cervical cancer cells, gastric cancer cells, and drug-resistant gastric cancer cells. It selectively inhibits LSD1 and suppresses epithelial-mesenchymal transition in gastric cancer cells, demonstrating potential as an effective treatment for gastric cancer and adriamycin-resistant gastric cancer. In vivo studies confirm its ability to reduce tumor growth in xenograft mouse models.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Microscopy
Jia-He Wang, Jia-Jia Wang, Tuo-Yu Ju, Yu-Xi Huang, Li-Xin Yuan, Ying-Hui Luo, Yu-Juan Chen, Zuo-Bin Wang
Summary: This study used an atomic force microscope to quantitatively detect the effects of Phellinus linteus on gastric cancer cells. It was found that Phellinus linteus can change the morphology of cells, increase their height and surface roughness, reduce cell adhesion force, and increase the elasticity modulus. However, it has less impact on gastric epithelial cells. These results demonstrate that Phellinus linteus can be used as a preferred anticancer drug for the treatment of gastric cancer cells.
Article
Plant Sciences
Yinglong Cao, Yi Liu, Ge Wang, Wenqiong Wang, Yougui Li, Lijiang Xuan
Summary: Three new compounds were isolated from the sporocarps of Phellinus igniarius, along with seven known compounds. Compounds 4 and 10 were found to induce apoptosis of Hela-/- cells at a dose of 20 μM. This study provides new evidence for the medicinal value of Phellinus igniarius.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Xue Liu, Shiyao Cui, Caiyun Dan, Wenle Li, Hongqing Xie, Conghui Li, Liangen Shi
Summary: This study identified the composition of Phellinus baumii polyphenol (PBP) and investigated its antitumor effects on lung cancer cells. The results showed that PBP induces apoptosis and cell cycle arrest, accumulates reactive oxygen species, and decreases mitochondrial membrane potential in A549 cells, exerting its antitumor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hejuntao Chen, Ting Jiang, Hui Chen, Jingjing Su, Xuncui Wang, Yin Cao, Qinglin Li
Summary: Brusatol, a compound from Brucea javanica, shows potential as an anticancer drug by inhibiting LPS-induced EMT and cell invasion in gastric cancer cells. The study suggests that Brusatol induces apoptosis by deactivating the PI3K/Akt/NF-kappa B signaling pathway, providing a new theoretical basis for gastric cancer treatment.
Article
Biochemistry & Molecular Biology
Rui Wang, Besir Krasniqi, Yang Li, Wim Dehaen
Summary: In this study, triphenylphosphonium-linked derivatives of natural triterpenoid allobetulin were synthesized using 1,2,3-triazole as the linking group. The resulting compound, allobetulin-5, showed excellent anticancer activity by inducing apoptosis through the mitochondrial pathway and inhibiting epithelial-mesenchymal transition.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Shiyong Gao, Huixin Tan, Dan Li
Summary: Statistics from GLOBOCAN show that gastric cancer is the sixth most common cancer and the third highest in terms of mortality in 2020. In China, a herb called Rabdosia rubescens has been traditionally used for the treatment of digestive tract cancer. This study investigates the role of the TNF-alpha/Androgen receptor/TGF-beta signalling pathway in mediating the inhibition of gastric cancer cell proliferation by oridonin.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mengling Lv, Zhouqin Liu, Yuling Tao, Chenlei Jiang, Hong Lu
Summary: This study demonstrated that total flavonoids of Phellinus igniarius (TFPI) exhibited a protective effect against oxidative damage induced by monosodium urate (MSU) in HK-2 cells. The mechanism involved the regulation of reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress to reduce cell apoptosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Li Tian, Yuanyuan Zhang, Huiwen Zhang, Yi Zhou, Wenlong Li, Yuhan Yuan, Jing Hao, Linlin Yang, Yunjun Liu
Summary: The study examined the anticancer effects of two new iridium(III) complexes on SGC-7901 cells, demonstrating their high cytotoxic activity and induction of cell death through the mitochondrial apoptotic pathway. The complexes inhibited cell proliferation and caused cell cycle arrest, indicating their potential as antineoplastic drug candidates.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yehua Li, Baoqiang Fan, Ning Pu, Xue Ran, Tiancheng Lian, Yifan Cai, Wei Xing, Kun Sun
Summary: The study demonstrates that isorhamnetin (ISO) induces apoptosis in gastric cancer cells through the mitochondria-dependent apoptotic pathway, inhibiting cell proliferation and providing a potential strategy for clinical therapy.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)