Article
Biotechnology & Applied Microbiology
Lana L. Elkins, Maureen C. Dolan
Summary: Aquaculture is a sustainable solution as wild caught fisheries decline, but disease management remains challenging. IL-22 is a potential therapeutic target for fish and plant-based production systems offer advantages like low cost and reduced environmental impact.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Allergy
Hesam Movassagh, Mary Prunicki, Abhinav Kaushik, Xiaoying Zhou, Diane Dunham, Eric M. M. Smith, Ziyuan He, German R. Aleman R. Muench, Minyi Shi, Annika K. K. Weimer, Shu Cao, Sandra Andorf, Amir Feizi, Michael P. P. Snyder, Pejman Soroosh, Elizabeth D. D. Mellins, Kari C. C. Nadeau
Summary: This study found that exposure to fine particulate matter (PM2.5) leads to specific alterations in monocytes, especially in children with asthma. Further mechanistic research revealed that fine particulate matter induces innate trained immunity in circulating monocytes, resulting in an enhanced inflammatory response. These findings suggest that the alterations of monocytes may serve as an immune signature for pediatric asthma, and pollution-induced trained immunity could be a potential therapeutic target for asthmatic children.
Letter
Medicine, General & Internal
Theoharis C. Theoharides, Irene Tsilioni
Summary: The article points out that mast cells, as a unique tissue immune cell, can orchestrate the immune response by secreting proinflammatory molecules. It highlights the degranulation of mast cells in the lungs of deceased patients with severe Covid-19, as well as the elevated levels of mast cell-derived proteolytic enzymes in patients' serum.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Respiratory System
Hugo Farne, Lijing Lin, David J. Jackson, Magnus Rattray, Angela Simpson, Adnan Custovic, Shilpy Joshi, Paul A. Wilson, Rick Williamson, Michael R. Edwards, Aran Singanayagam, Sebastian L. Johnston
Summary: This study found dysregulation of innate antiviral responses in asthma, indicating that prophylactic interferon therapy may have greater clinical benefit than therapeutic interferon therapy.
Article
Allergy
Bilal Alashkar Alhamwe, Zhan Gao, Fahd Alhamdan, Hani Harb, Matthieu Pichene, Abel Garnier, Jihad El Andari, Andreas Kaufmann, Peter L. Graumann, Dorthe Kesper, Christian Daviaud, Holger Garn, Joerg Tost, Daniel P. Potaczek, Martin J. Blaser, Harald Renz
Summary: This research identifies a novel mechanism by which early-life exposure to Acinetobacter lwoffii (AL) can prevent chronic inflammatory diseases such as asthma. The study found that AL triggers a proinflammatory immune response characterized by elevated levels of IL-6 and subsequent IL-10 production in CD4(+) T-cells. This immune response, along with changes in the gastrointestinal microbiome, contribute to the protection against asthma.
Article
Immunology
Manish Grover, Michael K. Fasseas, Clara Essmann, Kenneth Liu, Christian Braendle, Marie-Anne Felix, Sally L. Glockling, Michalis Barkoulas
Summary: Oomycetes are a group of eukaryotic organisms, with the Haptoglossa genus characterized by specialized gun cells carrying a harpoon-like infection apparatus. In this study, it was found that Haptoglossa species are potent natural pathogens of Caenorhabditis nematodes, causing excessive tissue degradation upon entry in the body cavity while leaving the host cuticle intact. The host transcriptional response to Haptoglossa infection shares similarities with the response against the oomycete Myzocytiopsis humicola, with induction of chitinase-like genes in the hypodermis being a key example of this shared feature.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Cell Biology
Michelle L. Bland
Summary: In Drosophila melanogaster, the Toll and Imd signaling pathways are activated to combat pathogenic microbes and induce metabolic changes in the host. These immune-mediated metabolic phenotypes can either confer resistance or susceptibility to infection, and are influenced by variables such as sex, diet, and pathogen characteristics. Understanding the mechanisms by which the immune system regulates metabolism is a key focus for future research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Microbiology
Jiaqi Wang, Xiaolei Liu, Ruohang Sun, Hanhai Mao, Mingyuan Liu, Xuemin Jin
Summary: This study investigates the relationship between gut microbiota and cardiac fibrosis using a mouse model infected with Trichinella spiralis. The research reveals that depleting the microbiota with antibiotics worsens the disease phenotype, while fecal microbiota transplantation improves helminth-induced cardiac fibrosis. Additionally, the study finds a higher abundance of Akkermansia muciniphila in the gut microbiomes of Ts-infected mice and shows that oral supplementation of A. muciniphila improves cardiac fibrosis via TLR2.
Review
Cell Biology
Niyati A. Borkar, Colin Kelly Combs, Venkatachalem Sathish
Summary: Evidence has shown that there are differential incidence, prevalence, and severity of asthma between males and females. Sex differences are recognized as a significant non-modifiable risk factor in asthma pathogenesis. Sex steroids play a critical role in human development and immune system regulation, with estrogen having conflicting reports on its role in inflammation and androgens being anti-inflammatory. Women have stronger and more responsive immune elements, but the higher prevalence of autoimmune and allergic diseases contradicts this observation, suggesting that hormonal differences between sexes might modulate the immune system regulation. This review discusses the potential relationship between the immune cell system and sex steroids in the context of asthma, contributing to a deeper understanding of asthma etiology.
Article
Biology
Rimma Laufer Britva, Aviad Keren, Marta Bertolini, Yehuda Ullmann, Ralf Paus, Amos Gilhar, Valerie Horsley
Summary: We investigated the role of innate lymphoid cells-type 1 (ILC1) in the development of alopecia areata (AA) and found a significant increase of ILC1 cells around the affected and unaffected hair follicles of AA patients. Further experiments showed that autologous circulating ILC1-like cells induced key characteristics of AA, including premature hair follicle regression, hair follicle cytotoxicity, and the collapse of the hair follicles' physiological immune privilege. Injection of activated ILC1-like cells into healthy human scalp skin caused rapid onset of AA lesions in mice. These findings challenge the notion that AA is solely a CD8+ T cell-driven autoimmune disease.
Article
Allergy
Anna V. Wiese, Jannis Duhn, Rabia Uelkue Korkmaz, Katharina M. Quell, Ibrahim Osman, Fanny Ender, Torsten Schroeder, Ian Lewkowich, Simon Hogan, Markus Huber-Lang, Franziska Gumprecht, Peter Koenig, Joerg Koehl, Yves Laumonnier
Summary: This study reveals the significant roles of C5aR1 in the trafficking and activation of inflammatory eosinophils, which have important implications for key aspects of allergic inflammation such as airway hyperresponsiveness, ILC2 cells, and T cell activation.
Article
Fisheries
Min Liu, Chen Chen, Qi-Cheng Wu, Jia-Le Chen, Li-Shang Dai, Sheng Hui Chu, Qiu-Ning Liu
Summary: The study identified PcChitinase 2 gene sequence from P. clarkii and investigated its spatial and temporal expression profiles. The gene was found to be expressed unequally in different tissues, with the highest expression in stomach, gut, and hepatopancreas. Knockdown of PcChitinase 2 gene led to suppression of most Toll-pathway-related immune genes, indicating its involvement in the innate immune responses of P. clarkii through modulation of the toll pathway.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Allergy
Pawel Majak, Katarzyna Molinska, Marta Latek, Blazej Rychlik, Marcin Wachulec, Andrzej Blauz, Aleksandra Budniok, Martyna Gruchala, Jakub Lach, Marta Sobalska-Kwapis, Monika Baranowska, Klaudyna Krolikowska, Dominik Strapagiel, Joanna Majak, Dorota Czech, Cezary Palczynski, Piotr Kuna
Summary: The study found that upper-airway dysbiosis related to frequent sweet consumption, frequent antibiotic use, and altered nasal immune function increases the risk of asthma in young children with CRS.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Virology
Rui Zhou, Li Liu, Yu Wang
Summary: Virus invasion triggers the host's innate immune response, leading to the production of cytokines and interferons to fight pathogens, and viral proteins are also recognized by pattern recognition receptors. Different TLRs play dual roles of protection and harm for specific viruses, and the relationship between TLRs and viral proteins is crucial for activating innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saima Kausar, Isma Gul, Ruochen Liu, Xiao-Xue Ke, Zhen Dong, Muhammad Nadeem Abbas, Hongjuan Cui
Summary: The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in physiological processes like immune responses, hematopoiesis, cell growth, and differentiation. In this study, researchers investigated the function of suppressors of cytokine signaling (SOCS) proteins in lepidopteran insects, particularly the Chinese oak silkworm. They identified the full-length sequence of a SOCS-2 protein called ApSOCS-2 and studied its role in the immune response through the JAK-STAT pathway. The results showed that ApSOCS-2 negatively regulates the transcription of antimicrobial peptide genes and plays a key role in the immune function of the insect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lucy H. Jackson-Jones, Dominik Ruckerl, Freya Svedberg, Sheelagh Duncan, Rick M. Maizels, Tara E. Sutherland, Stephen J. Jenkins, Henry J. McSorley, Cecile Benezech, Andrew S. MacDonald, Judith E. Allen
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Carlos M. Minutti, Lucy H. Jackson-Jones, Belen Garcia-Fojeda, Johanna A. Knipper, Tara E. Sutherland, Nicola Logan, Emma Rinqvist, Raquel Guillamat-Prats, David A. Ferenbach, Antonio Artigas, Cordula Stamme, Zissis C. Chroneos, Dietmar M. Zaiss, Cristina Casals, Judith E. Allen
Article
Microbiology
Dominik Ruckerl, Sharon M. Campbell, Sheelagh Duncan, Tara E. Sutherland, Stephen J. Jenkins, James P. Hewitson, Tom A. Barr, Lucy H. Jackson-Jones, Rick M. Maizels, Judith E. Allen
Article
Microbiology
Tara E. Sutherland, Dominik Ruckerl, Nicola Logan, Sheelagh Duncan, Thomas A. Wynn, Judith E. Allen
Article
Immunology
Freya R. Svedberg, Sheila L. Brown, Maria Z. Krauss, Laura Campbell, Catherine Sharpe, Maryam Clausen, Gareth J. Howell, Howard Clark, Jens Madsen, Christopher M. Evans, Tara E. Sutherland, Alasdair C. Ivens, David J. Thornton, Richard K. Grencis, Tracy Hussell, Danen M. Cunoosamy, Peter C. Cook, Andrew S. MacDonald
Editorial Material
Multidisciplinary Sciences
Judith E. Allen, Tara E. Sutherland
Article
Immunology
Alistair L. Chenery, Rafid Alhallaf, Zainab Agha, Jesuthas Ajendra, James E. Parkinson, Martha M. Cooper, Brian H. K. Chan, Ramon M. Eichenberger, Lindsay A. Dent, Avril A. B. Robertson, Andreas Kupz, David Brough, Alex Loukas, Tara E. Sutherland, Judith E. Allen, Paul R. Giacomin
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Jesuthas Ajendra, Alistair L. Chenery, James E. Parkinson, Brian H. K. Chan, Stella Pearson, Stefano A. P. Colombo, Louis Boon, Richard K. Grencis, Tara E. Sutherland, Judith E. Allen
MUCOSAL IMMUNOLOGY
(2020)
Article
Cell Biology
James E. Parkinson, Stella Pearson, Dominik Ruckerl, Judith E. Allen, Tara E. Sutherland
Summary: This study found that allergic airway inflammation and remodeling can occur in both BALB/c and C57BL/6 mice under allergen exposure, despite differences in immune response dynamics between the two strains. The study suggests that compositional changes in the extracellular matrix between genetic strains of mice may help understand the relationships between lung function, remodeling, and airway inflammation.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rueckerl
Summary: Peritoneal dialysis initially benefits patients with chronic kidney disease, but long-term use may lead to significant pathology, increasing the risk of infection and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Ben T. Bradley, Rebecca M. Carpenter, Jeffrey M. Sturek, Jennie Z. Ma, G. Brett Moreau, Jeffrey R. Donowitz, Gregory A. Buck, Myrna G. Serrano, Stacey L. Burgess, Mayuresh M. Abhyankar, Cameron Mura, Philip E. Bourne, Robert Preissner, Mary K. Young, Genevieve R. Lyons, Johanna J. Loomba, Sarah J. Ratcliffe, Melinda D. Poulter, Amy J. Mathers, Anthony Day, Barbara J. Mann, Judith E. Allen, William A. Petri
Summary: Research shows that elevated IL-13 levels are associated with severe COVID-19. In a mouse model, neutralizing IL-13 reduced disease severity and lung HA deposition. Administration of IL-13 induced HA in the lungs. Blocking the HA receptor CD44 prevented mortality, highlighting a potentially novel mechanism for IL-13-mediated HA synthesis in pulmonary pathology.
Article
Biology
Alistair L. Chenery, Silvia Rosini, James E. Parkinson, Jesuthas Ajendra, Jeremy A. Herrera, Craig Lawless, Brian H. K. Chan, P'ng Loke, Andrew S. MacDonald, Karl E. Kadler, Tara E. Sutherland, Judith E. Allen
Summary: IL-13 plays a critical role in limiting tissue injury and hemorrhaging in the lung during acute lung damage. Through proteomic and transcriptomic profiling analysis, IL-13-dependent changes in matrix remodeling and epithelial cell responses were identified. IL-13 is also required for the induction of epithelial-derived type 2 effector molecules and cellular stress responses in the context of acute lung damage.
LIFE SCIENCE ALLIANCE
(2021)
Editorial Material
Immunology
Tara E. Sutherland, Philippe E. Van den Steen
PARASITE IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Tara E. Sutherland, Douglas P. Dyer, Judith E. Allen
Summary: For decades, immunologists have focused on studying circulating immune cells, but recently there is a growing appreciation for the role of immune cells within the tissue microenvironment. However, the understanding of the extracellular matrix (ECM) and its interaction with the immune system remains limited. This review aims to explore the potential for biological discovery at the intersection of immunology and matrix biology.