Journal
BIOMATERIALS
Volume 157, Issue -, Pages 17-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.12.001
Keywords
Selenium; Platinum; Anticancer; Self-assembly; Coordination
Funding
- National Science Foundation for Distinguished Young Scholars [21425416]
- National Natural Science Foundation of China [91427301]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21421064]
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It is urgently desired that self-assembly methods can be used to develop smart nanomedicines with adjustable anticancer activity and concise structure. Herein, we design carrier-free small molecule assemblies of platinum coordinated selenomethionine, which exhibit adjustable anticancer activity regulated by their self-assembly behaviors. The small molecule assemblies are prepared by coordination of selenomethionine esters with cisplatin. Their self-assembly behaviors can be tuned by esterification between selenomethionine and alcohols with different alkyl lengths, which results in adjustable anticancer activities. The coordination assemblies exhibit high anticancer activity as well as low side effects. Mechanistic studies indicate that they can consume glutathione (GSH) and therefore induce high level of reactive oxygen species (ROS) in cancer cells, which further lead to cell apoptosis. Our findings provide new strategies and insights in developing small molecule assemblies for cancer treatment. (C) 2017 Elsevier Ltd. All rights reserved.
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