Article
Biochemistry & Molecular Biology
Daniel G. Henriques, Renan Lyra Miranda, Romulo Sperduto Dezonne, Luiz Eduardo Wildemberg, Aline Helen da Silva Camacho, Leila Chimelli, Leandro Kasuki, Elisa B. Lamback, Alexandro Guterres, Monica R. Gadelha
Summary: This study identified miRNAs associated with resistance to fg-SRLs treatment in acromegaly using miRNA sequencing and bioinformatic analysis. It was found that miR-181a-5p, miR-181b-5p, and miR-383-5p were differentially expressed, with miR-181a-5p and miR-181b-5p downregulated and miR-383-5p upregulated in the uncontrolled group. ROC curve analysis showed that miR-383-5p had an NPV of 84.3% and a PPV of 84.5%. Thus, these miRNAs can serve as biomarkers and tools to guide clinical decisions in response to fg-SRLs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Li Zuo, Xiaoli Li, Hailong Zhu, Anqi Li, Yonggang Wang
Summary: Detection of miR-181a in circulating tumor cells (CTCs) of ovarian cancer patients may allow for early diagnosis and prognostic evaluation. MiR-181a could be involved in the development and progression of ovarian cancer as an oncogene. The expression of miR-181a in CTCs captured by EpCAM liposome magnetic beads (Ep-LMBs) correlates with clinical characteristics of ovarian cancer.
Article
Oncology
Qi Zhang, Changli Wang, Ruijia Li, Jingjing Liu, Jiyu Wang, Tianyi Wang, Bing Wang
Summary: BAP31 regulates colorectal cancer (CRC) angiogenesis by manipulating the tumor microenvironment. Exosomes from BAP31-overexpressing CRCs induce the transformation of normal fibroblasts into proangiogenic cancer-associated fibroblasts (CAFs). Moreover, miR-181a-5p, a microRNA present in the exosomes, directly targets the RECK gene and promotes endothelial cell angiogenesis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Yuefeng Chen, Xinnan Pan, Baoming Tian, Yajun Hu
Summary: Polysaccharides have various biological activities, including tumor suppression by regulating the polarization of tumor-associated macrophages. In this study, the correlation between CD24 expression and colorectal cancer (CRC) was investigated. The results showed that CD24 expression was significantly correlated with advanced nuclear grade, lymph node metastasis, Duke's stage, and age of CRC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Review
Oncology
Jie He, Wei Luo, Yuanyuan Huang, Lingmeng Song, Yang Mei
Summary: This study aimed to evaluate the promise of sarcopenia as a prognostic indicator in individuals with colorectal cancer. Through systematic search and analysis of the literature, it was found that sarcopenia is associated with survival rates and disease-free survival rates in colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Tong Liu, Duo Liu, Shangwei Guan, Mei Dong
Summary: This meta-analysis found that circulating miR-21 has moderate sensitivity and good specificity in CRC diagnosis, indicating its potential diagnostic value.
ANNALS OF MEDICINE
(2021)
Review
Oncology
Junxin Li, Jing Shen, Yueshui Zhao, Fukuan Du, Mingxing Li, Xu Wu, Yu Chen, Shurong Wang, Zhangang Xiao, Zhigui Wu
Summary: miR-181a-5p is an important miRNA that can post-transcriptionally suppress targeted genes and is associated with various diseases. It plays a regulatory role in different types of cancer, potentially serving as a diagnostic and prognostic biomarker and influencing chemoresistance.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Paola Del Prete, Francesco Perri, Stefania Scala, Michele Caraglia, Guglielmo Nasti
Summary: High expression of CXCR4 is clearly associated with increased risk of death and progression in colorectal cancer. However, methodologic heterogeneity in CXCR4 assessment hinders direct translation into clinical practice, indicating the need for a consensus to streamline detection and scoring of CXCR4 expression in colorectal cancer.
Review
Oncology
Minghao Cai, Zhongyan Gao, Junyi Liao, Yuanping Jiang, Yong He
Summary: The study found that regardless of differences in frailty screening and treatment approaches, outcomes for frailty patients were less favorable in all studies. Compared with the non-frail group, the frail group had higher mortality, more serious complications, more postoperative blood transfusions and delirium, and more support outside the home.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yimei Jiang, Qingqing Qiu, Xiaoqian Jing, Zijia Song, Yaqi Zhang, Changgang Wang, Kun Liu, Feng Ye, Xiaopin Ji, Fangxiu Luo, Ren Zhao
Summary: The tumor microenvironment plays a crucial role in the development of colorectal cancer (CRC). This study demonstrates that tumor-associated fibroblasts (CAFs) release exosomes containing miR-181b-3p, which promote CRC progression by regulating SNX2 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Jianjie Li, Xiaoyue Xu, Chunhui Liu, Xiaoxue Xi, Yang Wang, Xiaotang Wu, Hua Li
Summary: miR-181a-2-3p promotes GC cell progression by targeting MYLK and enhancing tumor growth. The promoting effect of miR-181a-2-3p on GC cells is reversed when miR-181a-2-3p and MYLK are simultaneously overexpressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Lixia Hu, Mengqin Huang, Qianqian Yuan, Fanliang Kong
Summary: This meta-analysis suggests that low miR-638 expression is associated with poor prognosis in cancer patients, particularly in those with digestive system cancers. Additionally, low miR-638 expression is correlated with clinical features such as tumor size, lymph node metastasis, and TNM stage.
Article
Multidisciplinary Sciences
Mi-Kyoung Seo, Hyundeok Kang, Sangwoo Kim
Summary: This study developed a novel method to predict microsatellite instability (MSI) in colorectal cancer (CRC) using transcriptomic profile and tumor microenvironment (TME). The method showed robustness and predictive power in predicting MSI status and has additional advantages compared to existing classifiers and other cancer types.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yingying Zhang, Siying He, Lisha Yu, Chao Shi, Yanyue Zhang, Shiyue Tang
Summary: This meta-analysis aimed to evaluate the prognostic value of HLA-G in colorectal cancer (CRC) patients based on published literature and The Cancer Genome Atlas (TCGA) datasets. The results showed that HLA-G expression was significantly associated with poor overall survival in CRC patients. However, the prognostic significance was inconsistent with the TCGA data. Further research is needed to clarify the prognostic role of HLA-G in CRC.
