Article
Biotechnology & Applied Microbiology
Ran Ji, Yifei Ji, Lin Ma, Sijia Ge, Jing Chen, Shuzhen Wu, Tianxin Huang, Yu Sheng, Liyang Wang, Nan Yi, Zhaoxiu Liu
Summary: The study revealed that high expression of KRT17 can promote cell metastasis and angiogenesis of colon cancer cells by regulating the WNT/beta-catenin signaling pathway, indicating KRT17 as a potential therapeutic target for COAD treatment.
Article
Cell Biology
Bing Tu, Bo Yu, Wei Wang, Juehong Li, Feng Yuan, Jing Zhu, Cunyi Fan
Summary: IL-17 promotes traumatic heterotopic ossification by activating beta-catenin signaling, while inhibition of IL-17 may serve as a potential therapeutic target for traumatic HO.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Karema Abu-Elfotuh, Ghada M. Ragab, Ahmad Salahuddin, Lubna Jamil, Ekram Nemr Abd Al Haleem
Summary: The study found that aluminum elevated liver and kidney enzymes and caused over-production of oxidative stress and inflammatory markers. Treating AD groups with fluoxetine, wheatgrass, or a combination alleviated these toxic insults. Additionally, fluoxetine and wheatgrass combination showed a more significant neuroprotective impact in treating AD than fluoxetine alone, with protective effects on liver and kidney tissues.
Article
Biochemistry & Molecular Biology
S. Zachary Swartz, Tzer Han Tan, Margherita Perillo, Nikta Fakhri, Gary M. Wessel, Athula H. Wikramanayake, Iain M. Cheeseman
Summary: In meiotic oocytes of the sea star Patifia miniata, the distribution dynamics of the Disheveled protein are regulated by meiotic cell cycle progression and influenced by association with Lamp1+ endosomes and pre-localized Frizzled receptors within the oocyte cortex.
Article
Agriculture, Dairy & Animal Science
Firdevs Binli, Ipek Inan, Fatih Buyukbudak, Aykut Gram, Duygu Kaya, Narin Liman, Selim Aslan, Murat Findik, Serhan Serhat Ay
Summary: The study aimed to investigate the effect of trilostane on pregnancy termination in dogs. The results showed that trilostane treatment alone was not effective in terminating pregnancy, while aglepristone treatment resulted in 100% pregnancy termination. Additionally, the decrease in fetal heart rates was significantly lower in the trilostane and aglepristone groups compared to the control group, and there was a marked decrease in serum P4 concentrations in the trilostane group.
Article
Obstetrics & Gynecology
Chaitali Ghosh, Ratnabali Maity, Aaishi Roy, Chhanda Mallick
Summary: This study aimed to find the most effective dose of Hygrophila auriculata extract to improve male subfertility induced by cyproterone acetate (CPA). Rats were made subfertile by administrating CPA for 45 days, resulting in low sperm concentration and reduced hormone levels. Treatment with Hygrophila auriculata extract at different doses showed significant recovery in sperm count and hormone levels. CPA also generated oxidative free radicals and affected gene expression, but these effects were reversed by the extract. The 5 mg dose was found to be the minimum therapeutic dose to recover CPA-induced subfertility.
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fen Ji, Chao Feng, Jie Qin, Chong Wang, Dongming Zhang, Libo Su, Wenwen Wang, Mengtian Zhang, Hong Li, Longbing Ma, Weicheng Lu, Changmei Liu, Zhaoqian Teng, Baoyang Hu, Fengzeng Jian, Jingdun Xie, Jianwei Jiao
Summary: The deletion of Pd1 in the brain leads to abnormal cortical neurogenesis and depressive-like behaviors. Pd1 regulates neurogenesis by targeting Pax3 through the β-catenin signaling pathway. Furthermore, Pd1 also plays a similar role in the proliferation and differentiation of human neural progenitor cells (hNPCs).
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Ankur Singh, Bechan Lal, Jyoti Parkash, Robert P. Millar
Summary: The study shows that kisspeptin-10 stimulates gametogenesis in catfish by enhancing gonadal steroid production. It describes the cascade of steroidogenic actions of kisspeptin-10 in the catfish and suggests that kisspeptin may act locally to regulate gonadal activities in an autocrine/paracrine manner independently of known extra-gonadal factors.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Environmental Sciences
Xiaoli Chen, Liyan Gu, Xia Chen, Jianping Xing, Chengxia Zhang
Summary: The study showed that miR-17-5p is upregulated in DN patients and high glucose-treated HMCs. Silencing miR-17-5p reduces apoptosis and fibrosis in HMCs. MiR-17-5p binds to KIF23 and negatively regulates its expression, impacting Wnt/beta-catenin signaling in HMCs.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Hemangini A. Dhaibar, Hemant Patadia, Tabassum Mansuri, Ritu Shah, Laxmichand Khatri, Hiral Makwana, Samip Master, Pushpa Robin
Summary: Exposure to hexachlorobenzene leads to hypothyroidism, affecting reproductive ability and growth in rats. Supplementing thyroxine can rescue reproductive abnormalities, highlighting the protective role of the thyroid in reproductive biology.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Aysenur Gok, Aynur Isik, Sinem Bakir, Sarp Uzun, Gunes Guner, Ozge Ozcan, Baris Cerci, Ilyas Onbasilar, Aytekin Akyol
Summary: This study examined the effects of reduced Bdnf levels in an Apc mutant intestinal/colonic tumor mouse model. The results showed that Bdnf mutant and Apc/Bdnf double mutant mice had a significant weight gain compared to controls. The small intestine polyp count decreased slightly in Apc/Bdnf double mutant mice, while the colon polyp count increased significantly.
Article
Oncology
Sofia Xanthoulea, Gonda F. J. Konings, Niina Saarinen, Bert Delvoux, Loes F. S. Kooreman, Pasi Koskimies, Merja R. Hakkinen, Seppo Auriola, Elisabetta D'Avanzo, Youssef Walid, Frank Verhaegen, Natasja G. Lieuwes, Florian Caiment, Roy Kruitwagen, Andrea Romano
Summary: The study demonstrates that pharmacological inhibition of 17β-HSD-1 can inhibit the development of endometrial cancer. Through experiments on mice, it was found that treatment with the inhibitor significantly reduces tumor growth and metastatic spread.
Article
Plant Sciences
Nishit Patel, Priyal Patel, Piyush Chudasama, Samir Patel, Manan Raval
Summary: This study found that the roots of Argyreia nervosa can promote testosterone biosynthesis and spermatogenesis. This may be achieved by increasing the activity and mRNA expression of enzymes related to biosynthesis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Kang Xiao, Xi Wang, Wen-Bin Liu, Ding-Dong Zhang, Xiang-Fei Li, Chun-Nuan Zhang, Wei-Hua Chen, Kenneth Prudence Abasubong, Guang-Zhen Jiang
Summary: In this study, the levels of serum corticosterone, cortisol, and glucose were measured to evaluate the responses of fish to seven common stressors. The results showed that corticosterone and cortisol exhibited different patterns of dynamic changes, and glucose levels were influenced by both hormones. Corticosterone seemed to respond to stress earlier than cortisol and together they regulated glucose levels to cope with stress.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mai O. Kadry, Rehab M. Abdel-Megeed
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Mai O. Kadry, Hanaa Mahmoud Ali
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2017)
Article
Cell Biology
Rehab M. Abdel-Megeed, Ahmed R. Hamed, Azza A. Matloub, Mai O. Kadry, Abdel-Hamid Z. Abdel-Hamid
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Rehab M. Abdel Megeed, Dalia B. Fayed, Amira Abood, Mai O. Kadry
SAUDI PHARMACEUTICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Maha Z. Rizk, Sanaa A. Ali, Mai O. Kadry, Ghadah Fouad, Nahla N. Kamel, Eman A. Younis, Samar M. Gouda
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Sohair Aly Hassan, Mai O. Kadry
Summary: This study revealed significant biochemical alterations induced by AlCl3 in the brain, liver, and kidney, including oxidative damage and changes in protein expressions, which may contribute to the development of various diseases.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sanaa A. Ali, Azza F. Arafa, Hanan F. Aly, Nabaweya A. Ibrahim, Mai O. Kadry, Rehab M. Abdel-Megeed, Manal A. Hamed, Ayman A. Farghaly, Nagy S. El Regal, Ghada Fouad, Wagdy K. B. Khalil, Esraa A. Refaat
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Biotechnology & Applied Microbiology
Mai O. Kadry, Naglaa M. Ammar, Heba A. Hassan, Rehab M. Abdel Megeed
Summary: This study found that liposomal turmeric can prevent acute toxicity induced by methotrexate through regulation of autophagy, antioxidation, and anti-apoptosis.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Toxicology
Rehab M. Abdel-Megeed, Sameh H. Abd El-Alim, Azza F. Arafa, Azza A. Matloub, Abd El Razik H. Farrag, Asmaa B. Darwish, Abdel-Hamid Z. Abdel-Hamid, Mai O. Kadry
TOXICOLOGY REPORTS
(2020)
Article
Endocrinology & Metabolism
Rehab M. Abdel-Megeed, Samah A. El Newary, Mai O. Kadry, Hassan Z. Ghanem, Rabeh A. El-Shesheny, Hussein A. H. Said-Al Ahl, Abdel-Hamid Z. Abdel-Hamid
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Article
Toxicology
Rehab M. Abdel-Megeed, Mai O. Kadry, Dalia B. Fayed, Abdel-Hamid Z. Abdel-Hamid
TOXICOLOGY REPORTS
(2019)
Article
Multidisciplinary Sciences
Mai O. Kadry
Article
Cardiac & Cardiovascular Systems
Mai O. Kadry, Rehab M. Abdel-Megeed
CARDIOVASCULAR TOXICOLOGY
(2018)
Article
Toxicology
Mai O. Kadry, Rehab M. Abdel-Megeed, Emad El-Meliegy, Abdel-Hamid Z. Abdel-Hamid
TOXICOLOGY REPORTS
(2018)