Interleukin-1 Blockade in Cardiovascular Diseases: From Bench to Bedside

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

(2018) Paul M Ridker et al.   LANCET

Interleukin-1 Beta as a Target for Atherosclerosis Therapy

(2017) Peter Libby   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Residual inflammatory risk: addressing the obverse side of the atherosclerosis prevention coin

(2016) Paul M Ridker   EUROPEAN HEART JOURNAL

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial

(2016) Ola Kleveland et al.   EUROPEAN HEART JOURNAL

Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance

(2016) Robin P. Choudhury et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fungal Infections and New Biologic Therapies

(2016) Snigdha Vallabhaneni et al.   Current Rheumatology Reports

Comparative Safety of Interleukin-1 Blockade With Anakinra in Patients With ST-Segment Elevation Acute Myocardial Infarction (from the VCU-ART and VCU-ART2 Pilot Studies)

(2015) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

The Inflammasome in Myocardial Injury and Cardiac Remodeling

(2015) Stefano Toldo et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution?

(2014) A. Abbate et al.   EUROPEAN HEART JOURNAL

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

(2014) A. C. Morton et al.   EUROPEAN HEART JOURNAL

Interleukin-1β Reduces L-type Ca2+Current through Protein Kinase Cϵ Activation in Mouse Heart

(2014) Nabil El Khoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1β Blockade Improves Left Ventricular Systolic/Diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse

(2014) Stefano Toldo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inotropes

(2014) Gary S. Francis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction

(2014) Ignacio M. Seropian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Unknown

(2014) Laura O’Brien et al.   MOLECULAR MEDICINE

Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]

(2013) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Targeting Interleukin-1 in Heart Disease

(2013) Benjamin W. Van Tassell et al.   CIRCULATION

Interleukin-1β induces a reversible cardiomyopathy in the mouse

(2013) Benjamin W. Van Tassell et al.   INFLAMMATION RESEARCH

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

(2012) Paul M Ridker et al.   CIRCULATION

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse

(2012) Stefano Toldo et al.   EXPERIMENTAL PHYSIOLOGY

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

(2012) Benjamin W. Van Tassell et al.   PLoS One

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse

(2011) Antonio Abbate et al.   PLoS One

Integrated safety in tocilizumab clinical trials

(2011) Michael H Schiff et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

(2009) Janet Chamberlain et al.   PLoS One

ST2 and Adrenomedullin in Heart Failure

(2009) Rahul Kakkar et al.   Heart Failure Clinics

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE