Journal
BIOMACROMOLECULES
Volume 19, Issue 2, Pages 386-391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.7b01479
Keywords
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2016R1A2B2016148]
- NRF - Korea government (MSIP) [20080061891]
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Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a microshell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively cross-link them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets. A model micromechanic study, carried out in an artificial blood vessel, demonstrates that the extraordinary degradation kinetics of the GMPs, which stems from the microshell structure, enables controlled rupturing while exhibiting drug release under temporary chemoembolic conditions
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