Journal
BIOMACROMOLECULES
Volume 19, Issue 8, Pages 3427-3434Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.8b00744
Keywords
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Funding
- University of Warwick
- Lubrizol Corporation
- Royal Society
- ERC
- Helms Fellowship
- National Science Foundation [BMAT-1507420]
- Knight Foundation
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Polymeric nanoparticles are widely investigated to enhance the selectivity of therapeutics to targeted sites, as well as to increase circulation lifetime and water solubility of poorly soluble drugs. In contrast to the encapsulation of the cargo into the nanostructures, the conjugation directly to the polymer backbone allows better control on the loading and selective triggered release. In this work we report a simple procedure to create biodegradable polycarbonate graft copolymer nanoparticles via a ring opening polymerization and subsequent postpolymerization modification strategies. The polymer, designed with both pH-responsive acetal linkages and a norbornene group, allows for highly efficient postpolymerization modifications through a range of chemistries to conjugate imaging agents and solubilizing arms to direct self-assembly. To demonstrate the potential of this approach, polycarbonate-based nanoparticles were tested for biocompatibility and their ability to be internalized in A549 and IMR-90 cell lines.
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