Review
Endocrinology & Metabolism
Priyanka Ramesh, Rahul Jagadeesan, Saravanan Sekaran, Anuradha Dhanasekaran, Selvaraj Vimalraj
Summary: Flavonoids are polyphenolic compounds found in various natural products with multiple applications, including anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, as well as the ability to stimulate bone formation. They influence bone remodelling through various signaling pathways and play a crucial role in maintaining bone integrity and structure. Their effects on regulating angiogenesis, decreasing inflammatory cytokine levels, and scavenging reactive oxygen species further underscore their potential as a promising agent in treating bone-related ailments in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ece Guler, Yaren Ezgi Baripoglu, Hussain Alenezi, Ayca Arikan, Ravana Babazade, Semra Unal, Gokhan Duruksu, Fawzan S. Alfares, Yusufhan Yazir, Faik Nuzhet Oktar, Oguzhan Gunduz, Mohan Edirisinghe, Muhammet Emin Cam
Summary: DKMF, loaded with Vitamin D3, Vitamin K2, and Mg, demonstrated osteoinductive effects by activating the Wnt/beta-catenin signaling pathway and promoting the growth and function of osteoblast cells, making it a promising treatment approach in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agricultural Engineering
Chotiwit Sriwong, Suwimon Boonrungsiman, Prakit Sukyai
Summary: Biocomposite cellulose-based scaffolds combined with hydroxyapatite were successfully developed from sugarcane bagasse for tissue engineering. The scaffolds showed appropriate porosity and low degradation rate. Cell viability, proliferation, and differentiation experiments demonstrated that the cellulose combined HA scaffolds promoted the growth and differentiation of bone cells. The results indicated that sugarcane bagasse-derived cellulose is an ideal material for bone scaffolding applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
Yamei Xu, Yao Yang, Ziyi Hua, Shuang Li, Zhenyu Yang, Qianzi Liu, Gang Fu, Ping Ji, Qingqing Wu
Summary: The BMP2 antibody shows promise as a replacement for rhBMP2 in bone tissue engineering, promoting bone formation and suppressing osteoclastogenesis. Further research is needed to clarify the specific osteogenic mechanism and adverse reactions associated with the antibody.
Article
Engineering, Biomedical
Daniela Medrano-David, Aura Maria Lopera, Martha Elena Londono, Pedronel Araque-Marin
Summary: The study developed an injectable bone substitute (IBS) with great potential for bone tissue regeneration, by incorporating DBM into a PVA/glycerol network cross-linked with borax and reinforced with CaCO3. The material showed good bioactivity and physicochemical properties suitable for bone tissue regeneration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
Article
Chemistry, Applied
Baharak Divband, Marziyeh Aghazadeh, Zahraa Haleem Al-qaim, Mohammad Samiei, Falah H. Hussein, Alireza Shaabani, Shahriar Shahi, Roya Sedghi
Summary: Injectable hydrogels loaded with VEGF and BMP-2 promote proliferation and osteogenic differentiation of DPSCs, showing potential for bone defect treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Jun Wu, Linjun Jiang, Lingpeng Ju, Yuan Zhang, Ming Li, Xing Liu, Xiangyang Qu
Summary: This study successfully combined bone morphogenetic protein-9 (BMP-9) with deproteinized osteoarticulation (DPOA) to achieve excellent osteogenic and angiogenic effects in a canine femoral condylar defect model, demonstrating outstanding osteoarticular repair outcomes.
MATERIALS & DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Ashwathi Vijayalekha, Suresh Kumar Anandasadagopan, Ashok Kumar Pandurangan
Summary: Bone regeneration is a complex physiological process that occurs throughout a person's life. Current bone repair methods have limitations, while tissue engineering offers potential for repairing damaged tissue. Collagen-based biomaterials, particularly collagen type I, play a crucial role in bone tissue engineering.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I. Idris
Summary: Research on the modulation of CB1 and CB2 receptors on bone metabolism has shown that the results are confounded by the heterogeneity of models and the low number of studies.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Engineering, Biomedical
Leanne de Silva, Paulina N. Bernal, A. J. W. Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Summary: The development of tissue engineering strategies for treatment of large bone defects is crucial, and creating a vascular network is vital for tissue engineered bone constructs.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Katarzyna Klimek, Krzysztof Palka, Wieslaw Truszkiewicz, Timothy E. L. Douglas, Aleksandra Nurzynska, Grazyna Ginalska
Summary: This study aimed to evaluate the potential application of curdlan/whey protein isolate/hydroxyapatite biomaterials in bone tissue engineering and investigate the influence of whey protein isolate concentration on their properties. The results showed that the biomaterials exhibited some desirable characteristics for bone scaffolds, but their porosity and mechanical properties need to be improved.
Article
Biotechnology & Applied Microbiology
Sebastian Blatt, Daniel G. E. Thiem, Solomiya Kyyak, Andreas Pabst, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The combination of PRF with different BSM increases initial cell viability and may influence early proliferation and migration potential of osteoblasts via factors such as RUNX2, alkaline phosphatase, collagen, and BMP2, especially when combined with alloplastic and xenogeneic BSM. Biofunctionalization of BSM using PRF might improve bone formation and expand the range of indications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Jinglun Zhang, Qian Wu, Chengcheng Yin, Xiaoshi Jia, Zifan Zhao, Xiaoxin Zhang, Guohua Yuan, Hao Hu, Qin Zhao
Summary: Studies have shown that biphasic calcium phosphate (BCP) has strong osteoinductive properties in bone regeneration, primarily by promoting M2 macrophage polarization and the differentiation of mesenchymal stem cells into osteoblasts. The released Ca2+ from BCP activates M2 macrophages through the CaSR pathway, thus promoting bone regeneration.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
I Yuste, F. C. Luciano, E. Gonzalez-Burgos, A. Lalatsa, D. R. Serrano
Summary: Understanding the biology and behavior of human osteoblasts in vitro is crucial for developing research models that replicate bone structure and interactions accurately. Mimicking the bone microenvironment is challenging yet essential for clinical translation of novel medicines. Advanced technologies like 3D bioprinting and microfluidics bridge the gap between in vitro and in vivo models.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Materials Science, Ceramics
Raj Kumar Samudrala, Sushil Patel, Vasudevarao Penugurthi, Bramanandam Manavathi, P. Abdul Azeem
Summary: The study focused on examining in vitro studies of a novel bioactive glass system, B2O3-SiO2-Na2O-CaO-ZnO, using ISO standards. Bioactivity and cytocompatibility were studied, with the zinc-containing glass showing significant results for bone tissue engineering applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Chemistry, Multidisciplinary
Saleh Alshammari, Mohammed Al-Smadi, Ishak Hashim, Mohd Almie Alias
APPLIED SCIENCES-BASEL
(2019)
Article
Engineering, Biomedical
Mohd Almie Alias, Pascal R. Buenzli
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2020)
Article
Health Care Sciences & Services
Siti Shaliza Mohd Khairi, Mohd Aftar Abu Bakar, Mohd Almie Alias, Sakhinah Abu Bakar, Choong-Yeun Liong, Nurwahyuna Rosli, Mohsen Farid
Summary: This study explores the research status and development trends of deep learning on breast cancer image classification through bibliometric analysis. The study finds a stable growth in this field and analyzes author collaborations and potential future directions.
Article
Mathematics, Applied
Saleh Alshammari, Mohammed Al-Smadi, Mohammad Al Shammari, Ishak Hashim, Mohd Almie Alias
INTERNATIONAL JOURNAL OF DIFFERENTIAL EQUATIONS
(2019)
Article
Environmental Sciences
Nur Fariha Syaqina Zulkepli, Mohd Salmi Md Noorani, Fatimah Abdul Razak, Munira Ismail, Mohd Almie Alias
AEROSOL AND AIR QUALITY RESEARCH
(2019)
Article
Biophysics
Mohd Almie Alias, Pascal R. Buenzli
BIOPHYSICAL JOURNAL
(2017)