The function of sphingomyelinases in mycobacterial infections

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Crystal structure of mammalian acid sphingomyelinase

(2016) Alexei Gorelik et al.   Nature Communications

The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages

(2016) Cristina L. Vázquez et al.   Scientific Reports

Co-option of Membrane Wounding Enables Virus Penetration into Cells

(2015) Stefania Luisoni et al.   Cell Host & Microbe

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

(2015) A. Carpinteiro et al.   EMBO Molecular Medicine

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

(2015) Huiming Peng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Update on the epidemiology, diagnosis, and treatment of leprosy

(2015) F. Reibel et al.   MEDECINE ET MALADIES INFECTIEUSES

Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion ofNeisseria gonorrhoeae

(2014) Michaela Faulstich et al.   CELLULAR MICROBIOLOGY

NF- B Activation Controls Phagolysosome Fusion-Mediated Killing of Mycobacteria by Macrophages

(2014) M. G. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa-Induced Macrophage Apoptosis

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

In search of a new paradigm for protective immunity to TB

(2014) Cláudio Nunes-Alves et al.   NATURE REVIEWS MICROBIOLOGY

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells

(2014) Alexander Simonis et al.   PLoS Pathogens

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

Leishmania-Induced Biphasic Ceramide Generation in Macrophages Is Crucial for Uptake and Survival of the Parasite

(2012) Saikat Majumder et al.   JOURNAL OF INFECTIOUS DISEASES

Role of CD95 in pulmonary inflammation and infection in cystic fibrosis

(2012) Katrin Anne Becker et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ebolavirus Requires Acid Sphingomyelinase Activity and Plasma Membrane Sphingomyelin for Infection

(2012) M. E. Miller et al.   JOURNAL OF VIROLOGY

Propionibacterium acnes CAMP Factor and Host Acid Sphingomyelinase Contribute to Bacterial Virulence: Potential Targets for Inflammatory Acne Treatment

(2011) Teruaki Nakatsuji et al.   PLoS One

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells

(2011) Elita Avota et al.   PLoS Pathogens

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

(2010) A. Wahe et al.   JOURNAL OF CELL SCIENCE

Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection

(2010) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

The immunology of tuberculosis: From bench to bedside

(2010) Keertan DHEDA et al.   RESPIROLOGY

Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

(2010) P. Muenzner et al.   SCIENCE

Defective Acid Sphingomyelinase Pathway withPseudomonas aeruginosaInfection in Cystic Fibrosis

(2009) Hong Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Induction of Membrane Ceramides: A Novel Strategy to Interfere with T Lymphocyte Cytoskeletal Reorganisation in Viral Immunosuppression

(2009) Evelyn Gassert et al.   PLoS Pathogens

Ceramide-enriched membrane domains—Structure and function

(2008) Yang Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acid sphingomyelinase is required for efficient phago-lysosomal fusion

(2008) Michael Schramm et al.   CELLULAR MICROBIOLOGY

Fusogenicity of membranes: The impact of acid sphingomyelinase on innate immune responses

(2008) Olaf Utermöhlen et al.   IMMUNOBIOLOGY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens