The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2

(2017) Marian Blanca Ramírez et al.   HUMAN MOLECULAR GENETICS

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons

(2017) Ping-Yue Pan et al.   JOURNAL OF NEUROSCIENCE

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

(2017) Maria Dolores Perez Carrion et al.   Scientific Reports

The unconventional G-protein cycle of LRRK2 and Roco proteins

(2016) S. Terheyden et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening

(2015) Nicholas J. Lavalley et al.   HUMAN MOLECULAR GENETICS

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

(2013) Evy Lobbestael et al.   BIOCHEMICAL JOURNAL

Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations

(2013) Roy N. Alcalay et al.   MOVEMENT DISORDERS

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

(2011) Philip J. Webber et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

(2011) Elizabeth A. Doggett et al.   JOURNAL OF NEUROCHEMISTRY

Milestones in PD genetics

(2011) Thomas Gasser et al.   MOVEMENT DISORDERS

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Parkinson's disease: insights from pathways

(2010) M. R. Cookson et al.   HUMAN MOLECULAR GENETICS

The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

(2009) Elisa Greggio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Investigation of leucine-rich repeat kinase 2

(2008) Vasanti S. Anand et al.   FEBS Journal

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY