Journal
BIOINFORMATICS
Volume 34, Issue 24, Pages 4315-4317Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bty531
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Funding
- National Cancer Institute [R01CA178383, R01CA180006, 5U24CA10972-02, 5U24CA211006-02]
- National Human Genome Research Institute [U01HG006517, 1R01HG009711-01]
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A database of curated genomic variants with clinically supported drug therapies and other oncological annotations is described. The accompanying web portal provides a search engine with two modes: one that allows users to query gene, cancer type, variant type or position for druggable mutations, and another to search for and to visualize, on three-dimensional protein structures, putative druggable sites that cluster with known druggable mutations.
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